Antimicrobial effect and biocompatibility of novel metallic nanocrystalline implant coatings

Gosau, Martin; Haupt, Michael; Thude, Sibylle; Strowitzkí, Martin; Schminke, Boris; Buergers, Ralf

doi:10.1002/jbm.b.33376

Cited by 48 publications

(32 citation statements)

References 29 publications

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“…Ion implantation allows the modulation of surface properties of a polymer, including its biocompatibility. The increase in biocompatibility can be attributed, among other things, to an increased polarity of the modified surface and the presence of oxygen-rich groups, as well as to an increase in its roughness, which leads to an increase in surface area [52]. The adhesion of cells to a substrate is mediated by bonding via electrostatic forces but also via specific molecules of the extracellular matrix [53].…”

Section: Ion Implantationmentioning

confidence: 99%

Surface Modification of Polymer Substrates for Biomedical Applications

2017

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While polymers are widely utilized materials in the biomedical industry, they are rarely used in an unmodified state. Some kind of a surface treatment is often necessary to achieve properties suitable for specific applications. There are multiple methods of surface treatment, each with their own pros and cons, such as plasma and laser treatment, UV lamp modification, etching, grafting, metallization, ion sputtering and others. An appropriate treatment can change the physico-chemical properties of the surface of a polymer in a way that makes it attractive for a variety of biological compounds, or, on the contrary, makes the polymer exhibit antibacterial or cytotoxic properties, thus making the polymer usable in a variety of biomedical applications. This review examines four popular methods of polymer surface modification: laser treatment, ion implantation, plasma treatment and nanoparticle grafting. Surface treatment-induced changes of the physico-chemical properties, morphology, chemical composition and biocompatibility of a variety of polymer substrates are studied. Relevant biological methods are used to determine the influence of various surface treatments and grafting processes on the biocompatibility of the new surfaces—mammalian cell adhesion and proliferation is studied as well as other potential applications of the surface-treated polymer substrates in the biomedical industry.

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Section: Ion Implantationmentioning

confidence: 99%

Surface Modification of Polymer Substrates for Biomedical Applications

2017

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“…Besides silver, other inorganic agents, such as copper, fluorine, and zinc have been introduced as potential antimicrobial agents in dental implant coatings.…”

Section: Peri‐implantitis Prevention: Antimicrobial Coatingsmentioning

confidence: 99%

“…111 Silver has a wide spectrum of antibacterial susceptibility, a low propensity for bacterial resistance, and the ability to inhibit polymicrobial colonization. 112 Silver can be introduced to dental implants through various techniques such as magnetron sputtering, 113,114 plasma immersion ion implantation, [115][116][117] or physical vapor deposition. 115,118 Silver can also be incorporated into glasses and ceramic materials including phosphates, silicate glasses, and hydroxyapatite.…”

Section: Nonantibiotic Antimicrobial Coatingsmentioning

confidence: 99%

“…120,122 Silver nanoparticles deposited by anodic spark deposition in combination with a solution containing silicon, calcium, phosphorus, and sodium for a biomimetic coating on titanium substrates was able to reduce bacterial adhesion and provide osteointegrative properties. 123 Besides silver, other inorganic agents, such as copper, 113,124 fluorine, 125,126 and zinc 15,124 have been introduced as potential antimicrobial agents in dental implant coatings.…”

Section: Nonantibiotic Antimicrobial Coatingsmentioning

confidence: 99%

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Current state‐of‐the‐art and future perspectives of the three main modern implant‐dentistry concerns: Aesthetic requirements, mechanical properties, and peri‐implantitis prevention

López‐Píriz

Cabal

Goyos‐Ball³

et al. 2019

J Biomedical Materials Res

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The idea of permanent tooth replacement goes back to the year 2000 BC at least, when carved bamboo pegs were used to replace missing teeth in ancient China. The phenomenon of osseointegration, however, was not verified until the mid‐1960s, when Branemark discovered that titanium could integrate to bone. Since then, the osseointegration capacity of implants has been profoundly investigated and implants as such have evolved enormously in all possible aspects, from material selection and processing to specific surface engineering, among many others. This review article, in particular, focuses on dental implants and aims to introduce the main concerns involved in modern dentistry, concentrating especially on the importance of finding an effective way to prevent peri‐implantitis. In this sense, strategies such as shifting from metal to ceramic implant components and applying novel antimicrobial antibiotic‐free coatings seem to be taking the lead. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2019.

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“…ity [George et al, 1994;Chen et al, 2010;Gosau et al, 2016]. Due to the increase in antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) [Klein et al, 2016;Kavanagh et al, 2017], there is a pressing need to find alternative, low-cost antibacterial agents to which there is little resistance.…”

mentioning

confidence: 99%

Whey Protein Complexes with Green Tea Polyphenols: Antimicrobial, Osteoblast-Stimulatory, and Antioxidant Activities

Carson

Keppler

Brackman

et al. 2018

Cells Tissues Organs

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Polyphenols are known for their antimicrobial activity, whilst both polyphenols and the globular protein β-lactoglobulin (bLG) are suggested to have antioxidant properties and promote cell proliferation. These are potentially useful properties for a tissue-engineered construct, though it is unknown if they are retained when both compounds are used in combination. In this study, a range of different microbes and an osteoblast-like cell line (human fetal osteoblast, hFOB) were used to assess the combined effect of: (1) green tea extract (GTE), rich in the polyphenol epigallocatechin gallate (EGCG), and (2) whey protein isolate (WPI), rich in bLG. It was shown that approximately 20–48% of the EGCG in GTE reacted with WPI. GTE inhibited the growth of Gram-positive bacteria, an effect which was potentiated by the addition of WPI. GTE alone also significantly inhibited the growth of hFOB cells after 1, 4, and 7 days of culture. Alternatively, WPI significantly promoted hFOB cell growth in the absence of GTE and attenuated the effect of GTE at low concentrations (64 µg/mL) after 4 and 7 days. Low concentrations of WPI (50 µg/mL) also promoted the expression of the early osteogenic marker alkaline phosphatase (ALP) by hFOB cells, whereas GTE inhibited ALP activity. Therefore, the antioxidant effects of GTE can be boosted by WPI, but GTE is not suitable to be used as part of a tissue-engineered construct due to its cytotoxic effects which negate any positive effect WPI has on cell proliferation.

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Antimicrobial effect and biocompatibility of novel metallic nanocrystalline implant coatings

Cited by 48 publications

References 29 publications

Surface Modification of Polymer Substrates for Biomedical Applications

Surface Modification of Polymer Substrates for Biomedical Applications

Current state‐of‐the‐art and future perspectives of the three main modern implant‐dentistry concerns: Aesthetic requirements, mechanical properties, and peri‐implantitis prevention

Whey Protein Complexes with Green Tea Polyphenols: Antimicrobial, Osteoblast-Stimulatory, and Antioxidant Activities

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