Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Essential Oils of Selected Aromatic Plants from Tajikistan

Abstract

Antimicrobial, antioxidant, and anti-inflammatory activities of the essential oils of 18 plant species from Tajikistan (Central Asia) were investigated. The essential oil of Origanum tyttanthum showed a strong antibacterial activity with both minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 312.5 µg/mL for E. coli, 625 µg/mL (MIC) and 1250 µg/mL (MBC) for MRSA (methicillin-resistant Staphylococcus aureus), respectively. The essential oil of Galagania fragrantissima was highly active against MRSA at concentrations as low as 39.1 µg/mL and 78.2 µg/mL for MIC and MBC, respectively. Origanum tyttanthum essential oil showed the highest antioxidant activity with IC50 values of 0.12 mg/mL for ABTS (2,2′-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid)) and 0.28 mg/mL for DPPH (2,2-diphenyl-1-picrylhydrazyl). Galagania fragrantissima and Origanum tyttanthum essential oils showed the highest anti-inflammatory activity; IC50 values of 5-lipoxygenase (5-LOX) inhibition were 7.34 and 14.78 µg/mL, respectively. In conclusion, essential oils of Origanum tyttanthum and Galagania fragrantissima exhibit substantial antimicrobial, antioxidant, and anti-inflammatory activities. They are interesting candidates in phytotherapy.

Anti-Inflammatory, Antioxidant, Antibiotic, and Cytotoxic Activities of Tanacetum vulgare L. Essential Oil and Its Constituents

“…The essential oil of T. vulgare demonstrated antioxidant activity by significantly inhibiting the oxidation of DCFH induced by tert-butylhydroperoxide with an IC 50 of 51 µg·mL −1 ( Table 2 ). Using in vitro methods including DPPH, ABTS, and FRAP assays, Shaparov et al [ 32 ] also reported a moderate level of antioxidant activity of T. vulgare essential oil. Unfortunately, the chemical composition of the oil was not analyzed and the compounds responsible for the activity were not identified.…”

“…Antibacterial activity of T. vulgare from Roumania [ 9 ] and Slovakia [ 38 ] were also reported against gram-positive bacterial strains using the disc diffusion method. Moreover, T. vulgare essential oil from Tajikistan was found to be weakly effective against E. coli and MRSA [ 32 ]. In our study, we used a new antibiotic assay developed to test hydrophobic compounds as described in the Material and Methods section [ 25 ].…”

Antibacterial, Anti‐Inflammatory, Antioxidant, and Antiproliferative Properties of Essential Oils from Hairy and Normal Roots of Leonurus sibiricus L. and Their Chemical Composition

“…The essential oils of many plants are known to have antimicrobial activity [ 4 , 36 , 37 ], which could act as a chemical defence against various pathogens. The present study examines the antimicrobial activities against all tested strains, which may be attributed to the presence of sesquiterpenes such as (E) - β -caryophyllene or germacrene D in the tested oils.…”

Kazakh Ziziphora Species as Sources of Bioactive Substances

“…Moreover, antioxidant properties and anti-inflammatory effect was evaluated using different methods. 5-LOX was inhibited by Z. clinopodioides esstential oil (could be due to the presence of compounds structurally related to fatty acids serving as substrate of LOX) [420].…”