Antimicrobial evaluation of mangiferin analogues

Abstract

The naturally occurring xanthone glycoside mangiferin has been isolated by column chromatography from the ethanol extract of stem bark of Mangifera indica. Mangiferin was further converted to 5-(N-phenylaminomethyleno)mangiferin, 5-(N-p-chlorophenylaminomethyleno) mangiferin, 5-(N-2-methylphenylaminomethyleno) mangiferin, 5-(N-p-methoxyphenylaminomethyleno) mangiferin, 5-(N, N-diphenylaminomethyleno) mangiferin, 5-(N--napthylaminomethyleno) mangiferin and 5-(N-4-methylphenylaminomethyleno) mangiferin. Mangiferin and its analogues were characterized by melting point and Rf value determination and through spectral technique like UV, IR, and NMR spectral analysis. The synthesized compounds were screened for antimicrobial activity.

Comparative Pharmacokinetic Study of Mangiferin in Normal and Alloxan-Induced Diabetic Rats after Oral and Intravenous Administration by UPLC-MS/MS

“…1). Mangiferin has been reported to possess biological activities against oxidation [1], bacteria [2], tumor [3], al- lergy [4], human immunodeficiency virus [5], neurodegradation [6], and hyperlipidemia [7].…”

INVESTIGAÇÃO DA ATIVIDADE ANTIFÚNGICA DE Mangifera indica L. FRENTE A DIFERENTES ESPÉCIES DE Candida ssp. ASSOCIADAS À CANDIDÍASE VULVOVAGINAL

“…Singh et al (2009) registraram atividade antimicrobiana do composto mangerin, isolado de caule, e seus aná-logos sintéticos frente às espécies Staphylococcus aureus, Escherichia coli e Aspergillus niger. Esses mesmos autores apontam que o análogo sintético de mangerin, 5-(N-α-napthylaminomethyleno), inibiu o crescimento da espécie C. albicans, entre tanto não foi testado a CIM.…”

Thermal Degradation Kinetics and pH-Rate Profiles of Iriflophenone 3,5-C-β-d-diglucoside, Iriflophenone 3-C-β-d-Glucoside and Mangiferin in Aquilaria crassna Leaf Extract

“…Compounds 1-3 are polyphenols from natural origins that play important bioactive roles, such as being an antioxidant for compounds 1-3 [14], being antimicrobial [17] and having anti-inflammatory [14,18] and vasorelaxant [16] properties for compound 3. Previous reports have indicated that there is evidence supporting the correlation between the phenolic contents in plant extracts and their bioactivity properties.…”

“…It has been noted that the plant extracts that exhibit significant antioxidant capabilities have good potential as antimicrobials [19]. Several phenolic compounds, such as luteolin, myricetin [20] and compound 3 [17], showed antibacterial activity. To understand the appropriate conditions for maintaining the quality of the plant extract to ensure a high level of phenolic contents and their activities, the kinetic model was used to establish and control the plant extract quality.…”