Antimicrobial and antioxidant effects of phenolic constituents fromKlainedoxa gabonensis

Wansi, Jean Duplex; Chiozem, David Dako; Tcho, Alain Tadjong; Toze, Flavien A. A.; Devkota, Krishna Prasad; Ndjakou, Bruno Lenta; Wandji, Jean; Sewald, Norbert

doi:10.3109/13880200903486644

Cited by 21 publications

(15 citation statements)

References 16 publications

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“…Given the medical importance of the tested bacteria, the present results offer promise in terms of developing new antibacterials. The antibacterial activity of oleanolic acid, ellagic acid, and 2β-hydroxyoleanolic acid coincide with previous findings (42,43). All of the compounds that were found to be active in the present study are members of the triterpenoid, flavonoid, and phenolic acid groups.…”

Section: Antibacterial Activitysupporting

confidence: 92%

“…This is very promising in terms of discovering antioxidants from plants. The antioxidant activity of compounds 2 and 4 agreed with previously reported findings (42,49). However, the present study is the first to document the antioxidant activity of the MeOH, EtOAc and n-BuOH extracts of L. leptocarpa as well as that of compounds 3, 6, and 8.…”

Section: Antioxidant Activitysupporting

confidence: 92%

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Complex secondary metabolites from Ludwigia leptocarpa with potent antibacterial and antioxidant activities

Mabou

Tamokou

Ngnokam

et al. 2016

DD&T

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Section: Antibacterial Activitysupporting

confidence: 92%

Section: Antioxidant Activitysupporting

confidence: 92%

Complex secondary metabolites from Ludwigia leptocarpa with potent antibacterial and antioxidant activities

Mabou

Tamokou

Ngnokam

et al. 2016

DD&T

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“…They show a large variety of biological activities including antioxidant, antimicrobial and anticancer activity (Faried et al, 2007;Wansi et al, 2010;Hagiwara et al, 2010). EA and GA can exist in plant material in free form but the main sources of these compounds are hydrolyzable tannins (ellagitannins and gallotannins), which upon hydrolysis release a sugar and a respective acid moiety (Haslam, 2007;Serrano et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Quantitative Determination of Ellagic Acid and Gallic Acid in Geum Rivale L. and G. Urbanum L.

Owczarek¹,

Olszewska²,

Gudej³

2015

Acta Biologica Cracoviensia S. Botanica

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Hydrolyzable tannins and products of their hydrolysis, ellagic acid (EA) and gallic acid (GA), are important constituents of many medicinal plants and exhibit various biological activities. Geum rivale and G. urbanum are traditional herbal remedies rich in tannin compounds. The aim of the study was to quantitate free and total EA and GA in aerial and underground parts of G. rivale and G. urbanum. After optimization of extraction, both compounds were quantitated by reversed phase HPLC (RP-HPLC). EA was more abundant than GA in the investigated material, and underground parts of G. rivale were the richest source of total EA and GA.K Ke ey y w wo or rd ds s: : Geum rivale, Geum urbanum, phenolic acid, Rosaceae.

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“…There are many phenolic compounds with similar MICs. [26][27][28][29][30][31] However, the introduction of a methyl group in the 2-position of the phenol ring resulted in the very active compound 4b that had the highest antibacterial activity, which equivalent to that of ciprofloxacin, with MIC and MBC values of 11 and 22 µM respectively ( Table 1). The zone of inhibition on agar plates for 4a, b and ciprofloxacin against M. catarrhalis type strain were found to be 13, 15 and 20 mm, respectively.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of Nitrobenzyl-oxy-phenol Derivatives

Mohamed

Maki

Shah

et al. 2016

Biological & Pharmaceutical Bulletin

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Two hydroquinone derivatives were prepared and their antimicrobial activity evaluated. Their minimum inhibitory concentrations (MICs) were determined using a broth dilution method. Gentamycin and ciprofloxacin were used as reference antibiotics. The antimicrobial activity of 4-(benzyloxy)phenol (monobenzone) was also evaluated based on its structural similarity to the new compounds; activity was comparable to that of 3,5-dimethyl-4-((4-nitrobenzyl)oxy)phenol (4a). 2,3,5-Trimethyl-4-((4-nitrobenzyl)oxy)phenol (4b) exhibited the best antibacterial activity against both clinical isolates and type strain of Moraxella catarrhalis (M. catarrhalis), with a MIC value of 11 µM, comparable to ciprofloxacin 9 µM.

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Antimicrobial and antioxidant effects of phenolic constituents fromKlainedoxa gabonensis

Cited by 21 publications

References 16 publications

Complex secondary metabolites from <i>Ludwigia leptocarpa</i> with potent antibacterial and antioxidant activities

Complex secondary metabolites from <i>Ludwigia leptocarpa</i> with potent antibacterial and antioxidant activities

Quantitative Determination of Ellagic Acid and Gallic Acid in Geum Rivale L. and G. Urbanum L.

Synthesis and Antimicrobial Activity of Nitrobenzyl-oxy-phenol Derivatives

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