Antimicrobial cerium ion-chitosan crosslinked alginate biopolymer films: A novel and potential wound dressing

Kaygusuz, Hakan; Torlak, Emrah; Akın-Evingür, Gülşen; Özen, İlhan; Klitzing, Regine von; Erim, F. Bedia

doi:10.1016/j.ijbiomac.2017.07.144

Cited by 95 publications

(41 citation statements)

References 29 publications

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“…Chitosan is a natural non-toxic biopolymer with many advantages such as low toxicity, high susceptibility to biodegradation, mucoadhesive nature, capacity to enhance drug permeability and absorption, and antimicrobial and antifungal activity (Qi et al, 2004). Therefore, Ce 3+ ions and chitosan with alginate films (Ce-Chi films) could act as wound dressing materials, showing an increasing reduction in CFU counts of E. coli and S. aureus during the 3-h exposure period (Kaygusuz et al, 2017). It was also reported that NPs with Ce and CeO 2 blended with chitosan (hybrid Chi-CeO 2 ) had enhanced antimicrobial activity.…”

Section: Polymer Matrixes Containing Cerium and Cerium Oxidementioning

confidence: 99%

Cerium and Its Oxidant-Based Nanomaterials for Antibacterial Applications: A State-of-the-Art Review

Zheng

et al. 2020

Front. Mater.

118

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Infectious diseases caused by bacteria remain a serious and global problem in human health. Herein, the discovery and application of antibiotics, which has attracted much attention in the past years, has helped to cure numerous infectious diseases and made huge contributions in the biomedical field. However, the widespread use of the broad-spectrum antibiotics has led to serious drug resistance for many human bacterial pathogens. In particular, bacterial drug resistance decreases therapeutic effects and leads to high mortality. Inspiringly, the introduction of nanomaterials in the biomedical field makes it possible to overcome the difficulty in bacterial drug resistance attributed to their unique antibacterial mechanism. Recently, a variety of metal-and metal oxide-based nanomaterials have been fully integrated in antibacterial applications and achieved excellent performances. Among them, cerium-and cerium oxide-based nanomaterials have received much attention worldwide. Remarkably, cerium oxide nanoparticles with lower toxicity act as effective antibacterial agents owing to their unique functional mechanism against pathogens through the reversible conversion of oxidation state between Ce(III) and Ce(IV). This article provides an overview of the state-of-the-art design and antibacterial applications of cerium-and cerium oxidebased materials. The first part discusses the underlying antibacterial mechanisms for cerium-and cerium oxide-based materials currently applied in biomedicine. The second part focuses on various antibacterial-related materials and their applications. In addition, the existing problems and future perspectives of the cerium-and cerium oxide-based materials make up the third part of this review. This paper could provide the possible mechanisms for antibacterial activities, various designs of cerium-and cerium oxide-based materials, and related antibacterial properties.

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Section: Polymer Matrixes Containing Cerium and Cerium Oxidementioning

confidence: 99%

Cerium and Its Oxidant-Based Nanomaterials for Antibacterial Applications: A State-of-the-Art Review

Zheng

et al. 2020

Front. Mater.

118

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“…The Ag-loaded scaffolds showed a strong bactericidal activity against the studied species, but caused cytotoxicity in fibroblasts. The Se-loaded scaffolds were shown to be membranolytic against the studied strains and were non-toxic towards fibroblast Kaygusuz et al compared the antibacterial properties of cerium (III) crosslinked alginate films (Ce films) and cerium (III)-chitosan crosslinked alginate films (Ce-Chi films), with conventional calcium alginate films, against Escherichia coli (Gram-negative bacteria) and Staphylococcus aureus (Gram-positive bacteria) [91]. The results showed that Ce and Ce-Chi films had higher antibacterial activity than films with calcium.…”

Section: Wound Dressingsmentioning

confidence: 99%

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Souto

Ribeiro

Ferreira

et al. 2020

IJMS

102

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Burn wounds are highly debilitating injuries, with significant morbidity and mortality rates worldwide. In association with the damage of the skin integrity, the risk of infection is increased, posing an obstacle to healing and potentially leading to sepsis. Another limitation against healing is associated with antibiotic resistance mainly due to the use of systemic antibiotics for the treatment of localized infections. Nanotechnology has been successful in finding strategies to incorporate antibiotics in nanoparticles for the treatment of local wounds, thereby avoiding the systemic exposure to the drug. This review focuses on the most recent advances on the use of nanoparticles in wound dressing formulations and in tissue engineering for the treatment of burn wound infections.

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“…Biopolymers suffer from poor mechanical properties that can be overcome by combining them with synthetic polymers [ 11 ]. Some of the biopolymers that are utilized in the preparation of wound dressings include hyaluronic acid (HA), alginate [ 12 ], dextran, elastin, cellulose [ 8 ], chitosan [ 13 ], fibrin, chitin, collagen, gelatin, etc. [ 8 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

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Antimicrobial cerium ion-chitosan crosslinked alginate biopolymer films: A novel and potential wound dressing

Cited by 95 publications

References 29 publications

Cerium and Its Oxidant-Based Nanomaterials for Antibacterial Applications: A State-of-the-Art Review

Cerium and Its Oxidant-Based Nanomaterials for Antibacterial Applications: A State-of-the-Art Review

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

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