Antimicrobial and antiproliferative activities of stingless bee Melipona scutellaris geopropolis

Cunha, Marcos Guilherme da; Franchin, Marcelo; Galvão, Lívia Câmara de Carvalho; Ruiz, Ana Lúcia Tasca Góis; Carvalho, João Ernesto de; Ikegaki, Masaharu; Alencar, Severino Matias de; Koo, Hyun; Rosalen, Pedro Luiz

doi:10.1186/1472-6882-13-23

Cited by 100 publications

(88 citation statements)

References 28 publications

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“…Stingless bee is a large group of eusocial insects that pollinate plant in tropical regions [12,13]. Stingless bee propolis in Thailand and India is more popular for treatments of diseases such as acne, diabetes and inflammatory conditions [13,14].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical analysis and antioxidant activities of Trigona Apicalis propolis extract

Rosli¹,

Roslan²,

Omar³

et al. 2016

AIP Conference Proceedings

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Abstract. Propolis is a resinous substance found in beehives. It provides beneficial effects on human health and has been used to treat many diseases since ancient times. The objectives of this study were to analyze the phytochemical profile of propolis derived from local T. apicalis species and its antioxidant activities. The ethanolic extract of propolis was subjected to HPLC analysis to analyze its phytochemical profile. The propolis extract was later tested for antioxidant capacities by using DPPH radical scavenging assay. TPC and TFC were performed to determine the correlation with its antioxidant activities. TEAC for each serial dilution sample was 2621.15 (4.76 mg/mL), 2050.85 (2.38 mg/mL), 1883.27 (1.19 mg/mL), 1562.67 (0.59 mg/mL), 1327.82 (0.29 mg/mL), 1164.49 (0.15 mg/mL), 983.27 (0.07 mg/mL), and 944.79 (0.04 mg/mL). The results demonstrated that the antioxidant activities of propolis extract were dose dependent. The IC50 of propolis for DPPH assay was 4.27 mg/ml. Correlation values of TPC and TFC against DPPH indicate that the antioxidant activities of propolis extract used in this study could be mainly influenced by the phenolic and flavonoid contents. These findings highlighted the importance of quality analysis in order to ensure the consistency of biological effects or therapy of a natural product, such as propolis.

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Section: Introductionmentioning

confidence: 99%

Phytochemical analysis and antioxidant activities of Trigona Apicalis propolis extract

Rosli¹,

Roslan²,

Omar³

et al. 2016

AIP Conference Proceedings

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show abstract

“…This type of propolis has been scarcely described in the literature, and little is known about its chemical composition and biological activity (da Cunha et al 2013). The chemical composition of geopropolis depends on the local flora, the geographic and climatic characteristics of the area where the sample is collected (Pino et al 2006).…”

Section: Resultsmentioning

confidence: 99%

Analysis of volatile components from Melipona beecheii geopropolis from Southeast Mexico by headspace solid-phase microextraction

Torres-González

López-Rivera

Duarte-Lisci

et al. 2015

Natural Product Research

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A head space solid-phase microextraction method combined with gas chromatography-mass spectrometry was developed and optimised to extract and analyse volatile compounds of Melipona beecheii geopropolis. Seventy-three constituents were identified using this technique in the sample of geopropolis collected. The main compounds detected include β-fenchene (14.53-15.45%), styrene (8.72-9.98%), benzaldehyde (7.44-7.82%) and the most relevant volatile components presents at high level in the geopropolis were terpenoids (58.17%).

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“…Assim como já demonstrado pela própolis das abelhas do gênero Apis, alguns estudos vêm comprovando a capacidade da geoprópolis produzida pelos meliponídeos em inibir o crescimento de bactérias patogênicas que adquirem com bastante frequência resistência aos antibióticos sintéticos e apresentam alto grau de patogenicidade para seres humanos e animais (Cunha et al 2013, Fianco et al 2013, Campêlo et al 2015, Lima 2015.…”

Section: Atividade Antibacterianaunclassified

Quantificação de fenóis, flavonoides totais e atividades farmacológicas de geoprópolis de Plebeia aff. Flavocincta do Rio Grande do Norte

Silva

Costa

Coelho³

et al. 2016

Pesq. Vet. Bras.

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Resumo: Esse estudo objetivou avaliar a composição química e potencial terapêutico do extrato hidroalcóolico de geoprópolis produzidas por abelhas Plebeia aff. flavocincta no semiárido do Rio Grande do Norte. Oito amostras (A-H) foram submetidas a quantificação dos teores de fenóis e flavonoides totais e avaliação da atividade antioxidante através do método DPPH (2,2-difenil-1-picril-hidrazilo). Além disso, foram investigadas as atividades antibacteriana, através do método de difusão em ágar, e a cicatrizante, através da indução de feridas cirúrgicas experimentais em Rattus norvegicus Berkenhout, 1769, linhagem Wistar, tratados com creme à base de geoprópolis. Duas amostras (F e G) se destacaram por apresentar altos valores de fenóis e flavonoides totais. A capacidade antioxidante acima de 90% foi observada em cinco amostras. Os extratos foram considerados eficazes no que se refere a atividade antibacteriana, pois das oito amostras, cinco promoveram a formação de halos de inibição ≥9mm para todas as cepas testadas. Duas amostras (D e G) se destacaram em relação as demais por apresentar excelentes resultados, uma vez que, promoveram a formação de halos de inibição para as bactérias Staphylococcus epidermidis e Escherichia coli, superiores estatisticamente aos valores dos antibióticos controles, quando na concentração de 100%. As amostras A e G promoveram, respectivamente, a formação de halos de inibição, que não diferiram significativamente dos halos produzidos pelos antibióticos controles em todas as concentrações testadas para E. coli e Staphylococcus aureus. A análise do processo de cicatrização sob os pontos de vista clínico, macroscópico e histológico permitiu concluir, que o uso do creme à base de geoprópolis apresentou influência positiva na cicatrização de feridas cutâneas experimentais, por promover reação inflamatória menos intensa e fechamento mais rápido das feridas em relação ao grupo controle.

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Antimicrobial and antiproliferative activities of stingless bee Melipona scutellaris geopropolis

Cited by 100 publications

References 28 publications

Phytochemical analysis and antioxidant activities of Trigona Apicalis propolis extract

Phytochemical analysis and antioxidant activities of Trigona Apicalis propolis extract

Analysis of volatile components from Melipona beecheii geopropolis from Southeast Mexico by headspace solid-phase microextraction

Quantificação de fenóis, flavonoides totais e atividades farmacológicas de geoprópolis de Plebeia aff. Flavocincta do Rio Grande do Norte

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