Antimicrobial Effect of Chitosan against Periodontal Pathogens Biofilms

A significant antibiofilm and antimicrobial activity of chitosan-polyacrylic acid nanoparticles against pathogenic bacteria

“…According to the data from the light microscopy test, CS-PAA nanoparticles obstruct the biofilm layer and exhibit actual potential inhibition. Similarly, chitosan nanoparticles containing various chitosan types, such as low- and high-molecular mass chitosan substances, had an antibacterial action that prevented the growth of bacterial biofilms ( Pintado, 2014 ).…”

Antioxidant, anti-inflammatory and antimicrobial activity of natural products in periodontal disease: a comprehensive review

“…Within the group of molecules, chitosan has demonstrated in vitro, a potent effect against periodontal pathogens through a diverting effect on bacterial coaggregation, inhibiting biofilm formation, and an anti-inflammatory activity, through modulation of the fibroblastic inflammatory response (Arancibia et al, 2013;Costa et al, 2014). However, its antioxidant capacity is believed to be limited, so it is necessary to potentiate it with certain compounds (Lunkov et al, 2020;Zhao et al, 2022).…”

“…It has antibacterial activity against both Gram-positive and Gramnegative bacteria, albeit its efficiency against one or the other is debatable (Hosseinnejad and Jafari, 2016;Ardean et al, 2021). Costa et al (2014) studied in vitro the antimicrobial effect of chitosan on five biofilm-forming periodontal pathogens (Porphyromonas gingivalis, Prevotella intermedia, Prevotella buccae, Tanerella forsythensis and Aggregatibacter actinomycetemcomitans) and found that chitosan showed a strong effect against periodontal path-ogens through interference in bacterial co-aggregation, by inhibiting Clostridium vilaceum violacein, thus inhibiting biofilm formation. In vitro, Arancibia et al (2013) found that chitosan particles can limit the growth of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans as well as regulate the inflammatory response of human gingival fibroblasts.…”

Chitosan improves the efficacy of gentamicin against MDR and biofilm-forming URO pathogenic E. coli

“…Another previous study was conducted by (Breser et al, 2018), where the MIC of chitosan combined with cloxacillin against Staphylococcus was 0.125 and 0.25, respectively indeed, LMW chitosan's antibacterial activity has been related to its interaction with electronegative chemicals in the bacterial cell's core. (Costa et al, 2014). Chitosan activity is influenced by a variety of factors, where molecular weight and the type of microorganisms evaluated play important roles (Verlee et al, 2017).…”