Antimicrobial and Antifungal Activities of Three New Triterpenoid Glycosides

Abstract

The antimicrobial and antifungal activities of the MeOH extract of the flowers of Cephalaria transsylvanica and three triterpenic acid glycosides, transsylvanoside A–C from the flowers of the plant were assayed using an agar‐disc diffusion method. The results showed that both the MeOH extract and the glycosides possess antimicrobial and antifungal activities against Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Corynebacterium xerosis, Klebsiella pneumoniae, Candida utilis, Kluyveromyces fragilis, Aspergillus oryzae and Aspergillus flavus respectively.

Total Phenolic Content, Antioxidant Capacity and Antifungal Activity of Extracts of Carthamus tenuis and Cephalaria joppensis

“…But also if we compare our results with the findings of S. Kirmizigul and her colleages (ref. 26), that tested the antifungal activity of three pure triterpenoid glycosides isolated from C. transsylvanica, our results are higher. These compounds have saponin typical structure with carboxylic acid residue.…”

“…25 But the research of this group of the Cephalaria genus started more than two decades ago when they reported antimicrobial and antifungal activities of three new saponins (triterpenic glycosides), that were isolated from the methanolic extract of C. transsylvanica. 26 From C. paphlagonica they succeeded in isolation of two novel saponis, and they reported their antioxidant and antimicrobial activities. 27 Strong antibacterial activity was reported by this group for another two novel saponins (hederagenin derivatives), that were isolated from C. davisiana.…”

Pulvinulin A, Graminin C, and cis-Gregatin B – New Natural Furanones from Pulvinula sp. 11120, a Fungal Endophyte of Cupressus arizonica

“…This was carried out as described previously [14]. Briefly, a single colony of Escherichia coli ATCC 25922 was transferred to a 125 mL Erlenmeyer flask holding sterile LB medium (25 mL) and incubated overnight on a rotary shaker operating at 37°C and 250 rpm.…”

“…Antimicrobial activity of furanones 1 – 4 against Escherichia coli ATCC 25922 was evaluated using the agar diffusion method [14]. Diameters of the inhibition zones were measured after incubation for 24 h at 37°C.…”

Antimicrobially Active Hederagenin Glycosides from Cephalaria elmaliensis

“…In light of all of this knowledge, we decided to investigate the glycosidic compounds in Cephalaria elmaliensis (Dipsacaceae). Previous phytochemical investigations on different Cephalaria species have reported a number of triterpene saponins, iridoids, flavonoids, alkaloids, lignans, and their glycosidic compounds [4][5][6][7][8][9][10][11][12][13][14][15]. Triterpene saponins are the major examples of these types of substances [4][5][6][7][8][9][10][11].…”