2019
DOI: 10.1007/s10989-019-09946-9
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Antimicrobial Peptides (AMPs): Roles, Functions and Mechanism of Action

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Cited by 134 publications
(91 citation statements)
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“…Subsequently, the bacterial membrane is disrupted, leading to insertion of antimicrobial peptides into the membranes and, often, the formation of pores [ 33 ]. Various mechanisms have been suggested for the permeation of antimicrobial peptides through bacterial membranes and have been extensively reviewed [ 38 , 39 ]. In summary, antimicrobial peptide binding leads to a breakdown of membrane potential, an alteration in membrane permeability, and metabolite leakage, ultimately causing bacterial cell death.…”
Section: Antimicrobial Peptides In Naturementioning
confidence: 99%
“…Subsequently, the bacterial membrane is disrupted, leading to insertion of antimicrobial peptides into the membranes and, often, the formation of pores [ 33 ]. Various mechanisms have been suggested for the permeation of antimicrobial peptides through bacterial membranes and have been extensively reviewed [ 38 , 39 ]. In summary, antimicrobial peptide binding leads to a breakdown of membrane potential, an alteration in membrane permeability, and metabolite leakage, ultimately causing bacterial cell death.…”
Section: Antimicrobial Peptides In Naturementioning
confidence: 99%
“…The electrostatic interaction between the negatively charged phospholipids of the bacterial membrane and positively charged peptides is an important requirement in the mechanism of action of AMPs (Seyfi et al, 2019 In the barrel-stave model, AMPs initially bind to the membrane as a monomer, may undergo a conformational transition, and induce localized membrane thinning. After the threshold concentration is reached, the monomers oligomerize and become further inserted into the hydrophobic core of the membrane (Avci, Akbulut, & Ozkirimli, 2018;Ciumac, Gong, Hu, & Lu, 2019).…”
Section: Mechanisms Of Actionmentioning
confidence: 99%
“…The electrostatic interaction between the negatively charged phospholipids of the bacterial membrane and positively charged peptides is an important requirement in the mechanism of action of AMPs (Seyfi et al, 2019). The net negative charge is responsible for the initial adsorption of AMPs in the bacterial membrane, which is rich in anionic lipids; both gram‐positive and gram‐negative bacteria contain negatively charged membrane phospholipids, in addition, gram‐positive possess teichoic acid and gram‐negative have lipopolysaccharides (LPS), which are negatively charged substances (Feijó‐Corrêa, Gonçalves Evangelista, de Melo Nazareth, & Bittencourt Luciano, 2019).…”
Section: Mechanisms Of Actionmentioning
confidence: 99%
“…Antimicrobial peptides are a crucial component of the innate immune response and have a broad and diverse antibacterial, antifungal, antiviral, and even anticancer activity [ 132 ]. They are considered to be potent and highly-promising therapeutic agents because of the benefits that they provide over currently used antibiotics [ 133 ].…”
Section: The Role Of Proteomic Analysis In Generating New Insight mentioning
confidence: 99%