2012
DOI: 10.3201/eid1803.100878
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Antimicrobial Drug Resistance in Peru

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2012
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Cited by 23 publications
(19 citation statements)
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“…[2][3][4] All of the above may result in the selection and development of antibiotic resistance not only to antibiotics such as ampicillin or cotrimoxazole, but also to the most modern fluoroquinolones or cephalosporins. [5][6][7] Quinolone resistance has traditionally been related to chromosomal mutations in drug target genes, gyrA and gyrB (encoding DNA Gyrase), parC and parE (encoding Topoisomerase IV), and overexpression of efflux pumps or decreased expression of outer membrane porins. 8 Of these, amino acid substitutions at GyrA and ParC are by far the most important mechanisms of quinolone resistance in clinical isolates.…”
Section: Introductionmentioning
confidence: 99%
“…[2][3][4] All of the above may result in the selection and development of antibiotic resistance not only to antibiotics such as ampicillin or cotrimoxazole, but also to the most modern fluoroquinolones or cephalosporins. [5][6][7] Quinolone resistance has traditionally been related to chromosomal mutations in drug target genes, gyrA and gyrB (encoding DNA Gyrase), parC and parE (encoding Topoisomerase IV), and overexpression of efflux pumps or decreased expression of outer membrane porins. 8 Of these, amino acid substitutions at GyrA and ParC are by far the most important mechanisms of quinolone resistance in clinical isolates.…”
Section: Introductionmentioning
confidence: 99%
“…En el Instituto de Enfermedades Neoplásicas de Lima, en 2005 se reportó una frecuencia de 40,78% en aislamientos de E. coli y K. pneumoniae (13). En 2012 la publicación de García et al (14), mostró que el 75,1% de E. coli y el 76,8% K. pneumoniae, de aislamientos recuperados de bacteriemias eran productores de BLEE.…”
Section: Discussionunclassified
“…En el caso de E. coli productora de BLEE, Colombia se situaría a nivel de Europa con una prevalencia intermedia. En comparación con los países vecinos, los datos reportados por Bantar, et al, (17) y García, et al, (64) sugieren que en Colombia la frecuencia del fenotipo BLEE en E. coli estaría por debajo de la detectada en Venezuela, Argentina y Chile, y en K. pneumoniae, se ubicaría después de Perú (75 % de cepas con producción de BLEE) (64), Venezuela (58 % de resistencia) y Argentina, pero con mayor frecuencia de resistencia que Chile.…”
Section: Discussionunclassified