Antimicrobial gold nanorods with dual-modality photodynamic inactivation and hyperthermia

Kuo, Wen Shuo; Chang, Chich Neng; Chang, Yi; Yeh, Chen Sheng

doi:10.1039/b907274h

Cited by 118 publications

(98 citation statements)

References 19 publications

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“…a semiconductor particle that is so small that it exhibits quantum mechanical properties), metal nanoparticles [161][162][163][164][165][166][167][168], liposomes, dendrimers [169][170][171][172][173], carbon nanotubes [174,175], and particles of silica and iron oxide [176][177][178][179]. In vivo efficacy of a phototheranostic is determined by factors such as the particle size and functionalization of the surface.…”

Section: Nanoparticles In Phototheranostic Agentsmentioning

confidence: 99%

“…Gold nanorods conjugated to toluidine blue photosensitizer (entry 21, Table 1) [161] were effective in photodynamic destruction of methicillin-resistant Staphylococcus aureus. Photodynamic destruction of this bacterium has been demonstrated also using nanoagents made by encapsulating the photosensitizer hematoporphyrin (Hp) in liposomes and micelles (entry 22, Table 1) [209].…”

Section: Treatment Of Microbial Infectionmentioning

confidence: 99%

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Applications of phototheranostic nanoagents in photodynamic therapy

et al. 2014

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Nanotherapeutics has an increasing role in the treatment of diseases such as cancer. In photodynamic therapy (PDT) a therapeutically inactive photosensitizer compound is selectively activated by light to produce molecules capable of killing diseased cells and pathogens. A phototheranostic agent can be defined as a single nanoentity with the capabilities for targeted delivery, optical imaging and photodynamic treatment of a disease. Malignant cells, tissue and microbial etiologic agents can be effectively targeted by PDT. Photodynamic therapy is noninvasive, or minimally invasive, and has few side effects as damage to healthy tissue is minimized and the killing effect is localized. Various forms of cancer, acne and other diseases may be treated. The in vivo efficacy of photosensitizers is further improved by attaching them to nanostructures capable of targeting the diseased site. Such photosensitizer-functionalized nanostructures, or nanotherapeutics, allow site-specific delivery of imaging and therapeutic agents for improved phototheranostic performance. This review explores the potential applications of phototheranostic nanostructures in diagnosis and therapy.

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Section: Nanoparticles In Phototheranostic Agentsmentioning

confidence: 99%

Section: Treatment Of Microbial Infectionmentioning

confidence: 99%

Applications of phototheranostic nanoagents in photodynamic therapy

et al. 2014

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“…In particular, it can increase the cellular uptake of oxygen molecules which is essential for PDT. Synthesis, characterization, cellular uptake and photodynamic activity of gold nanorods coupled to a photosensitizer have been described by Kuo et al (2009Kuo et al ( , 2010. They coated gold nanorods with a cetyltrimethylammonium bromide surfactant coating and conjugated indocyanine green (Fig.…”

Section: Purpurin-18 and 5-aminolevulinic Acid Gold Nanoparticles Conmentioning

confidence: 99%

Nanoparticles for Photodynamic Therapy Applications

Vanderesse

Frochot

Barberi‐Heyob

et al. 2011

Intracellular Delivery

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Photodynamic therapy has emerged as an alternative to chemo-and radiotherapy for the treatment of certain types of cancer. Nanoparticles have been used to improve the delivery and the efficiency of the photosensitizer as they allow its encapsulation without loss of activity. Using targeting strategies, they can also allow the selective accumulation of the photosensitizer in the cancer tissues. In this review, based on the chemical nature of the nanoparticles, the different methods for their syntheses are described from the pioneering works to the latest achievements. Indeed the nanosystems can be conjugated to a biomolecule or an antibody to target receptors over-expressed in cancer cells and/or angiogenic vascular endothelial cells. Numerous in vivo and in vitro applications have been described. Multifunctional nanoplatforms combining several applications within the same nano-object emerge as potential important theranostic tools.

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“…The extent to which the GNRs conjugated to anti-protein A antibody were absorbed in the vital organs GNRs conjugated to toluidine blue photosensitizer (Au-anionic poly(acrylic acid)-toluidine blue) showed its duality in a study conducted by Kuo et al on MRSA, determining both antimicrobial photodynamic inactivation and hyperthermia. 31 Following treatment with the abovementioned conjugate and sequential exposure to heliumneon laser (633 nm, 1 minute) and continuous wave laser (808 nm, 25 minutes), there was a significant reduction in MRSA viability (to about 5%) and a 10-fold increase in antimicrobial ability, compared to photodynamic antimicrobial chemotherapy or hyperthermia alone. There was no bacterial damage in the absence of nanorods after both types of laser therapies, but there was a decrease in viability to 59% and 53% following treatment with nanorods.…”

Section: Gold Nanorodsmentioning

confidence: 99%

“…There was no bacterial damage in the absence of nanorods after both types of laser therapies, but there was a decrease in viability to 59% and 53% following treatment with nanorods. 31 Effective biofilm disinfection was obtained in another study 32 using a GNR cluster that is easily excited by NIR laser irradiation, which generates heat rapidly through photothermal conversion. Wet chemistry was used for the synthesis of GNRs, and photolithography was used in the microfabrication of one GNR cluster.…”

Section: Gold Nanorodsmentioning

confidence: 99%