Antimicrobial PLGA ultrafine fibers: Interaction with wound bacteria

Said, Somiraa S.; Al-Oufy, Affaf; El-Halfawy, Omar M.; Boraei, Nabila A.; El-Khordagui, Labiba K.

doi:10.1016/j.ejpb.2011.03.002

Cited by 96 publications

(36 citation statements)

References 46 publications

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“…Yet, after 24 h the CFU dropped significantly. To our best knowledge the antimicrobial properties of PLGA have been studied only as a reference to scaffolds containing drugs [49,50]. Unfortunately, in both cases, a different L/G ratio and combinations with other polymers do not allow a direct comparison to be drawn to our results.…”

Section: Bacteria Culture and Viabilitymentioning

confidence: 74%

pH-dependent antibacterial effects on oral microorganisms through pure PLGA implants and composites with nanosized bioactive glass

et al. 2013

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Biomaterials made of biodegradable poly(-hydroxyesters) such as poly(lactide-co-glycolide) (PLGA) are known to decrease the pH in the vicinity of the implants. Bioactive glass (BG) is being investigated as a counteracting agent buffering the acidic degradation products. However, in dentistry the question arises whether an antibacterial effect is rather obtained from pure PLGA or from BG/PLGA composites, as BG has been proved to be antimicrobial. In the present study the antimicrobial properties of electrospun PLGA and BG45S5/PLGA fibres were investigated using human oral bacteria (specified with mass spectrometry) incubated for up to 24 h. BG45S5 nanoparticles were prepared by flame spray synthesis. The change in colony-forming units (CFU) of the bacteria was correlated with the pH of the medium during incubation. The morphology and structure of the scaffolds as well as the appearance of the bacteria were followed bymicroscopy. Additionally, we studied if the presence of BG45S5 had an influence on the degradation speed of the polymer. Finally, it turned out that the pH increase induced by the presence of BG45S5 in the scaffold did not last long enough to show a reduction in CFU. On the contrary, pure PLGA demonstrated antibacterial properties that should be taken into consideration when designing biomaterials for dental applications. AbstractBiomaterials made of biodegradable poly(α-hydroxyesters) like poly(lactide-co-glycolide) (PLGA) are known to decrease the pH in the vicinity of the implants. Bioactive glass (BG) is being investigated as a counteracting agent buffering the acidic degradation products.However, in dentistry the question arises whether an antibacterial effect is rather obtained from pure PLGA or from BG/PLGA composites, as BG has been proved antimicrobial. In the present study the antimicrobial properties of electrospun PLGA and BG45S5/PLGA fibres were investigated using human oral bacteria (specified with mass spectrometry) incubated for up to 24 h. BG45S5 nanoparticles were prepared by flame spray synthesis. The change in colony-forming units (CFU) of the bacteria was put into correlation with the pH of the medium during incubation. Morphology and structure of the scaffolds as well as the appearance of the bacteria were followed by microscopy. Additionally, we studied if the presence of BG45S5 had an influence on the degradation speed of the polymer. Finally, it turned out that the pH increase induced by BG45S5 presence in the scaffold did not last long enough to show a reduction in CFU. On the contrary, pure PLGA demonstrated antibacterial properties that should be taken into consideration when designing biomaterials for dental applications.

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Section: Bacteria Culture and Viabilitymentioning

confidence: 74%

pH-dependent antibacterial effects on oral microorganisms through pure PLGA implants and composites with nanosized bioactive glass

et al. 2013

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“…40 The calculated kinetic release parameters are show in Table III. The largest r 2 values were obtained for the Higuchi equations.…”

Section: Drug Release Studymentioning

confidence: 99%

Fabrication and Characterization of Poly(lactic acid)/Poly(<I>ε</I>-caprolactone) Blend Electrospun Fibers Loaded with Amoxicillin for Tunable Delivering

Valarezo¹,

Tammaro²,

Malagón³

et al. 2015

j nanosci nanotechnol

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Blends of poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL), loaded with different amounts of Amoxicillin antibiotic (AMOX) were electrospun to investigate their release properties and obtain a controlled and tuneable release. The processing parameters for electrospinning were set up and reliable membranes were obtained. Morphology and thermal behaviour were found dependent on the component ratio as well as on the incorporated drug amount. A very different release kinetics of the two pristine polymers, very rapid for PCL and very slow for PLA, reflected in intermediate release time. However comparing the release amount with that predicted by the mixture rule a preferential incorporation of AMOX into PLA can be inferred.

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“…However, loading of adequate concentrations of fusidic acid into the nanofibers remarkably prohibited bacterial biofilm formation. 90 The ability of epidermal GF (EGF)-loaded silk nanofibers was also demonstrated to contribute strongly towards the healing process by decreasing the time of wound closure. 91 A transdermal drug-delivery system (TDDS) is designed to support and facilitate the delivery of target agents into the body through the skin.…”

Section: Transdermal Systems and Wound Dressingsmentioning

confidence: 99%

Advances in drug delivery via electrospun and electrosprayed nanomaterials

Zamani¹,

Prabhakaran²,

Ramakrishna³

2013

IJN

204

104

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Electrohydrodynamic (EHD) techniques refer to procedures that utilize electrostatic forces to fabricate fibers or particles of different shapes with sizes in the nano-range to a few microns through electrically charged fluid jet. Employing different techniques, such as blending, surface modification, and coaxial process, there is a great possibility of incorporating bioactive such molecules as drugs, DNA, and growth factors into the nanostructures fabricated via EHD techniques. By careful selection of materials and processing conditions, desired encapsulation efficiency as well as preserved bioactivity of the therapeutic agents can be achieved. The drug-loaded nanostructures produced can be applied via different routes, such as implantation, injection, and topical or oral administration for a wide range of disease treatment. Taking advantage of the recent developments in EHD techniques like the coaxial process or multilayered structures, individually controlled delivery of multiple drugs is achievable, which is of great demand in cancer therapy and growth-factor delivery. This review summarizes the most recent techniques and postmodification methods to fabricate electrospun nanofibers and electrosprayed particles for drug-delivery applications.

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Antimicrobial PLGA ultrafine fibers: Interaction with wound bacteria

Cited by 96 publications

References 46 publications

pH-dependent antibacterial effects on oral microorganisms through pure PLGA implants and composites with nanosized bioactive glass

pH-dependent antibacterial effects on oral microorganisms through pure PLGA implants and composites with nanosized bioactive glass

Fabrication and Characterization of Poly(lactic acid)/Poly(<I>ε</I>-caprolactone) Blend Electrospun Fibers Loaded with Amoxicillin for Tunable Delivering

Advances in drug delivery via electrospun and electrosprayed nanomaterials

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