Antimicrobial peptide-based materials: opportunities and challenges

Rai, Akhilesh; Ferrão, Rafaela; Palma, Paulo J.; Patrício, Tatiana; Parreira, Paula; Anes, Elsa; Tonda‐Turo, Chiara; Martins, Cristina Araújo; Alves, Nuno; Ferreira, Lino

doi:10.1039/d1tb02617h

Cited by 76 publications

(46 citation statements)

References 350 publications

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“…Polymeric nanoparticles are one of the popular formulations in the size range of 50 to 100 nm, such as chitosan, dextran, polyethylene glycol (PEG), and poly(lactide-co-glycolic acid) (PLGA). Polymeric nanostructures containing AMPs have advantages to increase their stability and consequently improve their antimicrobial performance [ 80 ]. Almaaytah et al, encapsulated a potent ultrashort AMP named RBRBR in chitosan-based nanoparticles (CS-NPs), resulting in potent antimicrobial effects against MDR and biofilm-forming bacteria with negligible systemic toxicity and reduced synthetic costs [ 81 ].…”

Section: Nanodelivery Systemmentioning

confidence: 99%

“…Inorganic materials, such as carbon nanotubes and magnetic nanoparticles, and organic materials, such as cyclodextrin and tetrahedral framework nucleic acid, can be adopted for improving the characteristics of AMPs and gaining the effect of targeting and controlled drug release. Recently, nano-fibers and nano-tapes have been effectively applied to AMPs as well [ 80 , 86 ].…”

Section: Nanodelivery Systemmentioning

confidence: 99%

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Engineering Approaches for the Development of Antimicrobial Peptide-Based Antibiotics

2022

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Antimicrobial peptides (AMPs) have received increasing attention as potential alternatives for future antibiotics because of the rise of multidrug-resistant (MDR) bacteria. AMPs are small cationic peptides with broad-spectrum antibiotic activities and different action mechanisms to those of traditional antibiotics. Despite the desirable advantages of developing peptide-based antimicrobial agents, the clinical applications of AMPs are still limited because of their enzymatic degradation, toxicity, and selectivity. In this review, structural modifications, such as amino acid substitution, stapling, cyclization of peptides, and hybrid AMPs with conventional antibiotics or other peptides, will be presented. Additionally, nanodelivery systems using metals or lipids to deliver AMPs will be discussed based on the structural properties and action mechanisms of AMPs.

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Section: Nanodelivery Systemmentioning

confidence: 99%

Section: Nanodelivery Systemmentioning

confidence: 99%

Engineering Approaches for the Development of Antimicrobial Peptide-Based Antibiotics

2022

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“…However, there are still disadvantages, such as uneven drug release and short life cycles ( Li et al, 2021 ). In addition, in order to solve the problem of bacterial resistance, many novel antibacterial substances, including antimicrobial peptides ( Rai et al, 2022 ), bacteriophages ( Kim et al, 2021 ), and nanoparticles ( Nag et al, 2021 ), have been developed for the loading of drug delivery systems. Recently, the design of implants with antibacterial properties has begun to attract researchers’ attention.…”

Section: The Main Pathogens and Prevention Strategies Of Implant-asso...mentioning

confidence: 99%

Mg-, Zn-, and Fe-Based Alloys With Antibacterial Properties as Orthopedic Implant Materials

Wang

Shi

et al. 2022

Front. Bioeng. Biotechnol.

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Implant-associated infection (IAI) is one of the major challenges in orthopedic surgery. The development of implants with inherent antibacterial properties is an effective strategy to resolve this issue. In recent years, biodegradable alloy materials have received considerable attention because of their superior comprehensive performance in the field of orthopedic implants. Studies on biodegradable alloy orthopedic implants with antibacterial properties have gradually increased. This review summarizes the recent advances in biodegradable magnesium- (Mg-), iron- (Fe-), and zinc- (Zn-) based alloys with antibacterial properties as orthopedic implant materials. The antibacterial mechanisms of these alloy materials are also outlined, thus providing more basis and insights on the design and application of biodegradable alloys with antibacterial properties as orthopedic implants.

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“…In the last few years, antimicrobial peptides (AMPs) have been used as potential therapeutic agents to fight bacteria and promote skin regeneration . The AMP LL37 peptide, belonging to the cathelicidin family, is an endogenous peptide found in human skin, having antimicrobial, angiogenic, and immunomodulatory properties .…”

Section: Introductionmentioning

confidence: 99%

“…In the last few years, antimicrobial peptides (AMPs) have been used as potential therapeutic agents to fight bacteria and promote skin regeneration. 5 The AMP LL37 peptide, belonging to the cathelicidin family, is an endogenous peptide found in human skin, 6 immunomodulatory properties. 7 LL37 peptides interact with surface receptors such as the epidermal growth factor receptor (EGFR) and formyl peptide receptor like-1 (FPRL1) of keratinocytes and endothelial cells, respectively, to mediate the migration of these cells to facilitate the closure of wounds.…”

Section: ■ Introductionmentioning

confidence: 99%

Antimicrobial Peptide-Tether Dressing Able to Enhance Wound Healing by Tissue Contact

Rai

Ferrão

Marta

et al. 2022

ACS Appl. Mater. Interfaces

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No effective therapeutic dressings are currently available in the market that can prevent bacterial infection and simultaneously promote skin regeneration in diabetic patients. The lack of re-epithelization, prevalence of inflammation, and high risk of infection are hallmarks of non-healing wounds. Here, we have evaluated the antimicrobial and pro-regenerative effect of a relatively non-leaching LL37 peptide immobilized in polyurethane (PU)-based wound dressings (PU-adhesive-LL37 dressing). The PU-adhesive-LL37 (63 μg LL37NPs/cm 2 ) dressing killed Grampositive and Gram-negative bacteria in human serum without inducing bacterial resistance after 16 antimicrobial test cycles in contrast to commercially available dressings with the capacity to release antimicrobial Ag ions. Importantly, type II diabetic mice (db/db mice) treated with the PU-adhesive-LL37 dressing for different periods of time (6 or 14 days) showed enhanced wound healing and re-epithelialization (i.e., high keratin 14/5 levels) and lower macrophage infiltration in the wounds compared to animals treated with PU. The wounds treated with PU-adhesive-LL37 dressings showed also low expression of pro-inflammatory cytokines such as TNF-α and IL6 after 6 days of treatment, indicating that they act as an anti-inflammatory dressing. Additionally, PUadhesive-LL37 dressings do not induce acute inflammatory responses in the peripheral blood mononuclear cells (PBMCs) after 3 days of exposure, in contrast to controls. Taken together, PU-adhesive-LL37NP dressings might prevent the bacterial infections and facilitate wound healing by tissue contact, inducing re-epithelialization and anti-inflammatory processes in diabetic conditions.

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Antimicrobial peptide-based materials: opportunities and challenges

Abstract: The multifunctional properties of antimicrobial peptides (AMPs) make them attractive candidates for the treatment of various diseases. AMPs are considered alternatives to antibiotics due to the rising number of multidrug-resistant...

Cited by 76 publications

References 350 publications

Engineering Approaches for the Development of Antimicrobial Peptide-Based Antibiotics

Engineering Approaches for the Development of Antimicrobial Peptide-Based Antibiotics

Mg-, Zn-, and Fe-Based Alloys With Antibacterial Properties as Orthopedic Implant Materials

Antimicrobial Peptide-Tether Dressing Able to Enhance Wound Healing by Tissue Contact

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