Antimicrobial Applications of Transition Metal Complexes of Benzothiazole Based Terpolymer: Synthesis, Characterization, and Effect on Bacterial and Fungal Strains

Ahamed, Mohamed A. Riswan; Azarudeen, Raja S.; Kani, N. Mujafar

doi:10.1155/2014/764085

Cited by 33 publications

(12 citation statements)

References 33 publications

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“…Materials containing metal–polymer complexes possess intriguing mechanical and catalytic properties. Their potential applications include ion-conducting solid membranes used in batteries, semiconducting materials, pharmacological applications such as antibacterial and anti-inflammatory drugs, membranes for artificial organs, polymer catalysts, materials with tunable mechanical strength, and wastewater management . These materials contain metal atoms, which form reversible coordination bonds with polymer ligands ( e.g.…”

Section: Introductionmentioning

confidence: 99%

Elucidating the Effects of Metal Complexation on Morphological and Rheological Properties of Polymer Solutions by a Dissipative Particle Dynamics Model

et al. 2018

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When a salt is added to a polymer solution, metal cations may coordinate with polymer ligands forming interchain and intrachain links. Metal coordination leads to drastic changes of polymer morphology, formation of clusters, and, ultimately, a sol−gel transition that affect the solution rheology. Although metal coordination is ubiquitous in polymeric systems, the physical mechanisms of coordination-induced morphological and rheological changes are still poorly understood due to the multiscale nature of this phenomenon. Here, we propose a coarse-grained dissipative particle dynamics (DPD) model to study morphological and rheological properties of concentrated solutions of polymers in the presence of multivalent cations that can coordinate the polymer ligands. The coordinating metal is introduced as a 3D complex of planar, tetrahedral, or octahedral geometry with the central DPD bead representing the metal cation surrounded at the vertices by either four or six dummy beads representing coordination sites, some of which are occupied by counterions to provide electroneutrality of the complex. Coordination is modeled as the dynamic formation and dissociation of a reversible link between the vacant coordination site and a ligand described by the Morse potential. The proposed model is applied to study the specifics of the equilibrium morphology and shearing flow in polyvinylpyrrolidone−dimethylformamide solutions in the presence of metal chlorides. Coordination leads to interchain and intrachain cross-links as well as to metal cations grafted onto polymer chains by a single link. The interchain cross-links induce a sol−gel transition to a weak gel phase as the metal concentration increases. Because of the reversible nature of interchain cross-links, the weak gel phase behaves as a viscoelastic fluid, the viscosity of which gradually increases with the metal concentration and decreases as the shear rate increases. The change of viscosity due to interchain coordination cross-links scales with the interchain cross-link density and the metal concentration according to the power law with the exponent ν ≈ 1.15. The influence of the grafted metal atoms on the viscosity is found to be much weaker, while the effect of the intrachain cross-links is found to be negligible. The simulation results are in qualitative agreement with available literature data. The proposed DPD model provides a physical insight into the morphological features of polymer solutions in the presence of multivalent slats and can be extended to other coordinating systems such as metal-substituted polyelectrolytes.

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Section: Introductionmentioning

confidence: 99%

Elucidating the Effects of Metal Complexation on Morphological and Rheological Properties of Polymer Solutions by a Dissipative Particle Dynamics Model

et al. 2018

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“…The prepared discs were dipped within a specified variation of free ligand, in addition to the complexes located within petri plates containing a nutrient medium sowed through every bacterial and fungal serum individually. Every plate was incubated for 24 and 48 h for the bacteria, as well as fungi, at 37 °C; furthermore, the zone of inhibition values were noted [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

Synthesis, Spectral Characterization and Biological Activities of Co(II) and Ni(II) Mixed Ligand Complexes

Manimaran¹,

Balasubramaniyan²,

Azam

et al. 2021

Molecules

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2,4-Dinitrophynylhydrazine and two thiocyanate ions in a (M:L1:L2) 1:2:2 molar ratio was synthesized in the complexes of Co(II) and Ni(II). The prepared compounds were identified through a C.H.N.S. analysis, conductivity measurements, powder X-ray diffraction (PXRD), the infrared spectrum, and a UV-visible spectrum analysis, in addition to the magnetic properties being measured. The measurements of the molar conductance implieda nonelectrolytic nature of compounds Co(II) and Ni(II). The magnetic susceptibility, as well as electronic spectra, represented all the metal complexesthroughoctahedral geometry, respectively. The PXRD patterns suggested that all the complexes were an orthorhombic system with unit cell parameters. The in-vitro biological activity of the ligand and the metal complexes were screened against the Gram-positive and negative pathogenic bacteria Staphylococcus aureus, Bacillus subtilis, Pseudomonas, aeruginosa and Escherichia coli, as well as the fungal species of Aspergillusniger and Candida albicans.Thus, the metal complexes showeda high efficiency of antimicrobial activity compared with the ligand. Furthermore, applications of the ligand, as well as the metal complexes, were tested for in-vitro antioxidant potential in aDPPH assay. The results showed that the activity of the metal complexes with the in-vitro antioxidant was more active than that of 2,4-dinitrophenylhydrazine(DNPH).

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“…P. Jana et al [28] reported that the peaks resonating at 3.2-2.4 ppm in the aminated carboxymethyl guar gum is due to protons of ethylenediamine. M. A. R. Ahamed reported that the signal obtained at 5.08 ppm in aminated polymer is assigned to -NH protons of ethylenediamine [31]. In the NMR spectra of niacin inulin complex prominent peaks arise from 9-7.5 ppm because of the protons at ortho, meta and para positions of the aromatic ring of niacin molecule.…”

Section: H-nmr Spectroscopymentioning

confidence: 99%

Inulin–Niacin Conjugates: Preparation, Characterization, Kinetic and In Vitro Release Studies

et al. 2021

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Niacin, an essential B-complex vitamin, used in the treatment of nonalcoholic fatty liver disease is the rst perceived lipid regulating medication, inhibits and reverses hepatic steatosis and in ammation in animals and liver cell cultures. Niacin shows bene cial effects on adiposity. Niacin plays an important role in DNA repair, electron transfer, one-carbon metabolism and fatty acid synthesis in cells. Natural polysaccharides with desirable chemical modi cations can be combined with vitamins for developing the supplement treatment for vitamin de ciency disorders. Modi cation of inulin was carried out by tosylation, amination and then conjugated with niacin. Structural elucidation of the derivatives and conjugates was carried out by FT-IR, 1 H NMR and SEM. Thermal behavior was investigated by TGA and DSC techniques. The release and kinetics of niacin, from the conjugate, at different pH was studied. The release was observed to be pH dependent, showing a greater release at higher pH following Korsmeyer-Peppas kinetic model. Polysaccharide based approach was used for the preparation of stable niacininulin conjugates with controllable and prolonged release of niacin. These types of conjugates may be useful as vitamin delivery systems for vitamin de ciency disorders.

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Antimicrobial Applications of Transition Metal Complexes of Benzothiazole Based Terpolymer: Synthesis, Characterization, and Effect on Bacterial and Fungal Strains

Cited by 33 publications

References 33 publications

Elucidating the Effects of Metal Complexation on Morphological and Rheological Properties of Polymer Solutions by a Dissipative Particle Dynamics Model

Elucidating the Effects of Metal Complexation on Morphological and Rheological Properties of Polymer Solutions by a Dissipative Particle Dynamics Model

Synthesis, Spectral Characterization and Biological Activities of Co(II) and Ni(II) Mixed Ligand Complexes

Inulin–Niacin Conjugates: Preparation, Characterization, Kinetic and In Vitro Release Studies

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