Antimicrobial potential of bismuth lipophilic nanoparticles embedded into chitosan-based membrane

Martínez-Martínez, Marco Antonio; Hernandez-Delgadillo, Rene; Abada, Bilal; Pineda‐Aguilar, Nayely; Solís-Soto, Juan Manuel; Nakagoshi-Cepeda, María Argelia Akemi; Nakagoshi-Cepeda, Sergio Eduardo; Chellam, Shankararaman; Sánchez-Najera, Rosa Isela; Cabral-Romero, Claudio

doi:10.4012/dmj.2018-173

Cited by 5 publications

(2 citation statements)

References 42 publications

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“…14 We have previously reported the efficacy of bismuth lipophilic nanoparticles (BisBAL NPs) against several oral pathogens, including E. faecalis . 15 We have also demonstrated that the cement mineral trioxide aggregate (MTA) supplemented with BisBAL NPs acquired antimicrobial and antibiofilm activities against E. faecalis . 16 As a continuation of this work, here we report the antimicrobial potential of AH Plus BisBAL NPs against E. faecalis , both a commercial strain and clinical isolates from patients with endodontic infection.…”

Section: Introductionmentioning

confidence: 93%

“…Bis-BAL NPs were synthesized and analyzed as previously reported. [15][16][17] Briefly, bismuth nitrate in propylene glycol (Bis) was mixed 2:1 with 2,3-dimercapto-1-propanol (BAL) to produce BisBAL nanostructures. The distributions of BisBAL NP size and shape were analyzed with scanning electron microscopy (SEM; FEI Tecnai G2 Twin, Hillsboro, OR; 160 kV accelerating voltage).…”

Section: Materials Development and Characterizationmentioning

confidence: 99%

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Antimicrobial potential of AH Plus supplemented with bismuth lipophilic nanoparticles on E. faecalis isolated from clinical isolates

Torres-Betancourt

Hernandez-Delgadillo

Flores-Treviño

et al. 2022

Journal of Applied Biomaterials & Functional Materials

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The objective of this study was to determine the antimicrobial potential of AH plus supplemented with bismuth lipophilic nanoparticles (BisBAL NPs) on the growth of Enterococcus faecalis isolated from patients with endodontic infections. BisBAL NPs, synthesized with the colloidal method, were characterized, in its pure form or AH Plus-absorbed, by energy-dispersive X-ray spectroscopy and scanning electron microscopy (EDS-SEM). Antimicrobial activity was evaluated with disc diffusion assays, and antibiofilm activity with fluorescence microscopy. BisBAL NP-supplemented AH Plus had a 4.9 times higher antimicrobial activity than AH Plus alone ( p = 0.0001). In contrast to AH Plus alone, AH Plus supplemented with BisBAL NP inhibited E. faecalis biofilm formation. The sealing properties of AH plus were not modified by the incorporation of BisBAL NPs, which was demonstrated by a 12-day split-chamber leakage assay with daily inoculation, which was used to evaluate the possible filtration of E. faecalis. Finally, BisBAL NP-supplemented AH plus-BisBAL NPs was not cytotoxic for cultured human gingival fibroblasts. Their viability was 83.7% to 89.9% after a 24-h exposure to AH Plus containing 50 and 10 µM BisBAL NP, respectively. In conclusion, BisBAL NP-supplemented AH Plus constitutes an innovative nanomaterial to prevent re-infection in endodontic patients without cytotoxic effects.

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Section: Introductionmentioning

confidence: 93%

Section: Materials Development and Characterizationmentioning

confidence: 99%

Antimicrobial potential of AH Plus supplemented with bismuth lipophilic nanoparticles on E. faecalis isolated from clinical isolates

Torres-Betancourt

Hernandez-Delgadillo

Flores-Treviño

et al. 2022

Journal of Applied Biomaterials & Functional Materials

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Investigation of biological accumulation and eco-genotoxicity of bismuth oxide nanoparticle in fresh water snail Lymnaea luteola

Al-Abdan

Bin-Jumah

Ali

et al. 2021

Journal of King Saud University - Science

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The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

et al. 2020

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Studies of nanosized forms of bismuth (Bi)-containing materials have recently expanded from optical, chemical, electronic, and engineering fields towards biomedicine, as a result of their safety, cost-effective fabrication processes, large surface area, high stability, and high versatility in terms of shape, size, and porosity. Bi, as a nontoxic and inexpensive diamagnetic heavy metal, has been used for the fabrication of various nanoparticles (NPs) with unique structural, physicochemical, and compositional features to combine various properties, such as a favourably high X-ray attenuation coefficient and near-infrared (NIR) absorbance, excellent light-to-heat conversion efficiency, and a long circulation half-life. These features have rendered bismuth-containing nanoparticles (BiNPs) with desirable performance for combined cancer therapy, photothermal and radiation therapy (RT), multimodal imaging, theranostics, drug delivery, biosensing, and tissue engineering. Bismuth oxyhalides (BiO x , where X is Cl, Br or I) and bismuth chalcogenides, including bismuth oxide, bismuth sulfide, bismuth selenide, and bismuth telluride, have been heavily investigated for therapeutic purposes. The pharmacokinetics of these BiNPs can be easily improved via the facile modification of their surfaces with biocompatible polymers and proteins, resulting in enhanced colloidal stability, extended blood circulation, and reduced toxicity. Desirable antibacterial effects, bone regeneration potential, and tumor growth suppression under NIR laser radiation are the main biomedical research areas involving BiNPs that have opened up a new paradigm for their future clinical translation. This review emphasizes the synthesis and state-of-the-art progress related to the biomedical applications of BiNPs with different structures, sizes, and compositions. Furthermore, a comprehensive discussion focusing on challenges and future opportunities is presented.

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Antimicrobial potential of bismuth lipophilic nanoparticles embedded into chitosan-based membrane

Cited by 5 publications

References 42 publications

Antimicrobial potential of AH Plus supplemented with bismuth lipophilic nanoparticles on E. faecalis isolated from clinical isolates

Antimicrobial potential of AH Plus supplemented with bismuth lipophilic nanoparticles on E. faecalis isolated from clinical isolates

Investigation of biological accumulation and eco-genotoxicity of bismuth oxide nanoparticle in fresh water snail Lymnaea luteola

The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

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