Antimicrobial effects of Ag/TiO2 compound coatings and ZnO films on titanium based surface

Liao, WeiSha; Lai, Chunhua; Chang, Yin-Yu; Huang, Heng‐Li; Hsu, Jia-Wei

doi:10.1007/978-3-642-03891-4_8

Cited by 2 publications

(1 citation statement)

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“…The mechanism of action of boric acid is inhibition of oxidative metabolism causing a decrease in production of cellular ergosterol and interfering in hyphae transformation by inhibiting apical growth through cytoskeletal disruption 19 . Zinc oxide acts by generating reactive oxygen species (ROS), producing damage to the cell and the cellular components through oxidative stress 20,21 . The individual activity of BA, TR and ZO has been described, but the increasing or potentiating effect of the antimicrobial activity by combination of these compounds is unknown.…”

Section: Introductionmentioning

confidence: 99%

Antifungal activity of boric acid, triclosan and zinc oxide against different clinically relevant Candida species

Gavilanes-Martínez

Coral-Garzón

Cáceres

et al. 2021

Mycoses

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Background The genus Candida includes about 200 different species, but only a few are able to produce disease in humans. The species responsible for the highest proportion of human infections is Candida albicans. However, in the last two decades there has been an increase in the proportion of infections caused by other Candida species, including C. glabrata (Nakaseomyces glabrata), C. parapsilosis, C. tropicalis, C. krusei (Pichia kudriavzevi) and more recently C. auris. Decolonisation of patients has been used as an infection control strategy for bacterial infections, but information about decolonisation products used in clinical practice for Candida and other fungal pathogens is limited. Compounds with antimicrobial activity, such as triclosan (TR), boric acid (BA) and zinc oxide (ZO), are mainly used in personal care products. These products can be used for long periods of time without an abrasive skin effect and are a possible alternative for patient decolonisation in healthcare settings. Objective The aim of this study was to evaluate the antifungal activity of boric acid (BA), triclosan (TR) and zinc oxide (ZO), individually and combined, against clinically relevant Candida species. Materials and methods Compounds to be screened for antifungal activity were evaluated at different concentrations, alone, and combined, using a well diffusion assay. The statistical evaluation was performed using analysis of variance (ANOVA) and a post hoc analysis using the multiple comparisons method. Results Individually, BA and TR showed antifungal activity against all Candida species evaluated but ZO did not show any antifungal activity. Mixtures of BA [5%]—TR [0.2%]; BA [5%]—TR [0.3%]; BA [5%]—TR [0.2%]—ZO [8.6%]; and BA [5%]—TR [0.2%]—ZO [25%] yielded the highest antifungal activity. An increased antifungal effect was observed in some mixtures when compared with individual compounds. Conclusions We demonstrated antifungal activity of BA and TR against multiple Candida species, including against a clade of the emerging healthcare‐associated pathogen C. auris. Additionally, this study shows enhancement of the antifungal effect and no antagonism among the mixtures of these compounds. Further research is needed to determine whether these compounds can reduce the burden of Candida on skin.

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Section: Introductionmentioning

confidence: 99%