Antimicrobial drug use in hospitalised paediatric patients: a cross-national comparison between Germany and Croatia

Ufer, Mike; Radošević, Nives; Vogt, Anja; Palčevski, Goran; Francetić, Igor; Reinalter, Stephan C.; Seyberth, H. W.; Vlahović‐Palčevski, Vera

doi:10.1002/pds.1108

Cited by 19 publications

(15 citation statements)

References 15 publications

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“…Although not restricted, these broad‐spectrum β‐lactams were not prescribed as extensively in Tartu, Vilnius and Huddinge as they were in Rijeka. In comparison, a Norwegian study reported low use of third‐generation cephalosporins [20], while studies from the Mediterranean region have shown a greater proportion of broad‐spectrum antimicrobial use [21–23]. Results from the European Surveillance on Antimicrobial Consumption (ESAC) project for outpatient antibiotic use have shown a higher consumption, especially of broad‐spectrum antimicrobial agents, in southern and eastern Europe than in northern Europe [24].…”

Section: Discussionmentioning

confidence: 99%

“…Although not restricted, these broadspectrum b-lactams were not prescribed as extensively in Tartu, Vilnius and Huddinge as they were in Rijeka. In comparison, a Norwegian study reported low use of third-generation cephalosporins [20], while studies from the Mediterranean region have shown a greater proportion of broad-spectrum antimicrobial use [21][22][23].…”

Section: Discussionmentioning

confidence: 99%

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Benchmarking antimicrobial drug use at university hospitals in five European countries

Vlahović‐Palčevski

Dumpis

Mitt

et al. 2007

Clinical Microbiology and Infection

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A point-prevalence survey of five European university hospitals was performed to benchmark antimicrobial drug use in order to identify potential problem areas in prescribing practice and to aid in establishing appropriate and attainable goals. All inpatients at the university hospitals of Rijeka (Croatia), Tartu (Estonia), Riga (Latvia), Vilnius (Lithuania) and Karolinska-Huddinge (Sweden) were surveyed for antimicrobial drug use during a single day. The frequency of antimicrobial drug use was 24% in Rijeka, 30% in Tartu, 26% in Riga, 14% in Vilnius and 32% in Huddinge. Surgical patients were treated with antimicrobial agents more often than medical patients in Riga (53% vs. 31%), Tartu (39% vs. 26%) and Vilnius (54% vs. 25%). Two-thirds of patients in Rijeka, Tartu, Riga and Vilnius, and fewer than half of the patients in Huddinge, received antimicrobial agents intravenously. Broad-spectrum antimicrobial agents were used most commonly in Rijeka. The prevalence of nosocomial infections treated with antibiotics was 9% at Huddinge, and 3-5% at the other centres. Benchmarking antimicrobial drug use at five university hospitals identified differences and problem areas. The high rates of intravenous administration, poor compliance with guidelines, and prolonged surgical prophylaxis were general problems that deserved specific attention at all centres. A change in prescription practices may reduce unnecessary drug use and decrease antimicrobial resistance.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Benchmarking antimicrobial drug use at university hospitals in five European countries

Vlahović‐Palčevski

Dumpis

Mitt

et al. 2007

Clinical Microbiology and Infection

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“…The method and parameters to be compared were identified from previous point prevalence surveys conducted across Europe 13 15–20. The following data were collected: demographic details including gender, age and specialty, prescribed antibiotic(s), indication, dose, frequency, route of administration and day of treatment.…”

Section: Methodsmentioning

confidence: 99%

Comparison of antimicrobial prescribing between two specialist paediatric centres in the UK and Latvia

2013

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“…This is considered to be the main reason why microorganisms isolated from hospital infections show more resistant profiles than microorganisms from community infections [17]. Various hospital PPSs on antimicrobial use were carried out in the last three decades [18][19][20][21][22]. Also these PPS varied greatly in aims, protocols and populations surveyed, thus making comparison of their results difficult.…”

Section: Introductionmentioning

confidence: 99%

The European Centre for Disease Prevention and Control (ECDC) pilot point prevalence survey of healthcare-associated infections and antimicrobial use

et al. 2012

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A standardised methodology for a combined point prevalence survey (PPS) on healthcare-associated infections (HAIs) and antimicrobial use in European acute care hospitals developed by the European Centre for Disease Prevention and Control was piloted across Europe. Variables were collected at national, hospital and patient level in 66 hospitals from 23 countries. A patient-based and a unit-based protocol were available. Feasibility was assessed via national and hospital questionnaires. Of 19,888 surveyed patients, 7.1% had an HAI and 34.6% were receiving at least one antimicrobial agent. Prevalence results were highest in intensive care units, with 28.1% patients with HAI, and 61.4% patients with antimicrobial use. Pneumonia and other lower respiratory tract infections (2.0% of patients; 95% confidence interval (CI): 1.8-2.2%) represented the most common type (25.7%) of HAI. Surgical prophylaxis was the indication for 17.3% of used antimicrobials and exceeded one day in 60.7% of cases. Risk factors in the patient-based protocol were provided for 98% or more of the included patients and all were independently associated with both presence of HAI and receiving an antimicrobial agent. The patient-based protocol required more work than the unit-based protocol, but allowed collecting detailed data and analysis of risk factors for HAI and antimicrobial use.

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Antimicrobial drug use in hospitalised paediatric patients: a cross-national comparison between Germany and Croatia

Abstract: A shorter treatment duration, less variation in the prescribing pattern and a greater adherence to the use of recommended antimicrobials argue for a more rational antimicrobial drug use in Marburg than in Rijeka. However, a further identification of drug choice determinants is warranted.

Cited by 19 publications

References 15 publications

Benchmarking antimicrobial drug use at university hospitals in five European countries

Benchmarking antimicrobial drug use at university hospitals in five European countries

Comparison of antimicrobial prescribing between two specialist paediatric centres in the UK and Latvia

The European Centre for Disease Prevention and Control (ECDC) pilot point prevalence survey of healthcare-associated infections and antimicrobial use

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