Antimicrobial and Cytocompatible Bovine Hydroxyapatite-Alumina-Zeolite Composite Coatings Synthesized by Pulsed Laser Deposition from Low-Cost Sustainable Natural Resources

Abstract

Bovine hydroxyapatite (BHA) and BHA blended with clinoptilolite (CLIN) and alumina (Al 2 O 3 ) coatings were synthesized using pulsed laser deposition (PLD) with a KrF* excimer laser source (λ = 248 nm, τ FWHM ≤ 25 ns). Physical− chemical characteristics and the potential use of coatings for preventing bacteria adhesion and biofilm formation were investigated. Optimized PLD conditions were selected for coatings with rough morphologies, suitable for good cell adhesion and implant anchorage and good replication of the source target composition. The crystallinity of composite coatings was progressively decreasing with the augment of the Al 2 O 3 and CLIN contents, which in turn can facilitate an efficacious release of active components. Al 2 O 3 -and CLIN-containing coatings exhibited high cytocompatibility and specific antibiofilm profiles, preventing the initiation and maturation of bacterial biofilms. Optimum biological activity profiles associated with the use of sustainable and/or inexpensive materials are, in our opinion, of key importance for the future development of performant implant coatings, which should be perfectly compatible with the surrounding tissue while preventing postsurgical endogenous or nosocomial infections.

3D printed gelatin/decellularized bone composite scaffolds for bone tissue engineering: Fabrication, characterization and cytocompatibility study

“…Besides the GEL cytocompatibility, cell viability was enhanced by reinforcement with dbPTs due to their inorganic hydroxyapatite crystals and collagen fibers contents. The cytocompatibility of these ingredients has been individually reported in numerous previous studies [ [88] , [89] , [90] ].…”

Regulating the Superficial Vacancies and OH− Orientations on Polarized Hydroxyapatite Electrocatalysts

“…[ 1 ] A great deal of effort has been put into developing customized HAp‐based materials with reinforced properties to fulfill the requirements of specific applications. [ 2,3 ] Within this context, the ability to control the electrical properties of HAp is attracting increased attention, as those properties not only have demonstrated to play a crucial role in tissue engineering [ 4 ] and smart bioengineering [ 5 ] but also to open the way for other uses, such as electronics [ 6 ] and green catalysis. [ 7,8 ]…”

Composite Drug Delivery System Based on Amorphous Calcium Phosphate–Chitosan: An Efficient Antimicrobial Platform for Extended Release of Tetracycline

“…The large-scale development of implants in different medical fields is, unfortunately, restricted by a growing number of related infections [1]. The associated severe complications often lead to prolonged excruciating pain, increased costs, and eventually implant loss and mandatory revision [2,3].…”