Antimicrobial drug utilization pattern in neonatal sepsis in a tertiary care hospital

Abstract

Objective: The objective of this study was to determine antimicrobial drug use in newborns at a tertiary care neonatal intensive care unit, to identify educational/research priorities in neonatal drug therapy. Materials and Methods: This prospective observational study included 713 patients of neonatal sepsis over a period of 18 months. Data like name, age, sex, birth weight, gestational age, antibiotics used were recorded in the previously prepared case record form. Results: Number of patients admitted in early neonatal period was 467(65.5%) and number of patients admitted in late neonatal period was 246(34.5%). The mean age of all patients being admitted in NICU was 6.23 ± 5.86 days. The majority of neonates (92.56%) were prescribed 2 to 5 antibiotics and 29.59% of neonates were prescribed 2 antibiotics. Average number of antibiotics of all patients being admitted was 3.74 ± 1.38. Most frequently used antibiotics in decreasing frequency were: Amikacin (97.19%), ampicillin + sulbactam (60.17%), vancomycin (57.64%), ceftazidime (38.71%), cefotaxime (34.22%), ciprofloxacin (26.23%), piperacillin + tazobactam (19.07%). 73% drugs were given by generic name and 53.33% drugs were prescribed from the essential drug list. Mean length of stay in NICU of all patients being admitted was 7.59 ± 5.66 days. Conclusion: The present study provides valuable insight about the overall pattern of antimicrobial drug use profile in patients of neonatal sepsis of a tertiary care hospital. It is intended to be a step in broader evaluation of safety and efficacy of drug prescription in neonatal sepsis patients.

Bacteriological Profile and Antibiotic Susceptibility Patterns of Sepsis-Causing Bacteria at the Neonatal Intensive Care Unit of a Tertiary Health Care Facility in Ghana

“…Comparatively, the mean duration of stay on admission in this study (3.6 ± 4.8 days) was lower than the earlier mean duration of stay of 7.6 ± 5.7 days on admission reported by Vaniya et al 26 However, other authors have reported a mean duration of stay as high as 22 days. 27 Neonatal sepsis is considered a clinical emergency, with its management having an implication for the neonate’s lifelong survival.…”

Predictors of the onset of neonatal sepsis at the Neonatal Intensive Care Unit of a tertiary hospital in Ghana: A cross‐sectional study

“…In this study, the mean duration of stay on admission was lower than the earlier mean duration of stay reported by Vaniya et al 37 Other authors have reported a mean duration of stay as high as 22 days. 38 Neonatal sepsis is considered a clinical emergency, with its management implying the neonate's lifelong survival.…”

Pharmacoepidemiology of Antimicrobial Agents in Neonatology: Results of the Retrospective Cross-Sectional Study

“…Обсуждение дополнительных результатов исследования В целом, большинство исследований из различных регионов мира свидетельствует, что в ОРИТ новорожден-ных антибиотики получают до 100% пациентов (особенно глубоконедоношенных) [15][16][17], что показано и в нашем исследовании. В международной практике антибактери-альной терапии одной из основных тенденций является также стремление к сокращению объема потребления [19].…”