Antimicrobial dihydrobenzofurans and xanthenes from a foliar endophyte of Pinus strobus

Richardson, Susan N.; Nsiama, Tienabe K.; Walker, Allison K.; McMullin, David; Miller, J. David

doi:10.1016/j.phytochem.2015.07.009

Cited by 37 publications

(29 citation statements)

References 43 publications

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“…Exploration of endophytic fungi have gained increased interest among scientist as these microorganisms produce biologically-active compounds with therapeutic values (Zhao et al, 2009;Santiago et al, 2012;do Nascimento et al, 2015;Richardson et al, 2015). Many of the compounds have been reported to produce bioactive compounds against various types of cancer cell lines (Chui et al, 2011;Zheng et al, 2013;Zhu et al, 2013;Chen et al, 2015;Wang et al, 2015 …”

Section: Introductionmentioning

confidence: 99%

Pyrophen Produced by Endophytic Fungi Aspergillus sp Isolated from Piper crocatum Ruiz & Pav Exhibits Cytotoxic Activity and Induces S Phase Arrest in T47D Breast Cancer Cells

Astuti¹,

Erden²,

Wahyono³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Section: Introductionmentioning

confidence: 99%

Pyrophen Produced by Endophytic Fungi Aspergillus sp Isolated from Piper crocatum Ruiz & Pav Exhibits Cytotoxic Activity and Induces S Phase Arrest in T47D Breast Cancer Cells

Astuti¹,

Erden²,

Wahyono³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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“…These microorganisms can promote and regulate the growth of host plants or produce special secondary metabolites by mediating or assisting host plants. 15 Some of these chemical components promote increase of the resistance for the medical plants, 16 and some others are used as effective medical components for the prevention and treatment of human diseases. 17,18 Notably, certain microbes may enter the human gut through oral administration, which may affect the intestinal flora.…”

mentioning

confidence: 99%

Insights into traditional Chinese medicine-microbe interaction using traditional Chinese medical microecology

Lai

Huang

2018

IJCAM

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“…Foliar endophytes of conifers are ubiquitous and phylogenetically diverse, and their functional roles in the forest ecosystem are largely unknown. The production of antimicrobial and antiinsectan secondary metabolites by conifer endophyte strains from the Acadian Forest Region suggests hosts may be conferred some tolerance to attack by pathogens and pests , Sumarah et al 2010, Richardson et al 2015, Tanney et al 2016b.…”

Section: Conifer Endophytes: Ubiquitous Complex and Diversementioning

confidence: 99%

“…Endophytes operate along the endosymbiont-pathogen continuum, with reports of species or strains providing conditionally mutualistic benefits to the host such as drought-tolerance or protection from pathogens or pests (Gange et al 2012, Hubbard et al 2014. Foliar endophytes of conifer trees limit the impact of host pests by the production of antiinsectan (Findlay et al 2003, Sumarah et al 2005) and antifungal (Sumarah et al 2011, Richardson et al 2015 metabolites. The positive effect of endophytic infection is illustrated by the in planta production of the dimeric anthraquinone rugulosin by Phialocephala scopiformis, a needle endophyte of Picea spp., which delays the larval development of the destructive pest Choristoneura fumiferana (Eastern spruce budworm) .…”

Section: Introductionmentioning

confidence: 99%

“…The positive effect of endophytic infection is illustrated by the in planta production of the dimeric anthraquinone rugulosin by Phialocephala scopiformis, a needle endophyte of Picea spp., which delays the larval development of the destructive pest Choristoneura fumiferana (Eastern spruce budworm) . Previous investigations into the mycological and chemical diversity of foliar endophytes in the Acadian Forest Region have resulted in the discovery of novel biologically active metabolites from unidentified or undescribed fungi (Sumarah et al 2008b, Sumarah et al 2010, Richardson et al 2015.…”

Section: Introductionmentioning

confidence: 99%

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A Taxonomic and Phylogenetic Investigation of Conifer Endophytes of Eastern Canada

Tanney¹

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Research interest in endophytic fungi has increased substantially, yet is the current research paradigm capable of addressing fundamental taxonomic questions?More than half of the ca. 30,000 endophyte sequences accessioned into GenBank are unidentified to the family rank and this disparity grows every year. The problems with identifying endophytes are a lack of taxonomically informative morphological characters in vitro and a paucity of relevant DNA reference sequences. A study involving ca. 2,600Picea endophyte cultures from the Acadian Forest Region in Eastern Canada sought to address these taxonomic issues with a combined approach involving molecular methods, classical taxonomy, and field work. It was hypothesized that foliar endophytes have complex life histories involving saprotrophic reproductive stages associated with the host foliage, alternative host substrates, or alternate hosts. Based on inferences from phylogenetic data, new field collections or herbarium specimens were sought to connect unidentifiable endophytes with identifiable material. Approximately 40 endophytes were connected with identifiable material, which resulted in the description of four novel genera and 21 novel species and substantial progress in endophyte taxonomy. Endophytes were connected with saprotrophs and exhibited reproductive stages on non-foliar tissues or different hosts. These results provide support for the foraging ascomycete hypothesis, postulating that for some fungi endophytism is a secondary life history strategy that facilitates persistence and dispersal in the absence of a primary host. This thesis provides an alternate approach to identifying endophytes by considering the whole fungus interacting within its natural habitat.iii Acknowledgements I would first like to thank my supervisor Dr. Keith A. Seifert for providing me with the freedom and support to conduct the research presented in this thesis as well as many other side projects and curiosities. Keith generously provided many opportunities to travel to domestic and international conferences, which made me more aware of the directions of global mycological research and provided the opportunity to meet many of the great mycological heroes and their contemporaries. Our discussions over the last five years have contributed to my development as a more well-rounded and openminded researcher, professional, and person; his honesty and integrity are qualities that all professionals should aspire to have. I am indebted to Keith for the knowledge, experience, and personal growth I gained over the last five years in his lab. I thank Dr. J. David Miller for providing stimulating discourse, travel and collecting opportunities, and of course the unique opportunity to work on this project, which proved to be an exciting and captivating experience. I hope that we can continue collaborating on this and other projects in the near future. Myron Smith provided support and advice throughout this process. The Carleton University Graduate Administrators Darlene Moss and Lisa Chiarel...

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Antimicrobial dihydrobenzofurans and xanthenes from a foliar endophyte of Pinus strobus

Cited by 37 publications

References 43 publications

Pyrophen Produced by Endophytic Fungi Aspergillus sp Isolated from Piper crocatum Ruiz & Pav Exhibits Cytotoxic Activity and Induces S Phase Arrest in T47D Breast Cancer Cells

Pyrophen Produced by Endophytic Fungi Aspergillus sp Isolated from Piper crocatum Ruiz & Pav Exhibits Cytotoxic Activity and Induces S Phase Arrest in T47D Breast Cancer Cells

Insights into traditional Chinese medicine-microbe interaction using traditional Chinese medical microecology

A Taxonomic and Phylogenetic Investigation of Conifer Endophytes of Eastern Canada

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