Antimicrobial medical sutures with caffeic acid phenethyl ester and their in vitro/in vivo biological assessment

Lee, Hye Sun; Lee, Soo-Youn; Lee, Jin Hyung; Ahn, Sang Kook; Choi, Young In; Choi, Doo Jin; Chang, Jeong Ho

doi:10.1039/c2md20289a

Cited by 21 publications

(11 citation statements)

References 37 publications

(39 reference statements)

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“…The report concluded octenidine‐coated sutures to be better than chlorhexidine based on their release kinetics, antimicrobial efficacy and host cytotoxicity . Another study, suggested the use of caffeic acid phenethyl ester loaded sutures to preventing infections . The antimicrobial effect was due to outer membrane damage and reactive oxygen species synthesis in bacteria .…”

Section: Recent and Emerging Trendsmentioning

confidence: 99%

“…Another study, suggested the use of caffeic acid phenethyl ester loaded sutures to preventing infections . The antimicrobial effect was due to outer membrane damage and reactive oxygen species synthesis in bacteria . Meanwhile, an in vitro study of quaternary ammonium compound (K21)‐coated sutures and dental floss showed dose‐dependent antimicrobial activity of bacterial species of direct relevance to infection and bacteremia …”

Section: Recent and Emerging Trendsmentioning

confidence: 99%

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Suture materials — Current and emerging trends

Christopher

Sethu

Nayak

et al. 2016

J Biomedical Materials Res

158

108

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Surgical sutures are used to facilitate closure and healing of surgical-or trauma-induced wounds by upholding tissues together to facilitate healing process. There is a wide range of suture materials for medical purpose and the main types include absorbable and nonabsorbable. Recently, there is a growth in the development of classes of suture materials based on their properties and capabilities to improve tissue approximation and wound closure. This review outlines and discusses the current and emerging trends in suture technology including knotless barbed sutures, antimicrobial sutures, bio-active sutures such as drug-eluting and stem cells seeded sutures, and smart sutures including elastic, and electronic sutures. These newer strategies expand the versatility of sutures from being used as just a physical entity approximating opposing tissues to a more biologically active component enabling delivery of drugs and cells to the desired site with immense application potential in both therapeutics and diagnostics.

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Section: Recent and Emerging Trendsmentioning

confidence: 99%

Section: Recent and Emerging Trendsmentioning

confidence: 99%

Suture materials — Current and emerging trends

Christopher

Sethu

Nayak

et al. 2016

J Biomedical Materials Res

158

108

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“…There is evidence that CAPE possesses promising fungicidal activity on fungi infecting tomato without causing any harm to the fruit [ 13 ]. Moreover, poly(lactic- co -glycolic acid) (PLGA) sutures containing CAPE have been proposed to have antibacterial activity against Staphylococcus aureus and Escherichia DH5 α bacteria; this activity of CAPE was attributed to the synthesis of reactive oxygen species (ROS) that destroy the outer membrane of bacteria [ 14 ]. In recent studies [ 15 – 17 ], CAPE has been proposed as a valuable inhibitor of HIV-1 integrase; therefore, this polyphenol is believed to be a potential anti-HIV therapy.…”

Section: Activities Of Capementioning

confidence: 99%

Caffeic Acid Phenethyl Ester and Therapeutic Potentials

Murtaza

Karim

Akram

et al. 2014

BioMed Research International

173

123

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Caffeic acid phenethyl ester (CAPE) is a bioactive compound of propolis extract. The literature search elaborates that CAPE possesses antimicrobial, antioxidant, anti-inflammatory, and cytotoxic properties. The principal objective of this review article is to sum up and critically assess the existing data about therapeutic effects of CAPE in different disorders. The findings elaborate that CAPE is a versatile therapeutically active polyphenol and an effective adjuvant of chemotherapy for enhancing therapeutic efficacy and diminishing chemotherapy-induced toxicities.

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“…Electrospinning is a straightforward and efficient method to fabricate nonwoven mats with continuous fibers in the range from micrometer down to nanometer. Nowadays, nanofibers produced by electrospinning have received the considerably high attention to be an excellent candidate for many important applications in medical field such as drug delivery [1], oral cavity [2], tissue engineering [3][4][5][6], wound dressing and healing [7,8] due to the ultra-fine diameter, high surface area to volume ratio, and cost-effectiveness. A large number of studies devoted to utilizing nanofibers that could mimic the extracellular matrix (ECM) of the body and cellular activity [9], as well as sustained drug action such as in skin regeneration or healing [1,10,11] have been published over the last few years.…”

Section: Introductionmentioning

confidence: 99%

Natural Antibacterial Reagents (Centella, Propolis, and Hinokitiol) Loaded into Poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] Composite Nanofibers for Biomedical Applications

2019

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Centella asiatica, propolis, and hinokitiol, as natural antibacterial reagents, were integrated into the poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] (PHBH) polymer to produce antibacterial wound dressings, using electrospinning process. The results showed that the fiber diameters and surface morphology of PHBH composite nanofibers were influenced by the addition of ethanol–centella (EC), methanol–centella (MC), ethanol–propolis (EP), and ethanol–hinokitiol (EH) at various ratios compared to pristine PHBH nanofibers. From FT-IR, the nanofibrous samples with higher contents of natural antibacterial substances showed the peaks of carboxylic acid, aromatic ring, and tropolone carbon ring from centella, propolis, and hinokitiol, respectively. Furthermore, the tensile strength of neat PHBH nanofibers was increased from 8.00 ± 0.71 MPa up to 16.35 ± 1.78 MPa by loading of propolis (EP) 7% into PHBH. X-ray analysis explained that the loading of propolis (EP) was also able to increase the crystallinity in PHBH composite nanofibers from 47.0% to 54.5%. The antibacterial results demonstrated that PHBH composite nanofibers containing natural antibacterial products were potent inhibitors against the growth of Escherichia coli and Staphylococcus aureus, amongst them hinokitiol and propolis proved to be the most effective. Additionally, the release studies displayed that centella and hinokitiol had faster release from PHBH composite nanofibers in comparison to propolis.

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Antimicrobial medical sutures with caffeic acid phenethyl ester and their in vitro/in vivo biological assessment

Cited by 21 publications

References 37 publications

Suture materials — Current and emerging trends

Suture materials — Current and emerging trends

Caffeic Acid Phenethyl Ester and Therapeutic Potentials

Natural Antibacterial Reagents (Centella, Propolis, and Hinokitiol) Loaded into Poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] Composite Nanofibers for Biomedical Applications

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