Antimicrobial and Cytotoxic Activities of Secondary Metabolites from the Soft Coral Derived Fungus Aspergillus sp.

Said, Gulab; Hou, Xuemei; Liu, Xin; Chao, Rong; Jiang, Yao-Yao; Zheng, Jianyi; Shao, Chang‐Lun

doi:10.1007/s10600-019-02732-5

Cited by 13 publications

(7 citation statements)

References 14 publications

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“…Moreover, in the presence of sodium chloride salt in the medium the production of asterric acid was very low (Boruta & Bizukojc, 2016;Said et al, 2019;Said & Ahmad, 2022). The yield of asterric acid decreases with an increase in salt concentration (figure 4(b)).…”

Section: Discussionmentioning

confidence: 96%

Optimal conditions for the high yield of bioactive asterric acid from marine derived Fungus Aspergillus sp.

Said

Wahab

Umair

2022

Nat. App. Sci. Int. J.

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Marine-derived microorganisms are vital sources of bioactive secondary metabolites. Secondary metabolites of coral-derived fungi have several essential bioactivities. Asterric acid 1 is a broad-spectrum bioactive secondary metabolite of several fungal genera, especially Aspergillus and Penicillium. It has a wide range of interesting bioactivities such as antifungal, antimicrobial, cytotoxic, fungicidal, pesticidal, nematicidal, seed germination inhibition, anti-HIV activity, as a first non-peptide for endothelin binding inhibition, anti-plasmodial activity against the erythrocyte stages of chloroquine-resistant Plasmodium falciparum, having vascular endothelial growth factor inhibitory activity and as medicine for the initial stage of an endothelin receptor agonist. In this study, the yield of asterric acid was improved to a multi-gram quantity from the soft coral-derived fungus Aspergillus sp. through media optimization. The pure spoors of Aspergillus sp. were fermented at room temperature in the absence of sodium chloride salt. The yield of asterric acid was 650 mg/L at optimal conditions. The optimal conditions for the high yield of asterric acid were found as rice medium, room temperature, 56 days incubation and absence of sodium chloride salt.

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Section: Discussionmentioning

confidence: 96%

Optimal conditions for the high yield of bioactive asterric acid from marine derived Fungus Aspergillus sp.

Said

Wahab

Umair

2022

Nat. App. Sci. Int. J.

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“…derived from soft coral were active against V. anguillarum , Aeromonas salmonicida , and P. aeruginosa with MICs of 15.06, 15.15, 7.53 μM and 30.12, 30.3, and 3.78 μM, respectively. Moreover, 324 also revealed moderate activity against Jurkat, A549, and HeLa cells with IC 50 values of 10.69, 10.69, and 3.56 μM, respectively [ 148 ]. Two known benzaldehyde compounds, isodihydroauroglaucin ( 325 ) and flavoglaucin ( 326 ), exhibited evident antiviral activity against HSV-1 with EC 50 values of 4.73 and 6.95 μM, respectively.…”

Section: Aromaticsmentioning

confidence: 99%

Secondary Metabolites from Coral-Associated Fungi: Source, Chemistry and Bioactivities

Chen

Pang

et al. 2022

JoF

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Our study of the secondary metabolites of coral-associated fungi produced a valuable and extra-large chemical database. Many of them exhibit strong biological activity and can be used for promising drug lead compounds. Serving as an epitome of the most promising compounds, which take the ultra-new skeletons and/or remarkable bioactivities, this review presents an overview of new compounds and bioactive compounds isolated from coral-associated fungi, covering the literature from 2010 to 2021. Its scope included 423 metabolites, focusing on the bioactivity and structure diversity of these compounds. According to structure, these compounds can be roughly classified as terpenes, alkaloids, peptides, aromatics, lactones, steroids, and other compounds. Some of them described in this review possess a wide range of bioactivities, such as anticancer, antimicrobial, antifouling, and other activities. This review aims to provide some significant chemical and/or biological enlightenment for the study of marine natural products and marine drug development in the future.

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“…SYSU-SK-7 by She group displaying potent anti-microbial activities against P. aeruginosa with MIC values of 3.27, 1.67 and 2.10 μg/mL, respectively [ 55 ]. Compounds 51 and 52 , connecting two phenol groups by carbonyl group and spiro ring, respectively, was isolated by Shao group from soft coral-derived fungus Aspergillus sp., and demonstrated good anti-microbial activities against P. aeruginosa with MIC values of 7.53 and 3.78 μM, respectively [ 56 ].…”

Section: Emerging Mnps As Promising Antibiotics For Inhibiting ...mentioning

confidence: 99%

Discovery of Marine Natural Products as Promising Antibiotics against Pseudomonas aeruginosa

Maimaitiming

Zhou

et al. 2022

Marine Drugs

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Pseudomonas aeruginosa, one of the most intractable Gram-negative bacteria, has become a public health threat due to its outer polysaccharide layer, efflux transporter system, and high level of biofilm formation, all of which contribute to multi-drug resistance. Even though it is a pathogen of the highest concern, the status of the antibiotic development pipeline is unsatisfactory. In this review, we summarize marine natural products (MNPs) isolated from marine plants, animals, and microorganisms which possess unique structures and promising antibiotic activities against P. aeruginosa. In the last decade, nearly 80 such MNPs, ranging from polyketides to alkaloids, peptides, and terpenoids, have been discovered. Representative compounds exhibited impressive in vitro anti-P. aeruginosa activities with MIC values in the single-digit nanomolar range and in vivo efficacy in infectious mouse models. For some of the compounds, the preliminary structure-activity-relationship (SAR) and anti-bacterial mechanisms of selected compounds were introduced. Compounds that can disrupt biofilm formation or membrane integrity displayed potent inhibition of multi-resistant clinical P. aeruginosa isolates and could be considered as lead compounds for future development. Challenges on how to translate hits into useful candidates for clinical development are also proposed and discussed.

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Antimicrobial and Cytotoxic Activities of Secondary Metabolites from the Soft Coral Derived Fungus Aspergillus sp.

Cited by 13 publications

References 14 publications

Optimal conditions for the high yield of bioactive asterric acid from marine derived Fungus Aspergillus sp.

Optimal conditions for the high yield of bioactive asterric acid from marine derived Fungus Aspergillus sp.

Secondary Metabolites from Coral-Associated Fungi: Source, Chemistry and Bioactivities

Discovery of Marine Natural Products as Promising Antibiotics against Pseudomonas aeruginosa

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