Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2′-bipyridyl complex on bacterial and fungal pathogens

Chandraleka, Saravanan; Ramya, K; Chandramohan, G.; Dhanasekaran, Dharumadurai; Aravind, Priyadharshini; Panneerselvam, A.

doi:10.1016/j.jscs.2011.11.020

Cited by 87 publications

(50 citation statements)

References 49 publications

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“…These macrocyclic monometallic complexes of Ge(IV) were then investigated against a number of microbial species. All the complexes were physicochemically characterized using elemental analysis, IR spectrum, 1 5 Cl 2 ]Cl 2 against Fusarium udum and Curvularia species was found to be better than that of commercially available fungicide dithane M-45. Our data indicated that these complexes were effective to combat the growth of selective drug resistant pathogenic microorganisms.…”

Section: Resultsmentioning

confidence: 99%

“…For practical utility of this compound, the inhibiting capacity of the complexes were compared with the commercially available fungicide, dithane-M-45 (a broad fungicide) which is used in the inhibition of spore germination in the 0.1 -0.2% in the field condition limit for many fungi. It was found that in the case of [Ge(OAML) 5 Cl 2 ]Cl 2 against Fusarium udum and Curvularia species, the effect of the complex was found to be better than that of commercially available fungicide dithane M-45. This observation is quite significant and opens, up a new field of research as the metal complex [Ge(OAML) 5 Cl 2 ]Cl 2 is better fungi toxic than commercial products, showing greater possibility of applicability of the complex under field conditions.…”

Section: Analysis Of Variance (Anova)mentioning

confidence: 99%

“…It was found that in the case of [Ge(OAML) 5 Cl 2 ]Cl 2 against Fusarium udum and Curvularia species, the effect of the complex was found to be better than that of commercially available fungicide dithane M-45. This observation is quite significant and opens, up a new field of research as the metal complex [Ge(OAML) 5 Cl 2 ]Cl 2 is better fungi toxic than commercial products, showing greater possibility of applicability of the complex under field conditions.…”

Section: Analysis Of Variance (Anova)mentioning

confidence: 99%

“…To overcome the alarming problem of microbial resistance to antibiotics, the discovery of novel active compounds against new targets is a matter of urgency [4]. Metal based drugs represent a novel group of antifungal agents with potential applications for the control of fungal and bacterial infections [5]. In view of biological importance of macrocyclic complexes, biological screening of the synthetic macrocyclic metal complexes has also been carried out [6].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization and Biological Activity of Monometallic Complexes of Germanium

Chaudhary¹,

Singh²,

Rawat³

2016

Int. J. Curr. Res. Chem. Pharm. Sci

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Monometallic Complexes of germanium(IV) with macrocyclic ligands have been synthesized and characterized by elemental analysis, molar conductance , infrared spectra, 1 H NMR and 13 C NMR spectral studies. The molar conductance of 10 −3 M solutions of these complexes at the room temperature indicates that the complexes are 1:2 electrolytes in nature. On the basis of chemical composition there presentation of the complexes as [Ge(OAML)nCl2]Cl2 (n=1-5) has been proposed. These synthesized complexes have also been tested against several species of pathogenic fungi and bacteria in order to evaluate their antimicrobial properties.

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Section: Resultsmentioning

confidence: 99%

Section: Analysis Of Variance (Anova)mentioning

confidence: 99%

Section: Analysis Of Variance (Anova)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis, Characterization and Biological Activity of Monometallic Complexes of Germanium

Chaudhary¹,

Singh²,

Rawat³

2016

Int. J. Curr. Res. Chem. Pharm. Sci

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“…Moreover, the chelating nature of the metal complex enhances the lipophilic property making the complex penetrate through bacterial lipid membrane [44]. According to overtone's concept of cell permeability, passage of metal complexes causing lipid solubility is a critical factor in antimicrobial activity [45]. The decrease in polarity of metal ion attributes to ligand orbital overlap and sharing of positive charge with the donor groups increases the hydrophobicity index of the hydrazine metal complex which further enhances its penetration into lipid membrane leading to cell death as stated.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Synthesis, characterization, thermal behavior and antimicrobial activity of 3-methyl benzoate complexes of transition metal with hydrazine

Mohanapriya¹,

Muthukumaran²,

Vairam³

2016

Bull. Chem. Soc. Eth.

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ABSTRACT. Reaction of the ligands, 3-methyl benzoic acid (mbH) and hydrazine with transition metal ions form the complexes of formulae, [M(N2H4)2(mb)2].H2O where M = Co(II) and Zn(II) at pH = 5-6, [M(N2H4)n(mb)2].xH2O where M = Ni(II), n = 2, x = 0 at pH = 5 and M = Cd, n = 1, x = 1 at pH = 6. The same acid also forms metal carboxylates with zinc and copper of formula, [Zn(mb)2H2O].H2O at pH = 6 and [Cu(mb)2].H2O at pH = 5, respectively. The IR spectra of the complexes show that hydrazine is present as bridging bidentate ligand and the carboxylic acid as monodentate bridging carboxylate anion. The electronic spectra, magnetic moments and ESR spectral data suggest the coordination number. Thermal studies show that cobalt, zinc and nickel complexes containing hydrazine, and carboxylates of copper, zinc on their thermal decomposition form the corresponding metal oxides in nano size in the temperature range 755-815 °C. The antibacterial and antifungal activity show that both activities of the complexes are higher than that of the acid and among the complexes, cadmium compound shows more antimicrobial activity towards bacteria and fungi.

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L‐argininato copper(II) complexes in solution exert significant selective anticancer and antimicrobial activities

Wojciechowska

Szuster‐Ciesielska

Sztandera

et al. 2020

Applied Organom Chemis

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A search for new drugs that overcome the multidrug resistance of microorganisms or are effective against cancer cells prompted us to investigate the binary and ternary Cu(II) complexes containing L-arginine, [CuCl(L-Arg)(phen)] Cl•2H 2 O (phen = 1,10-phenanthroline) (1) and [Cu(L-Arg) 2 (H 2 O)]C 2 O 4 •6H 2 O (2), for which crystal and molecular structures were characterized previously. In order to discuss the biological function, the complexes have been screened for their antitumor activity against A549 (human lung cancer cells), HepG2 (human liver hepatocellular carcinoma cells) and antimicrobial activity. To identify the complexes forms existing in the solutions of 1 and 2 crystals, the results obtained from EPR, NIR-Vis-UV and MS (mass spectrometry) measurements were correlated with those from analysis of potentiometric titration of Cu(II)-L-Arg and Cu(II)-L-Arg-phen systems. This comprehensive study indicated that the [Cu(L-Arg)(phen)] 2+ and [Cu(L-Arg) 2 ] 2+ species are dominant in the solution. Complexes 1 and 2 were found to present specific liganddependent cytotoxic and antiproliferative potential against cancer cells. They also show antibacterial activity against Gram-positive and Gram-negative bacteria as well as display antifungal properties.

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Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2′-bipyridyl complex on bacterial and fungal pathogens

Cited by 87 publications

References 49 publications

Synthesis, Characterization and Biological Activity of Monometallic Complexes of Germanium

Synthesis, Characterization and Biological Activity of Monometallic Complexes of Germanium

Synthesis, characterization, thermal behavior and antimicrobial activity of 3-methyl benzoate complexes of transition metal with hydrazine

L‐argininato copper(II) complexes in solution exert significant selective anticancer and antimicrobial activities

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