Antimicrobial dressings: Comparison of the ability of a panel of dressings to prevent biofilm formation by key burn wound pathogens

Halstead, Fenella D.; Rauf, Maryam; Bamford, Amy; Wearn, Christopher M.; Bishop, Jonathan; Burt, R.; Fraise, A.P.; Moiemen, Naiem; Oppenheim, Beryl; Webber, Mark A.

doi:10.1016/j.burns.2015.06.005

Cited by 69 publications

(33 citation statements)

References 34 publications

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“…In a series of in vitro tests, Halstead et al 61 determined the ability of antimicrobial dressings (including Mepilex Ag), two non-antimicrobial dressings and acetic acid (AA) (used successfully to treat burn wounds infected or heavily colonised with P. aeruginosa) to prevent isolates of P. aeruginosa (PS_PA01 and PS_1586) and Acinetobacter baumannii (ACI_AYE and ACI_721) forming biofilms. A crystal violet biofilm formation assay was used to assess the test agents' ability to prevent biofilm formation.…”

Section: Pseudomonas Aeruginosa Staphylococcus Aureus Candida Albicansmentioning

confidence: 99%

Silver-containing foam dressings with Safetac: a review of the scientific and clinical data

Davies

McCarty

Hamberg³

2017

J Wound Care

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Phil Davies has more than 25 years of experience of working in healthcare-related industries. During that time, he has authored and contributed to numerous peer-reviewed journal articles and conference presentations (oral and poster) relating to wound care and other areas of healthcare. Phil was awarded a BSc (Hons) Medical Cell Biology and Biochemistry by the University of Liverpool (United Kingdom) in 1989.Sara McCarty was awarded her BSc (Hons) in biomedical sciences in 2008 by the University of Chester, UK. Since then, Sara has gained research experience in the field of wound healing. As a medical writer, she has also authored and contributed to a number of peer-reviewed journal articles and conference presentations. In 2014, she was awarded a PhD in the role and control of matrix metalloproteases in cutaneous wound healing.Kristina Hamberg has over 10 years of experience of working with the design and development of wound care products, particularly those with antimicrobial properties. During that time, she has become an expert within the areas of microbiology and test method development, as well as infection prevention. Kristina was awarded her MSc in food science in 1997 from the University of Kalmar, Sweden, and in 2002 she was awarded a PhD for microbiological evaluation of novel technologies for food preservation by Chalmers Technical University, Gothenburg, Sweden.How to cite this document: Davies, P., McCarty, S., Hamberg, K. Silver-containing foam dressings with Safetac: a review of the scientific and clinical data. J Wound Care 2017; 26: 6 (Suppl. 1), S1-S32. Conclusion S24 References S27Downloaded from magonlinelibrary.com by 054

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Section: Pseudomonas Aeruginosa Staphylococcus Aureus Candida Albicansmentioning

confidence: 99%

Silver-containing foam dressings with Safetac: a review of the scientific and clinical data

Davies

McCarty

Hamberg³

2017

J Wound Care

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“…In the past years, silver has been increasingly used in cosmetics, clothes, implant coatings, and for burn wound dressings, to obtain an antibacterial effect17181920. Its inherent toxicity makes the metal a particularly promising alternative to antibiotics, as bacterial resistances rise2122, as well as an anti-cancer agent232425.…”

mentioning

confidence: 99%

Fluorescence-tunable Ag-DNA biosensor with tailored cytotoxicity for live-cell applications

Bossert

Bruin

Götz

et al. 2016

Sci Rep

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DNA-stabilized silver clusters (Ag-DNA) show excellent promise as a multi-functional nanoagent for molecular investigations in living cells. The unique properties of these fluorescent nanomaterials allow for intracellular optical sensors with tunable cytotoxicity based on simple modifications of the DNA sequences. Three Ag-DNA nanoagent designs are investigated, exhibiting optical responses to the intracellular environments and sensing-capability of ions, functional inside living cells. Their sequence-dependent fluorescence responses inside living cells include (1) a strong splitting of the fluorescence peak for a DNA hairpin construct, (2) an excitation and emission shift of up to 120 nm for a single-stranded DNA construct, and (3) a sequence robust in fluorescence properties. Additionally, the cytotoxicity of these Ag-DNA constructs is tunable, ranging from highly cytotoxic to biocompatible Ag-DNA, independent of their optical sensing capability. Thus, Ag-DNA represents a versatile live-cell nanoagent addressable towards anti-cancer, patient-specific and anti-bacterial applications.

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“…We investigated 3 wound dressings containing silver (Acticoat™, Mepilex ® Ag, and Urgotul ® SSD) and 2 without silver (Suprathel ® and Vaseline Gauze™). These dressings had already been investigated in preclinical studies regarding their adverse effects on cells, 21,22,40,41 bacteria, [42][43][44] created wounds, 45,46 and in clinical applications. [47][48][49][50][51][52][53] At day 10 we observed a graft take of 100%.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Wound Dressings on a Bio-Engineered Human Dermo-Epidermal Skin Substitute in a Rat Model

Hüging

Biedermann

Sobrio

et al. 2017

Journal of Burn Care & Research

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Autologous bio-engineered dermo-epidermal skin substitutes are a promising treatment for large skin defects such as burns. For their successful clinical application, the graft dressing must protect and support the keratinocyte layer and, in many cases, possess antimicrobial properties. However, silver in many antimicrobial dressings may inhibit keratinocyte growth and differentiation. The purpose of our study was to evaluate the effect of various wound dressings on the healing of a human hydrogel-based dermo-epidermal skin substitute in preparation for the first-in-human clinical trials. Human dermo-epidermal skin substitutes approved for clinical trials were produced under good manufacturing practice conditions, transplanted onto immuno-incompetent rats, and dressed with either Vaseline Gauze™ (Kendall Medtronic, Minneapolis, USA), Suprathel (PolyMedics Innovations GmbH, Denkendorf, Germany), Urgotul SSD (Urgo Medical, Shepshed, United Kingdom), Mepilex AG (Mölnlycke Health Care, Gothenburg, Sweden), or Acticoat™ (Smith&Nephew, Baar, Switzerland). Grafts were assessed clinically for take, epithelialization, and infection at 10 and 21 days post-transplantation, and histologically at 21 days. There were three subjects each in the Vaseline Gauze™ and Suprathel groups, and four subjects each in the Urgotul SSD, Mepilex AG, and Acticoat™ groups. For all samples, the take rate was 100% and the expected keratinocyte number, epithelialization and epidermal stratification were observed. All of the dressings in the current study were well tolerated by our human dermo-epidermal skin substitute. The tolerance of the silver-based dressings is particularly relevant given the high risk of bacterial contamination with large skin defects, and provides pivotal information as we embark on clinical trials for this novel skin substitute.

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Antimicrobial dressings: Comparison of the ability of a panel of dressings to prevent biofilm formation by key burn wound pathogens

Cited by 69 publications

References 34 publications

Silver-containing foam dressings with Safetac: a review of the scientific and clinical data

Silver-containing foam dressings with Safetac: a review of the scientific and clinical data

Fluorescence-tunable Ag-DNA biosensor with tailored cytotoxicity for live-cell applications

The Effect of Wound Dressings on a Bio-Engineered Human Dermo-Epidermal Skin Substitute in a Rat Model

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