ANTIMICROBIAL EVALUATION OF SESQUITERPENE Α-Curcumene AND ITS SYNERGISM WITH IMIPENEM

Silva, Gloria Narjara Santos da; Pozzatti, Patrícia; Rigatti, Fabiane; Hörner, Rosmari; Alves, Sydney Hartz; Mallmann, Carlos Augusto; Heinzmann, Berta Maria

doi:10.15414/jmbfs.2015.4.5.434-436

Cited by 29 publications

(5 citation statements)

References 6 publications

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“…Which means it may attenuate Parkinson's disease (Balakrishnan et al, 2018). The compound α-curcumene, have antimicrobial activity, Pozzatti et al (2015) concluded that fungal strains are more sensitive for α-curcumene than the bacterial ones. Elemicin inhibited the bacterial growth of NCTC 11168 strain (Rossi et al, 2007).…”

Section: Essential Oils (Eo) Yieldmentioning

confidence: 99%

Chemical compositions and biological activities of the essential oils from gamma irradiated celery (Apium graveolens L.) seeds

El-Beltagi

Dhawi

Aly

et al. 2020

Not Bot Horti Agrobo

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Celery seed oils can help in detoxification processes of the body as it facilitates the elimination of toxins and other harmful substances out of the body. This study aimed to assess biological activity of essential oils extracted from un-irradiated and irradiated celery seeds by gamma rays. Celery seeds were irradiated with different dose levels of gamma radiation; control, 2.5, 5.0, and 10.0 kGy. The highest increase of essential oil extracted was registered with a dosage level of 10.0 kGy (2.42%). The GC-MS analysis showed that, there were new compounds detected in the irradiated samples and others compounds were increased or decreased. The FTIR spectra showed alterations in functional groups of essential oils extracted from celery seeds upon gamma-irradiation. Total phenols, total flavonoids and antioxidant activity increased proportional to the increase in the irradiation dose level and the maximum increase obtained in the irradiation dose level 10.0 kGy. This may be an evidence on the biological value, there were anticancer activity against 2 cell lines, breast cancer cell line (MCF-7) and lung cancer cell line (A549). The best IC50 in A549 was 145 µg/ml in sample with irradiation dose level 5.0 kGy while the best IC50 in MCF-7 was 124 µg/ml in irradiated sample with dose 5.0 kGy. Also, the highest inhibition zone of S. aureus, B. subtilis and K. pneumoniae were obtained with the oil extracted from seeds irradiated with 5 kGy dose level, where E. coli and C. albicans were more pronounced for the oil gotten from the seeds irradiated with 10.0 kGy. The irradiation process for celery seeds may be promising for biological value of celery oils.

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Section: Essential Oils (Eo) Yieldmentioning

confidence: 99%

Chemical compositions and biological activities of the essential oils from gamma irradiated celery (Apium graveolens L.) seeds

El-Beltagi

Dhawi

Aly

et al. 2020

Not Bot Horti Agrobo

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“…Noticed mechanisms were inhibition of DNA replication as well as blocking of cellular respiration. Phytochemicals like choline ( Siopa et al, 2016 ), rhein ( Joung et al, 2012 ), limonene ( Vuuren and Viljoen, 2007 ), α-curcumene ( Santos da Silva et al, 2015 ), geraniol ( Lira et al, 2020 ), linalool ( Park S.-N. et al, 2012 ), camphor ( Masry et al, 2021 ), myrcene ( Chaves-Quirós et al, 2020 ), and α-pinene ( Dhar et al, 2014 ; Cloeckaert et al, 2015 ) which were earlier reported from Alternanthera pungens Kunth, may be responsible for such antimicrobial action.…”

Section: Introductionmentioning

confidence: 99%

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

et al. 2022

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Ethnopharmacological relevance: The genus Alternanthera (Amaranthaceae) comprises 139 species including 14 species used traditionally for the treatment of various ailments such as hypertension, pain, inflammation, diabetes, cancer, microbial and mental disorders.Aim of the review: To search research gaps through critical assessment of pharmacological activities not performed to validate traditional claims of various species of Alternanthera. This review will aid natural product researchers in identifying Alternanthera species with therapeutic potential for future investigation.Materials and methods: Scattered raw data on ethnopharmacological, morphological, phytochemical, pharmacological, toxicological, and clinical studies of various species of the genus Alternanthera have been compiled utilizing search engines like SciFinder, Google Scholar, PubMed, Science Direct, and Open J-Gate for 100 years up to April 2021.Results: Few species of Alternanthera genus have been exhaustively investigated phytochemically, and about 129 chemical constituents related to different classes such as flavonoids, steroids, saponins, alkaloids, triterpenoids, glycosides, and phenolic compounds have been isolated from 9 species. Anticancer, antioxidant, antibacterial, CNS depressive, antidiabetic, analgesic, anti-inflammatory, and immunomodulator effects have been explored in the twelve species of the genus. A toxicity study has been conducted on 3 species and a clinical study on 2 species.Conclusions: The available literature on pharmacological studies of Alternanthera species reveals that few species have been selected based on ethnobotanical surveys for scientific validation of their traditional claims. But most of these studies have been conducted on uncharacterized and non-standardized crude extracts. A roadmap of research needs to be developed for the isolation of new bioactive compounds from Alternanthera species, which can emerge out as clinically potential medicines.

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“…Major compounds like zingerone, 6-gingerol, 8-shogaol, 6-shogaol, nortrachelogenin, isocaryophyllene, β-elemene, carinol, trans-nerolidol, α-curcumene, α-zingiberene, β-curcumene might be responsible for the antibacterial activity of this plant, as the antibacterial activity of these compounds have already been reported [14][15][16][17][18][19][20][21].…”

Section: Resultsmentioning

confidence: 99%

Chemical Profiling and Antibacterial Efficacy of Different Ginger Accessions from Uttarakhand, India

Dhanik¹,

Verma²,

Arya³

et al. 2017

Asian J. Chem.

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ANTIMICROBIAL EVALUATION OF SESQUITERPENE Α-Curcumene AND ITS SYNERGISM WITH IMIPENEM

Cited by 29 publications

References 6 publications

Chemical compositions and biological activities of the essential oils from gamma irradiated celery (Apium graveolens L.) seeds

Chemical compositions and biological activities of the essential oils from gamma irradiated celery (Apium graveolens L.) seeds

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

Chemical Profiling and Antibacterial Efficacy of Different Ginger Accessions from Uttarakhand, India

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