Antimicrobial Effects of Native Chitosan against Opportunistic Gram-negative Bacteria

Batista, Anabelle Camarotti de Lima; Dantas, Gautam; Santos, João Victor de Oliveira; Amorim, Rosa

doi:10.3923/mj.2011.105.112

Cited by 18 publications

(3 citation statements)

References 19 publications

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“…The results of Batista et al are similar in that they observed the highest inhibitory effect of chitosan against E. coli and Lactobacillus casei at a pH value of 5.7 ( L. casei ) and 5.5 ( E. coli ) [161]. While testing the antifungal activity of LMW chitosan against several species of clinical isolates of Candida sp., Alburquenque et al observed an increased inhibitory effect at a pH value of 4.0, with the MIC being up to 4 times lower than at neutral pH.…”

Section: Factors Influencing Chitosan’s Antimicrobial Effectmentioning

confidence: 88%

“…They have tested two types of chitosan (HMW and LMW) against E. coli (Gram-negative), L. casei , and multiresistant strain S. aureus (both Gram-positive). Only MMW chitosan was antibacterially active, and only against E. coli and L. casei , while S. aureus was resistant to both chitosan samples [161]. As shown in Table 2, many other studies reported similar data regarding the MW of chitosan and chitosan derivatives.…”

Section: Factors Influencing Chitosan’s Antimicrobial Effectmentioning

confidence: 96%

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Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action

Matica

Aachmann

Tøndervik

et al. 2019

IJMS

538

275

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Fighting bacterial resistance is one of the concerns in modern days, as antibiotics remain the main resource of bacterial control. Data shows that for every antibiotic developed, there is a microorganism that becomes resistant to it. Natural polymers, as the source of antibacterial agents, offer a new way to fight bacterial infection. The advantage over conventional synthetic antibiotics is that natural antimicrobial agents are biocompatible, non-toxic, and inexpensive. Chitosan is one of the natural polymers that represent a very promising source for the development of antimicrobial agents. In addition, chitosan is biodegradable, non-toxic, and most importantly, promotes wound healing, features that makes it suitable as a starting material for wound dressings. This paper reviews the antimicrobial properties of chitosan and describes the mechanisms of action toward microbial cells as well as the interactions with mammalian cells in terms of wound healing process. Finally, the applications of chitosan as a wound-dressing material are discussed along with the current status of chitosan-based wound dressings existing on the market.

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Section: Factors Influencing Chitosan’s Antimicrobial Effectmentioning

confidence: 88%

Section: Factors Influencing Chitosan’s Antimicrobial Effectmentioning

confidence: 96%

Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action

Matica

Aachmann

Tøndervik

et al. 2019

IJMS

538

275

View full text Add to dashboard Cite

show abstract

“…S. aureus (a Gram-positive bacterium that is the most common pathogen found in biomaterial associated infections) and E. coli (a Gram-negative bacterium commonly present in human organism) were used as model bacteria to evaluate the antimicrobial properties of the UP:macLA-IEMA films [30]. For this purpose, a modified Kirby-Bauer technique was used to characterize the antimicrobial properties of the bioadhesives.…”

Section: Evaluation Of the Antibacterial Activity Of The Filmsmentioning

confidence: 99%

Preparation of biodegradable functionalized polyesters aimed to be used as surgical adhesives

Cernadas

Gonçalves

Alves

et al. 2019

European Polymer Journal

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The study and development of new biocompatible materials to be applied as UV-curable adhesives is extremely important to grant the preparation of matrices with suitable mechanical, biological and thermal properties with a fast curing rate. Herein, photocrosslinkable biodegradable copolymers composed of unsaturated polyesters (UP) and lactic acid oligomers functionalized with 2-isocyanatoethyl methacrylate (IEMA) were produced. Henceforth, three different stoichiometric proportions were tested, which, after the addition of a biocompatible photoinitiator (Irgacure® 2959), resulted in flexible, resistant and uniform matrices after 2 minutes and 30 seconds of crosslinking.The synthesized materials were then further characterized in terms of chemical composition and thermal/mechanical behaviour. The gel content, dynamic contact angles, water sorption capacity and hydrolytic degradation were also assessed. The biocompatibility and antibacterial activity of the produced materials was also evaluated.Taking into account all the data obtained, it may be concluded that the new synthesized biodegradable bioadhesives present promising properties to be used as surgical adhesives.

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Chitosan

Batista¹,

Paiva²,

Neto³

2021

Polysaccharides of Microbial Origin

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Antimicrobial Effects of Native Chitosan against Opportunistic Gram-negative Bacteria

Cited by 18 publications

References 19 publications

Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action

Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action

Preparation of biodegradable functionalized polyesters aimed to be used as surgical adhesives

Chitosan

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