Antimicrobial, Analgesic and Anti - Inflammatory Activity Reported on Tamarindus indica Linn Root Extract

Gupta, Sangeeta; Singh, Amit Kumar

doi:10.5530/pj.2017.3.70

Cited by 17 publications

(12 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results demonstrated the analgesic effect of the various fractions of Kleinia pendula, probably due to the central mechanisms. Medicinal plants used as analgesics such as Tamarindus indica and Curucuma zedoaria have been shown to increase the average latency period [39,40].…”

Section: Discussionmentioning

confidence: 99%

Analgesic, Anti-Inflammatory, Cytotoxic Activity Screening and UPLC-PDA-ESI-MS Metabolites Determination of Bioactive Fractions of Kleinia pendula

et al. 2020

View full text Add to dashboard Cite

Kleinia pendula (Forssk.) DC. is a prostrate or pendent dark green succulent herb found in the southwestern mountain regions of Saudi Arabia. The literature survey of the plant reveals a lack of phytochemical and pharmacological studies, although traditional uses have been noted. The objective of the present work was to assess the in vivo analgesic and anti-inflammatory activities, as well as, the in vitro cytotoxic potential of the fractions of Kleinia pendula, and correlate these activities to the plant metabolites. The methanolic extract of Kleinia pendula was subjected to fractionation with n-hexane, ethyl acetate, chloroform, n-butanol, and water. The fractions were screened for their analgesic and anti-inflammatory activities, as well as cytotoxic activity against breast, liver, and colon cancer cell lines. The n-hexane and chloroform fractions of Kleinia pendula showed significant cytotoxic activity against all three cancer cell lines tested. The ethyl acetate and chloroform fractions showed significant analgesic and anti-inflammatory activities. The metabolites in these three active fractions were determined using UPLC-PDA-ESI-MS. Thus, the analgesic and anti-inflammatory activities of the plant were attributed to its phenolic acids (caffeoylquinic acid derivatives, protocatechuic, and chlorogenic acids). While fatty acids and triterpenoids such as (tormentic acid) in the hexane fraction are responsible for the cytotoxic activity; thus, these fractions of Kleinia pendula may be a novel source for the development of new plant-based analgesic, anti-inflammatory, and anticancer drugs.

show abstract

Section: Discussionmentioning

confidence: 99%

Analgesic, Anti-Inflammatory, Cytotoxic Activity Screening and UPLC-PDA-ESI-MS Metabolites Determination of Bioactive Fractions of Kleinia pendula

et al. 2020

View full text Add to dashboard Cite

show abstract

“…D. palmatus fruits are more significant when compared with standard drug ciprofloxacin and streptomycin [2]. Due to presence of lipopolysaccharide layer in outer membrane of Gram-negative bacteria, its hydrophobicity acts as a strong permeability barrier against hydrophobic molecules [22]. Hydrophobic molecules can pass through cell wall of Gram-positive bacteria easier than the Gram-negative bacteria because the cell wall of the Gram-positive bacteria contained only peptidoglycan [23].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antimicrobial and Analgesic Activity of Diplocyclos Palmatus Fruits on Albino Mice

J¹,

Zeeyauddin²,

Pasham³

et al. 2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The present study is preplanned to assess the antimicrobial and analgesic activity of the collected plants of Diplocyclos palmatus from Moinabad, Ranga Reddy, Telangana. Methods: In this study, D. palmatus fruits were used to gain the ethanolic extract and were tested for the phytochemical screening, antimicrobial activity using agar diffusion method against Gram-negative bacteria (Escherichia coli) and Gram-positive (Bacillus) and to compare its effect with the marketed standard streptomycin, ciprofloxacin, and analgesic activity of plant was performed by tail clip, tails immersion, and radiant heat method. Results: The maximum zone of inhibition is shown in the Gram-negative bacteria (E. coli) compared to standard and control. The ethanolic extract of D. palmatus fruits was shown analgesic activity and it was found to be more remarkable when compared to the standard aspirin and control. From the results of three different methods at different dose of ethanolic extract (100 mg/kg, 200 mg/kg, 400 mg/kg followed by 0–5 min interval up to 30 min), tail immersion method at 200 mg/kg dose of the D. palmatus fruits extract was achieved good results i.e., in 10 min (11.4 ± 1.93) and 15 min (13.4 ± 1.63). In tail clip method, 400 mg/kg dose is in 10 min (11 ± 1.67) and 15 min (10 ± 0.707) achieved best output, while same thing radiant heat method 200 mg/kg dose of the D. palmatus fruits extract is in 10 min (11.3 ± 1.67) and 15 min (14 ± 1.82) achieved outstanding results. Conclusion: The analgesic and antimicrobial activity of ethanolic extract of D. palmatus fruits are more significant compared to the other part of D. palmatus. Hence, the study concludes that the plant is having both analgesic and antimicrobial activity, and therefore, it can be used for various therapeutic purposes and further analysis.

show abstract

“…Non-steroidal anti-inflammatory drugs (NSAIDs) act by inhibiting PGE2 synthesis. When NSAIDs are used for treating inflammation, pain and fever, then they may show several side effects [7][8]. Gastrointestinal ulceration, fluid retention, bronchospasm, and prolongation of bleeding time are common side effect of NSAIDs, while opioids develop addiction and dependency as a side effect during the clinical use of these drugs [2,9].…”

Section: Introductionmentioning

confidence: 99%

Analgesic, anti-inflammatory and anti-pyretic activities of methanolic extract of Cordyline fruticosa (L.) A. Chev. Leaves

Aziz¹,

Naher²,

Akter³

et al. 2019

jrp

View full text Add to dashboard Cite

Traditionally Cordyline fruticosa (L.) A. Chev. is being used for the treatment of various disorders, such as fever, headache, diarrhea, coughs, haemoptysis, small pox, madness, skin eruptions, joint pains, rheumatic bone pains, swelling pain and it is also used for abortion. The aim of our study wast o evaluate analgesic, anti-inflammatory and anti-pyretic activities of methanolic extract of C. Fruticosa leaves (MCFL). Analgesic effect of MCFL was investigated by using acetic acid induced writhing test, formalin-induced paw licking test, tail immersion test and hot plate test. The anti-inflammatory activity was assessed by using xylene induced ear edema test and cotton pellet induced granuloma test, whereas antipyretic effect was observed by utilizing Brewer's yeast-induced pyrexia test. In analgesic test, MCFL significantly (* p< 0.05, vs. control) reduced paw licking and abdominal writhing of mice in a dose dependent manner. MCFL at a dose of 800 mg/kg body weight, significantly increased pain threshold in tail immersion test and hot plate test. Significant anti-inflammatory effect was produced by MCFL by reducing xylene induced air edema and cotton pellet induced granuloma in a dose dependent manner. In anti-pyretic test, after 4th hour of respective treatment, MCFL at all doses exhibited anti-pyretic activity, when compared with control (* p < 0.05, vs. control). The results obtained demonstrate that C. fruticosa may provide a source of plant compounds with analgesic, anti-inflammatory and antipyretic activities.

show abstract

Antimicrobial, Analgesic and Anti - Inflammatory Activity Reported on Tamarindus indica Linn Root Extract

Abstract: ABSTRACT

Cited by 17 publications

References 33 publications

Analgesic, Anti-Inflammatory, Cytotoxic Activity Screening and UPLC-PDA-ESI-MS Metabolites Determination of Bioactive Fractions of Kleinia pendula

Analgesic, Anti-Inflammatory, Cytotoxic Activity Screening and UPLC-PDA-ESI-MS Metabolites Determination of Bioactive Fractions of Kleinia pendula

Evaluation of Antimicrobial and Analgesic Activity of Diplocyclos Palmatus Fruits on Albino Mice

Analgesic, anti-inflammatory and anti-pyretic activities of methanolic extract of Cordyline fruticosa (L.) A. Chev. Leaves

Contact Info

Product

Resources

About