Antimicrobial activity of the methanolic extract and compounds from the stem bark of Drypetes tessmanniana

Kuete, Victor; Dongfack, Marlise Diane Jiofack; Mbaveng, Armelle T.; Lallemand, Marie‐Christine; Van-Dufat, Hanh Trinh; Wansi, Jean-Duplex; Seguin, Elisabeth; Tillequin, François; Wandji, Jean

doi:10.1007/s11655-010-0527-8

Cited by 28 publications

(14 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3). MICs < 10 µg/mL were documented for many of them including lapachol (18), 2-acetylfuro-1,4-naphthoquinone (19), 2-hydroxy-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-1-carbaldehyde (20), newbouldiaquinone (21) [48]. Very interesting activities of plumbagin (22), diospyrone (23) and crassiflorone (24) were reported against M. tuberculosis, M. smegmatis and N. gonorrhoeae [49].…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Potential of Cameroonian Plants and Derived Products against Microbial Infections: A Review

2010

Self Cite

View full text Add to dashboard Cite

Section: Phenolic Compoundsmentioning

confidence: 99%

Potential of Cameroonian Plants and Derived Products against Microbial Infections: A Review

2010

Self Cite

View full text Add to dashboard Cite

“…To the best of our knowledge, the activity of this plant, compounds 1 and 8 on the microorganisms studied in the present work is being reported for the first time. Compounds with enough evidence of their antimicrobial microbial activities such lupeol [33], betulinic acid [34], ursolic acid [35], β -sitosterol, sitosterol-3- O-β-D -glucopyranoside [36,37], were not tested again in the present work. However, compounds such as lupeol exhibited moderate inhibitory effect against E. coli and Mycobacterium smegmatis [33].…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial activities of the methanol extract, fractions and compounds from Ficus polita Vahl. (Moraceae)

Kuete

Kamga

Sandjo

et al. 2011

BMC Complement Altern Med

Self Cite

View full text Add to dashboard Cite

BackgroundMany plants of the family Moraceae are used in the treatment of infectious diseases. Ficus polita Vahl., an edible plant belonging to this family is used traditionally in case of dyspepsia, infectious diseases, abdominal pains and diarrhea. The present work was designed to assess the antimicrobial activity of the methanol extract from the roots of F. polita (FPR), as well as that of its fractions (FPR1-5) and two of the eight isolated compounds, namely euphol-3-O-cinnamate (1) and (E)-3,5,4'-trihydroxy-stilbene-3,5-O-β-D-diglucopyranoside (8).MethodsThe liquid microdilution assay was used in the determination of the minimal inhibitory concentration (MIC) and the minimal microbicidal concentration (MMC), against seven bacterial and one fungal species.ResultsThe results of the MIC determination showed that the crude extract, fractions FPR1, FPR2 and compound 8 were able to prevent the growth of the eight tested microorganisms. Other samples showed selective activity. The lowest MIC value of 64 μg/ml for the crude extract was recorded on 50% of the studied microbial species. The corresponding value for fractions of 32 μg/ml was obtained on Salmonella typhi, Escherichia coli and Candida albicans ATCC strains. The MIC values recorded with compound 8 on the resistant Pseudomonas aeruginosa PA01 strain was equal to that of chloramphenicol used as reference antibiotic.ConclusionThe obtained results highlighted the interesting antimicrobial potency of F. polita as well as that of compound 8, and provided scientific basis for the traditional use of this taxon in the treatment of microbial infections.

show abstract

“…These bioactive compound groups are cited in many studies for theirs antifungal properties. Several phenolic compounds such as 3-geranyloxy-6-methyl-1,8-dihydroxyanthraquinone, vismiaquinone, bivismiaquinone and chlorogenic acid, isolated from plants, demonstrated significant antifungal activities (Kuete et al, 2007a;Jassim and Naji, 2003). Terpenoids like cymbopogonol and 3-oxo-(20S, 24S)epoxydammarane-19,25-diacetate isolated from the barks of Caesalpinia pulcherrina exhibited a prominent antifungal activity (Nasimul et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

In vitro evaluation of the antifungal activity of extracts of Baillonella toxisperma (Pierre), a Sapotaceae, on the growth of some human pathogenic yeasts

Essama¹,

Nyegue²,

Foe³

et al. 2015

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

An ethnopharmacological survey concerning medicinal properties of Baillonella toxisperma (Pierre) was carried out by interview with the indigenous population of Dimako village situated in the East region of Cameroon. The result showed that the plant is implicated in the treatment of many infections among which is fungal infections. To confirm the antifungal property of B. toxisperma (Pierre), the barks and leaves of the plant were collected and serial extractions in water, hydro-ethanol mixture (3:7), ethanol, methanol and ethyl acetate were performed in vitro. One part of the hydro-ethanol (3:7) extract was degreased by mixing in water-hexane mixture (1:1). The extracts were then tested in vitro against Candida albicans, Candida parasilopsis, Candida sp. responsible for superficial, deep or systemic mycosis and against Cryptococcus neoformans responsible for sub-acute meningitis in immunodeficient individuals. The susceptibility of yeasts to plant extracts was evaluated using the wells diffusion method and yeasts growth inhibition parameters were evaluated according to the proposed National Committee for Clinical Laboratory Standards (NCCLS) M27-A2 standard guidelines (2002). The minimal inhibitory concentrations (MIC) and minimal fungicidal concentrations (MFC) determined were between 0.93 and 30.0 mg/ml. The extracts were fungicidal on clinical yeasts tested with MFC/MIC ratio of 1 or 2. The hexane phase HT2 from the hydro-ethanol crude extract of the barks gave the best antifungal activity on C. neoformans, with a MIC of 0.93 mg/ml and a MFC of 1.87 mg/ml. This activity was similar to the one obtained with fluconazole. Phytochemical screening revealed the presence of polyphenols, phenols, tannins, flavonoids, steroids, alkaloids, saponins, phlobatannins, triterpenes, anthocyanins, cardiac glycosides, leucoanthocyanins and fats, which are bioactive substances. The results could explain scientific validation to the traditional medical uses of B. toxisperma (Pierre) to treat fungal infections.

show abstract

Antimicrobial activity of the methanolic extract and compounds from the stem bark of Drypetes tessmanniana

Abstract: The methanol extract from the stem bark of Drypetes. tessmanniana (Euphorbiaceae) as well as some of the isolated compounds might be potential sources of new antimicrobial drugs.

Cited by 28 publications

References 15 publications

Potential of Cameroonian Plants and Derived Products against Microbial Infections: A Review

Potential of Cameroonian Plants and Derived Products against Microbial Infections: A Review

Antimicrobial activities of the methanol extract, fractions and compounds from Ficus polita Vahl. (Moraceae)

In vitro evaluation of the antifungal activity of extracts of Baillonella toxisperma (Pierre), a Sapotaceae, on the growth of some human pathogenic yeasts

Contact Info

Product

Resources

About