Antimicrobial photodynamic therapy with hypocrellin B against SARS-CoV-2 infection?

Law, Siukan; Lo, Chuiman; Han, Jie; Leung, Albert Wingnang; Xu, Chuanshan

doi:10.1016/j.pdpdt.2021.102297

Cited by 5 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HB exhibited negligible dark toxicity and efficiently deactivated C. albicans cells in a light-dose and PS concentration-dependent manner (59). Recently, Law et al proposed HB as a potential PS for PDT in the treatment of SARS-CoV-2 (94). These innovative approaches hold great potential for enhancing therapeutic outcomes in the treatment of microbial infections.…”

Section: Hypocrellinsmentioning

confidence: 99%

Polyphenolic natural products as photosensitizers for antimicrobial photodynamic therapy: recent advances and future prospects

Wang,

Fekrazad

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Antimicrobial photodynamic therapy (aPDT) has become a potent contender in the fight against microbial infections, especially in the context of the rising antibiotic resistance crisis. Recently, there has been significant interest in polyphenolic natural products as potential photosensitizers (PSs) in aPDT, given their unique chemical structures and inherent antimicrobial properties. Polyphenolic natural products, abundant and readily obtainable from natural sources, are generally regarded as safe and highly compatible with the human body. This comprehensive review focuses on the latest developments and future implications of using natural polyphenols as PSs in aPDT. Paramount polyphenolic compounds, including curcumin, hypericin, quercetin, hypocrellin, celastrol, riboflavin, resveratrol, gallic acid, and aloe emodin, are elaborated upon with respect to their structural characteristics, absorption properties, and antimicrobial effects. Furthermore, the aPDT mechanism, specifically its targeted action on microbial cells and biofilms, is also discussed. Polyphenolic natural products demonstrate immense potential as PSs in aPDT, representing a promising alternate approach to counteract antibiotic-resistant bacteria and biofilm-related infections.

show abstract

Section: Hypocrellinsmentioning

confidence: 99%

Polyphenolic natural products as photosensitizers for antimicrobial photodynamic therapy: recent advances and future prospects

Wang,

Fekrazad

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…60 Hypocrellins, mainly HB, are monomeric perylenequinone pigments derived from the traditional Chinese herbal medicine H. bambuase, which was widely used as a photosensitizer for PDT against cancer and infectious diseases. 89 Wang et al found that HB-mediated SDT reduced the CFU of MRSA by 5-log compared to the control group. Flow cytometry analysis revealed that impairment of membrane integrity might be a major cause of MRSA death.…”

Section: Organic Sonosensitizersmentioning

confidence: 99%