Complex secondary metabolites from &lt;i&gt;Ludwigia leptocarpa&lt;/i&gt; with potent antibacterial and antioxidant activities

Mabou, Florence Déclaire; Tamokou, Jean-De-Dieu; Ngnokam, David; Voutquenne-Nazabadioko, Laurence; Jules-Roger, Kuiate; Bag, Prasanta K.

doi:10.5582/ddt.2016.01040

Cited by 18 publications

(13 citation statements)

References 38 publications

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“…These flavonoids have been commonly found in edible plants and have been identified in at least 20 plant families worldwide . With regards to their antibacterial activity, (2 R ,3 S ,2′′ S ) 3′′′,4′,4′′′,5,5″,7,7″-heptahydroxy-3,8″-biflavanone and luteolin-8- C -glucoside were found to have high activity against S. aureus . This same study found that both of these flavonoids were highly active against Shigella flexneri and moderately active against V. cholerae .…”

Section: Plant-derived Compounds With Antibacterial Propertiesmentioning

confidence: 64%

Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

et al. 2020

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The crisis of antibiotic resistance necessitates creative and innovative approaches, from chemical identification and analysis to the assessment of bioactivity. Plant natural products (NPs) represent a promising source of antibacterial lead compounds that could help fill the drug discovery pipeline in response to the growing antibiotic resistance crisis. The major strength of plant NPs lies in their rich and unique chemodiversity, their worldwide distribution and ease of access, their various antibacterial modes of action, and the proven clinical effectiveness of plant extracts from which they are isolated. While many studies have tried to summarize NPs with antibacterial activities, a comprehensive review with rigorous selection criteria has never been performed. In this work, the literature from 2012 to 2019 was systematically reviewed to highlight plant-derived compounds with antibacterial activity by focusing on their growth inhibitory activity. A total of 459 compounds are included in this Review, of which 50.8% are phenolic derivatives, 26.6% are terpenoids, 5.7% are alkaloids, and 17% are classified as other metabolites. A selection of 183 compounds is further discussed regarding their antibacterial activity, biosynthesis, structure−activity relationship, mechanism of action, and potential as antibiotics. Emerging trends in the field of antibacterial drug discovery from plants are also discussed. This Review brings to the forefront key findings on the antibacterial potential of plant NPs for consideration in future antibiotic discovery and development efforts.

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Section: Plant-derived Compounds With Antibacterial Propertiesmentioning

confidence: 64%

Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

et al. 2020

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“…Some species of the Ludwigia genus show promising sources of anticancer phytochemicals [ 30 ] and antioxidants [ 30 , 31 , 32 ], with antibacterial [ 31 , 32 , 33 ] and antifungal activity [ 34 ]. However, no studies have been reported showing the insecticidal potential of this genus.…”

Section: Introductionmentioning

confidence: 99%

“…and L. leptocarpa (Nutt.) Hara, they were found to have saponins [ 31 ], and L. adscendens (L.) H. Hara was found to contain tannins, alkaloids, flavonoids, terpenes, triterpenoids and phenols.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Bioactivity of Ludwigia spp. in the Control of Plutella xylostella (Lepidoptera: Plutellidae)

Ferreira

Souza

Domingues

et al. 2020

Insects

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We tested the bioactivity of aqueous extracts of Ludwigia spp. (Myrtales: Onagraceae) on the biological cycle of Plutella xylostella. We assessed the duration of and viability during the larval, pupal and adult phases, as well as the influence of the extracts on the fecundity and hatching of P. xylostella eggs. Subsequently, we phytochemically screened the extracts. The extracts of L. tomentosa and L. longifolia reduced the pupal weight instead of prolonging the larval stage of P. xylostella. The L. tomentosa effect caused higher larval mortality and reduced the fecundity and hatching of P. xylostella eggs, and L. sericea reduced the egg survival. The phenolic compounds—flavonoids, condensed tannins and alkaloids—were more abundant in L. nervosa, L. tomentosa, L. sericea and L. longifolia. The L. tomentosa, L. longifolia and L. sericea extracts were bioactive, and these species showed the best results regarding their ability to control P. xylostella populations, because these plants produce substances able to inhibit food consumption and interfere with the morphological and physiological transformations of the offspring and the oviposition of adults.

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“…As resistance to firstto fourth-generation antibiotics gains force, the development of new antimicrobial agents must be a priority if the problem is to be contained [7]. The plants are a large and unexplored reservoir of secondary metabolites, such as tannins, terpenoids, alkaloids, and flavonoids which have shown antimicrobial properties [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Therapeutic Potentials of the Capsicum annuum Extract against Infected Wound in a Rat Model with Its Mechanisms of Antibacterial Action

Ekom

Tamokou

Kuete

2021

BioMed Research International

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The wound healing process is essential to reform the damaged tissue and prevent its invasion by pathogens. The present study aims at evaluating the antibacterial and therapeutic properties of the Capsicum annuum L. (Solanaceae) extract against infected wound in a rat model with its mechanisms of antibacterial action. The fruit extract was prepared by maceration in methanol. The broth microdilution method was used to investigate the antibacterial activity of the methanol extract of C. annuum fruits. The therapeutic effect of the extract gel was performed on an excision wound infected with Staphylococcus aureus using a rat model. The total phenol, flavonoid, and tannin contents as well as the antibacterial mechanisms of action of the extract were determined using spectrophotometric methods. The C. annuum fruit extract showed antibacterial properties which can be linked to its total phenolic, flavonoid, and tannin contents. The antibacterial activity is due to the inhibition of the biofilm formation, ATPases/H+ proton pump, and dehydrogenase activity as well as the alteration of the bacterial cell membrane through the leakage of nucleic acids, reducing sugars and proteins. The extract gel showed a significant ( p < 0.05 ) increase in the percentage of wound closure and eradicated S. aureus at the infection site. The extract gel was nonirritating to the skin and slightly irritating to the eyes and should be used with caution. Overall, the findings of the present study support the traditional use of the studied plant in the treatment of wounds and infectious diseases associated with the tested bacteria.

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Complex secondary metabolites from <i>Ludwigia leptocarpa</i> with potent antibacterial and antioxidant activities

Cited by 18 publications

References 38 publications

Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

Phytochemical Screening and Bioactivity of Ludwigia spp. in the Control of Plutella xylostella (Lepidoptera: Plutellidae)

Antibacterial and Therapeutic Potentials of the Capsicum annuum Extract against Infected Wound in a Rat Model with Its Mechanisms of Antibacterial Action

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