Antimicrobial Peptides and their Potential as Therapeutants in Aquaculture

Effects of antimicrobial peptides on growth, feed utilization, serum biochemical indices and disease resistance of juvenile shrimp,Litopenaeus vannamei

“…One of the major threats facing the shrimp aquaculture industry is infectious diseases caused by bacteria and fungi because they live in an environment that is exposed to pollution (Douglas, ). In other to observe the effects of AMP on disease resistance in shrimp, Vibrio harveyi was used as a bacterial challenge test in shrimp.…”

“…In other to observe the effects of AMP on disease resistance in shrimp, Vibrio harveyi was used as a bacterial challenge test in shrimp. With the multifunctional immunity, AMP can be used to improve the nonspecific immune response of shrimp against pathogens as well as kill pathogens (Douglas, ). The essential relationship of AMP in its chemical structure, which is cationic and anionic features and high specificity to bacteria cells, is mainly vital to its cytotoxicity for bacteria.…”

“…Also, numerous Penaeidins have been produced in yeast (Destoumieux, Bulet, Strub, Dorsselaer, & Bachère, ; Li et al, ) proposing an evolutionary deep‐rooted role in immunity. Antimicrobial peptides AMPs with therapeutic possibilities have been in focus in recent times (Douglas, ; Jia et al, ). It is notable that the increase in bacterial resistance to these peptides is rare and readily advanced likened to conventional antibiotics (Cabello, ; Noga et al, ; Steinberg et al, ).…”

Antimicrobial peptide CAP18 and its effect on Yersinia ruckeri infections in rainbow trout Oncorhynchus mykiss (Walbaum): comparing administration by injection and oral routes

“…As these peptides are vulnerable to proteolytic degradation in the gut environment, it may be suggested that the orally administered CAP18 was degraded following ingestion. Therefore, for future studies it may be suggested to improve stability and protease resistance of this peptide by adding compounds such as chitosan or alginate to the feed (Hancock & Sahl ; Douglas ). In addition, although vacuum and oil coating was used for optimizing AMP adhesion to feed pellets, it cannot be excluded that part of the CAP18 leached from the feed following feeding.…”

“…This has raised growing concern for future control of fish diseases and new and alternative antimicrobial peptides with a therapeutic potential have therefore been in focus (Jia et al . ; Douglas ). It is noteworthy that development of bacterial resistance to these peptides is less readily developed compared to conventional antibiotics (Steinberg et al .…”