Antimicrobial, Antiviral and Cytotoxic Activity of New Zealand Lichens

Perry, Nigel B.; Benn, M. H.; Brennan, Nerida J.; Burgess, Elaine J.; Ellis, Gill; Galloway, D. J.; Lorimer, Stephen D.; Tangney, Raymond S.

doi:10.1006/lich.1999.0241

Cited by 96 publications

(95 citation statements)

References 24 publications

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“…After that, disks were placed onto agar Petri plates and incubated. The inhibitory activity was indicated by clear zones around the disks, and inhibition zone diameters were measured in millimeters after incubation for 24 h at 37 C (Perry et al, 1999). All tests were performed in triplicate.…”

Section: Antimicrobial Activity Assaysmentioning

confidence: 99%

HPLC Analysis of Usnic Acid in SomeRamalina. Species from Anatolia and Investigation of their Antimicrobial Activities

Cansaran

Atakol

Halıcı

et al. 2007

Pharmaceutical Biology

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Five species of lichens, Ramalina fastigiata (Pers.) Ach., Ramalina capitata, (Ach.) Nyl., Ramaliana polymorpha (Lilj.) Ach., Ramalina pollinaria (Westr.) Ach., and Ramalina fraxinea (L.) Ach., belonging to family Ramalinacae were collected from middle Anatolia, Ankara, Antalya, Karabü k, and Kayseri in Turkey. Their usnic acid amounts were determined by HPLC in acetone extracts. Furthermore, antimicrobial activities of these extracts were determined against Escherichia coli (ATCC 35218), Enterococcus faecalis (RSKK 508), Proteus mirabilis (Pasteur Ens. 235), Staphylococcus aureus, Bacillus subtilis, and Bacillus megaterium. It was observed that, as the usnic acid amount increased, the antimicrobial activities were increased. Results pointed out that usnic acid contents of Ramalina species varied between 0.13% and 3.23% dry weight.

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Section: Antimicrobial Activity Assaysmentioning

confidence: 99%

HPLC Analysis of Usnic Acid in SomeRamalina. Species from Anatolia and Investigation of their Antimicrobial Activities

Cansaran

Atakol

Halıcı

et al. 2007

Pharmaceutical Biology

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“…also inhibited the growth of malignant cell lines (Ogmundsdottir et al, 1998). Crude extracts from various lichen species were also screened for their cytotoxic activities and some of them were found to be cytotoxic in different cancer cell lines by two different groups (Perry et al, 1999;Bezivin et al, 2003). Recently, antiproliferative effects of several lichen compounds in human platelets were shown due to their inhibitory activities on 12(S)-HETE which has a role in carcinogenesis and metastasation (Bucar et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Determination of genotoxic, antigenotoxic and cytotoxic potential of the extract from lichen Cetraria aculeata (Schreb.) Fr. in vitro

Zeytinoğlu

İncesu

Tüylü

et al. 2007

Phytotherapy Research

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Naturally occurring compounds can have protective effects towards mutagens and carcinogens as shown by numerous studies. In the present study, the genotoxic/antigenotoxic activities of the extract from lichen Cetraria aculeata (Schreb.) Fr., which has been identified as an antibacterial agent in former studies, were investigated against known mutagens such as 4-nitro-o-phenylenediamine (4-NPD) and 2-aminofluorene (2-AF) in TA98 and TA100 strains of Salmonella typhimurium in the presence or absence of metabolic activity. Further genotoxicity/ antigenotoxicity of the extract against mitomycin C for micronucleus formation was also evaluated in human lymphocytes. The cytotoxic effects of the extract on mammalian cells were investigated in three different cell line types by MTT assay. The results obtained show that the extract of C. aculeata has a significant antigenotoxic activity in bacterial systems, but not in mammalian cells and cytotoxic activity in some mammalian cancer cells. However, it was not mutagenic in all systems. The findings suggest that the lichen extract may have a possible therapeutic potential and therefore this must be further investigated by other multiple in vitro bioassays for the development of therapeutic agents.

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“…subuliformis was evaluated, and the researchers observed that ethyl acetate and chloroform extracts had cytotoxic effects 72 h after the treatment in HeLa cells (Manojlović et al 2010). The extracts of 69 lichens species were evaluated in terms of their biological activities, and lichen extracts demonstrated antimicrobial, antiviral and cytotoxic activities (Perry et al 1999). In a study, the cytotoxic activities of eight lichen extracts were investigated in vitro using two murine and four human cancer cell lines (Bezivin et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Promising anticancer activity of a lichen, Parmelia sulcata Taylor, against breast cancer cell lines and genotoxic effect on human lymphocytes

et al. 2014

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Plants are still to be explored for new anticancer compounds because overall success in cancer treatment is still not satisfactory. As a new possible source for such compounds, the lichens are recently taking a great attention. We, therefore, explored both the genotoxic and anti-growth properties of lichen species Parmelia sulcata Taylor. The chemical composition of P. sulcata was analyzed with comprehensive gas chromatography-time of flight mass spectrometry. Anti-growth effect was tested in human breast cancer cell lines (MCF-7 and MDA-MB-231) by the MTT and ATP viability assays, while the genotoxic activity was studied by assays for micronucleus, chromosomal aberration and DNA fragmentation in human lymphocytes culture. Cell death modes (apoptosis/necrosis) were morphologically assessed. P. sulcata inhibited the growth in a dose-dependent manner up to a dose of 100 lg/ml and induced caspase-independent apoptosis. It also showed genotoxic activity at doses ([125 lg/ml) higher than that required for apoptosis. These results suggest that P. sulcata may induce caspase-independent apoptotic cell death at lower doses, while it may be genotoxic at relatively higher doses.

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Antimicrobial, Antiviral and Cytotoxic Activity of New Zealand Lichens

Cited by 96 publications

References 24 publications

HPLC Analysis of Usnic Acid in SomeRamalina. Species from Anatolia and Investigation of their Antimicrobial Activities

HPLC Analysis of Usnic Acid in SomeRamalina. Species from Anatolia and Investigation of their Antimicrobial Activities

Determination of genotoxic, antigenotoxic and cytotoxic potential of the extract from lichen Cetraria aculeata (Schreb.) Fr. in vitro

Promising anticancer activity of a lichen, Parmelia sulcata Taylor, against breast cancer cell lines and genotoxic effect on human lymphocytes

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