Antimicrobial Photodynamic Therapy in the Treatment of Chronic Adult Periodontitis

Abstract

Objective: Antimicrobial photodynamic therapy (aPDT) is a new adjunctive therapy for chronic periodontitis. The study hypothesis was that aPDT applied as an adjunct to scaling and root planing (SRP) would improve 12-week clinical outcomes in the treatment of chronic adult periodontitis, compared to SRP alone.Methods: 34 patients diagnosed with chronic periodontitis were recruited into a randomized, examiner-blinded, parallel-group study with two equal cohorts (SRP alone and SRP + aPDT). Both cohorts were treated with SRP at all probing sites ≥ 5 mm that exhibited bleeding on probing (BOP). In the intervention group a single aPDT treatment was deployed following SRP.Results: Combination therapy (aPDT + SRP) produced significant gain in clinical attachment level (CAL) (0.53 mm, p=0.0017) and probing depth reductions (PD) (0.73 mm, p=0.0002) when averaged across all regions of the mouth, versus the SRP-only arm at 3 months. Treatment with adjunctive aPDT increased by 8-fold the number of patients experiencing >1.5 mm gain in CAL, versus the control arm (5.9% in the SRP arm, 47.1% in the aPDT arm, p=0.022) at 3 months. Conclusions:This study demonstrated that adjunctive aPDT provided significant gain in CAL and PD reduction, compared to SRP alone in the treatment of chronic adult periodontitis.

Comparison between Antimicrobial Photodynamic Therapy and Injectable Platelet Rich Fibrin as an adjunct to Non-Surgical Periodontal Treatment (A Randomized Controlled Clinical Trial with Microbiological Assessment)

“…Studies have shown that biofilms of oral bacteria are much more difficult to eradicate by conventional means because of the strong tissue adherence and physical exclusion of antimicrobial substances in biofilms. The fact that a-PDT was found to be so effective against biofilms and this suggests an advantage over other antimicrobial periodontal therapies (8) .…”

Near-Infrared Light-Activated DNA-Agonist Nanodevice for Nongenetically and Remotely Controlled Cellular Signaling and Behaviors in Live Animals

“…Next, we assessed the potential applications of the NIR-DA system in the optical control of MET signaling and cellular behaviors in animals. We chose to assess this in the setting of skeletal muscle regeneration in mice [38][39][40] , which requires penetrating capacities of NIR light-activation to act on muscle tissues that are under the thick skin. During injury-initiated skeletal muscle regeneration, the muscle precursor myogenic cells migrate to and differentiate at the site of injury to regenerate into functional myocytes within skeletal muscles.…”