Antimicrobial Activity of Topical Beta-Adrenergic Blocking Agents

Takahashi, Naohiko; Murota, Hiroyuki; Sutoh, Ichiro

doi:10.1159/000265272

Cited by 6 publications

(1 citation statement)

References 7 publications

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“…[45] triamiterene Streptococcus spp. [46] b-adrenergic blocker bacteria [42] Others acetyl salicylic acid active levomepromazine (Figure 4.4) [161]. Thioxanthenes differ from phenothiazines by having a carbon atom instead of nitrogen in the central ring, and exist in two geometric stereo-isomers, cis (Z) and trans (E) form, but only cis (Z) compounds have neuroleptic activity [162].…”

Section: Psychotherapeutics As Non-antibioticsmentioning

confidence: 99%

Non‐Antibiotics – An Alternative for Microbial Resistance: Scope and Hope

Chattopadhyay

Das

Patra

et al. 2008

New Strategies Combating Bacterial Infection

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The antimicrobial activity of non-chemotherapeutic compounds, such as methylene blue, phenothiazine, thioxanthene and related agents, has been known since the time of Paul Ehrlich . In this context the term nonantibiotics was introduced to include a variety of compounds used in the management of pathological conditions of noninfectious etiology. Despite the availability of hundreds of anti-infective drugs the emergence of antibiotic resistance and new infectious agents create the therapeutic challenge to the medical community. Hence, the search for newer agents to tackle the global problem is continuing. It has been noted that many of the phenothiazines,

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Section: Psychotherapeutics As Non-antibioticsmentioning

confidence: 99%

Non‐Antibiotics – An Alternative for Microbial Resistance: Scope and Hope

Chattopadhyay

Das

Patra

et al. 2008

New Strategies Combating Bacterial Infection

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The Use of Timolol for Wound Healing—A Review

Lyle,

Budhiraja,

Mehta

et al. 2024

Curr Derm Rep

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Purpose of Review In recent years, drug repurposing has gained traction as a method to accelerate the availability of effective treatments. This review focuses on timolol, originally a topical non-selective β-adrenergic antagonist used for increased intraocular pressure and glaucoma, and its emerging role in the wound healing landscape—a field that has been lacking in effective treatments for decades. Recent Findings Preclinical and clinical studies have highlighted timolol’s promise as a therapeutic option in wound healing. Its benefits are attributed to various mechanisms including improved re-epithelialization, modulation of inflammation, and wound maturation, in addition to its impacts microbial quorum sensing and virulence. However, existing research also points to the need for larger, more comprehensive clinical trials to determine optimal dosing, efficacy, and safety. Some such trials are presently underway. Summary Timolol presents a new avenue for wound healing therapies, overcoming limitations seen in current treatment options. This review outlines timolol’s historical context in wound care, elaborates on its pharmacological mechanisms, and assesses ongoing research to validate its therapeutic potential. Future studies are needed for more conclusive data on its efficacy and safety in wound management.

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Treatment of infectious disease: Beyond antibiotics

Nigam

Gupta

Sharma

2014

Microbiological Research

108

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Several antibiotics have been discovered following the discovery of penicillin. These antibiotics had been helpful in treatment of infectious diseases considered dread for centuries. The advent of multiple drug resistance in microbes has posed new challenge to researchers. The scientists are now evaluating alternatives for combating infectious diseases. This review focuses on major alternatives to antibiotics on which preliminary work had been carried out. These promising anti-microbial include: phages, bacteriocins, killing factors, antibacterial activities of non-antibiotic drugs and quorum quenching.

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Antimicrobial Activity of Topical Beta-Adrenergic Blocking Agents

Cited by 6 publications

References 7 publications

Non‐Antibiotics – An Alternative for Microbial Resistance: Scope and Hope

Non‐Antibiotics – An Alternative for Microbial Resistance: Scope and Hope

The Use of Timolol for Wound Healing—A Review

Treatment of infectious disease: Beyond antibiotics

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