Antimicrobial effects of esters and amides of 3-(5-nitro-2-furyl)acrylic acid

Kellová, G.; Šturdı́k, Ernest; Štibrányi, Ladislav; Drobnica, L; Augustín, Jozef

doi:10.1007/bf02875905

Cited by 10 publications

(2 citation statements)

References 12 publications

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“…5-Nitro-2-furylacrylic acid (NFAA) (1) was obtained from Slovakofarma Hlohovec (Czechoslovakia). Alkyl esters and amides of NFAA (2)(3)(4)(5)(6)(7)(8)(9) were synthesized according to Sturdik et al (13,14). Nitrovin (9) was obtained from Chemapol Praha (Czechoslovakia), and nitrofurantoin (10) (o-Nitrophenyl)-/3-D-galactopyranoslde (ONPG) and p -nltrophenyl phosphate (PNPP) are the substrates for determination of the enzymes -galactosldase and alkaline phosphatase, respectively.…”

Section: Methodsmentioning

confidence: 99%

Use of specific bacteria for the determination of mutagenic and carcinogenic compounds

Miertus¹,

Šturdı́k²,

Vojteková³

1987

Anal. Chem.

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Possibilities of the use of Escherichia coll K-12 In the determination of mutagenic compounds have been tested. Analytical parameters, e.g., the range of linearity of the analytical curve, the detection limit and the sensitivity, the accuracy, and the precision of analysis, have been evaluated for a series of nitrofurans. The detection limit Is In the range of 10~7-10~* mol L~\ Analyses of real samples (determination of 5-nHro-2-furylacryllc acid In wine and nitrovin In chicken meat) have been completed without any preseparation.

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Section: Methodsmentioning

confidence: 99%

Use of specific bacteria for the determination of mutagenic and carcinogenic compounds

Miertus¹,

Šturdı́k²,

Vojteková³

1987

Anal. Chem.

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“…However, novel antibacterial compounds with more selectivity and less toxicity are needed for the future. The necessity for novel specific antibacterial drugs is evidenced by the microorganisms' development of resistance to drugs. − For this reason many researchers worldwide have been interested in the search and evaluation of novel antimicrobial compounds. − Specifically, our center has been working fundamentally in synthesis, biological testing, and development of antibacterial drugs from nitrovinylfuran compounds. − These chemicals have been known for a long time to have antimicrobial and other activities. − Hence, the broad diversity of possible chemical structures to test imposed on us the necessity for development of an alternative technique to classical trial and error screenings.…”

Section: Introductionmentioning

confidence: 99%

Designing Antibacterial Compounds through a Topological Substructural Approach

Molina

González-Dı́az

González

et al. 2004

J. Chem. Inf. Comput. Sci.

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A novel application of TOPological Substructural MOlecular DEsign (TOPS-MODE) was carried out in antibacterial drugs using computer-aided molecular design. Two series of compounds, one containing antibacterial and the other containing non-antibacterial compounds, were processed by a k-means cluster analysis in order to design training and predicting series. All clusters had a p-level < 0.005. Afterward, a linear classification function has been derived toward discrimination between antibacterial and non-antibacterial compounds. The model correctly classifies 94% of active and 86% of inactive compounds in the training series. More specifically, the model showed a global good classification of 91%, i.e., 263 cases out of 289. In predicting series, the model has shown overall predictabilities of 91 and 83% for active and inactive compounds, respectively. Thereby, the model has a global percentage of good classification of 89%. The TOPS-MODE approach, also, similarly compares with respect to one of the most useful models for antimicrobials selection reported to date.

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Novel Analogues of Sydnone: Synthesis, Characterization and Antibacterial Evaluation

Moustafa

Gineinah

Nasr

et al. 2004

Archiv der Pharmazie

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New sydnone derivatives bearing a substituted phenyl ring at the 3‐position have been synthesized. Two separate series of 3‐(carboxyphenyl)sydnone derivatives have been prepared by cyclization of the corresponding N‐nitroso‐N‐(carboxyphenyl)‐glycine 3. The obtained 3‐(carboxyphenyl)sydnones 4 were subjected to a series of different chemical reactions on the carboxylic acid group. Compound 5, the potassium salt of 4a, was reacted with α‐chloroacetanilide derivatives 6 to give the corresponding esters 7. On the other hand, the acid hydrazide 9 was condensed with different aromatic aldehydes to give the corresponding arylidene derivatives 10. The synthesized compounds were tested for their antibacterial activities against both gram‐positive and gram‐negative organisms. Some of the test compounds exhibited high activity; among them, 10d is considered to be a lead compound possessing high broad‐spectrum antibacterial activity.

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Antimicrobial effects of esters and amides of 3-(5-nitro-2-furyl)acrylic acid

Cited by 10 publications

References 12 publications

Use of specific bacteria for the determination of mutagenic and carcinogenic compounds

Use of specific bacteria for the determination of mutagenic and carcinogenic compounds

Designing Antibacterial Compounds through a Topological Substructural Approach

Novel Analogues of Sydnone: Synthesis, Characterization and Antibacterial Evaluation

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