2016
DOI: 10.7314/apjcp.2016.17.2.615
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Pyrophen Produced by Endophytic Fungi Aspergillus sp Isolated from Piper crocatum Ruiz & Pav Exhibits Cytotoxic Activity and Induces S Phase Arrest in T47D Breast Cancer Cells

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Cited by 11 publications
(12 citation statements)
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“…Previous study reported that pyrophen isolated from endopytic fungi Aspergillus fumigatus KARSV04 showed toxicity towards p53 defective breast cancer cell T47D. 16 Further exploration on its potency to kill other breast cancer cell was examined by observing its toxicity towards p53 competent cells MCF-7 cells. In this study we found that pyrophen showed cytotoxity towards MCF-7.…”
Section: Discussionmentioning
confidence: 99%
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“…Previous study reported that pyrophen isolated from endopytic fungi Aspergillus fumigatus KARSV04 showed toxicity towards p53 defective breast cancer cell T47D. 16 Further exploration on its potency to kill other breast cancer cell was examined by observing its toxicity towards p53 competent cells MCF-7 cells. In this study we found that pyrophen showed cytotoxity towards MCF-7.…”
Section: Discussionmentioning
confidence: 99%
“…Similar finding was found upon treating T47D with this compound alone. 16 On the other hand, it is indicated that pyrophen increased G2/M The difference response upon treatment of T47D and MCF-7 cells with pyrophen might be explained by the fact that these two breast cancer cell line have different characteristics in that T47D cells are p53 defective mutants whilst MCF-7 bearing p53 wildtype. 21 The accumulation of T47D cells in S phase may be in part due to inability of cells to promote p53 dependent cell death and rely on S phase arrest following treatment of pyrophen.…”
Section: Discussionmentioning
confidence: 99%
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