Antimicrobial potentials of endophytic fungi residing in Quercus variabilis and brefeldin A obtained from Cladosporium sp.

Wang, F. W.; Jiao, Rui‐Hua; Cheng, An; Tan, Shu Hua; Song, Yong

doi:10.1007/s11274-006-9195-4

Cited by 149 publications

(80 citation statements)

References 17 publications

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“…Why can these latent pathogens live in plant tissues without apparent symptoms? One reason may be that endophytes produce antibiotic substances (Wang et al, 2007). Because of the increasing evidence that endophytes have apparent resistance to plant pathogens, endophytes are gaining attention as subjects for research and applications in Plant Pathology.…”

Section: Discussionmentioning

confidence: 99%

A cultured endophyte community is associated with the plant Clerodendrum inerme and antifungal activity

Gong¹,

Xh²,

Yq³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Fungal endophytes live in the inner tissues of Clerodendrum inerme and may be significant resources for new chemicals in drug discovery. A total of 242 endophytic fungi were recovered from 602 sample segments of C. inerme; 66 were purified. The 66 fungi belonging to 16 taxa and 11 genera (Alternaria, Nigrospora, Bartalinia, Pestalotiopsis, Fusarium, Mycoleptodiscus, Trichoderma, Phomopsis, Diaporthe, Lasiodiplodia, and Curvularia) were identified by morphological characteristics and fungal internal transcribed spacer sequences. The most abundant genera were Alternaria and Lasiodiplodia. Some of the endophytes exhibited tissue specificity. The colonization frequencies of endophytes in the stems were evidently higher than those in the roots and leaves. The crude ethyl acetate extracts were tested against 6 endophytes isolated from C. inerme. Three of 10 (33.3%) endophytes, which were identified as Phomopsis sp, Curvularia sp, and Mycoleptodiscus sp, displayed distinct antifungal activity against ≥3 tested fungi. To our knowledge, this is the first report of an endophytic community associated with C. inerme in China and its antifungal activity in vitro.

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Section: Discussionmentioning

confidence: 99%

A cultured endophyte community is associated with the plant Clerodendrum inerme and antifungal activity

Gong¹,

Xh²,

Yq³

et al. 2015

Genet. Mol. Res.

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“…Many endophytic species produce antibiotic substances (Strobel, 2002;Schulz and Boyle, 2005;Wang et al, 2007). Liquid extracts from endophyte cultures have been found to inhibit the growth of several species of plant pathogenic fungi (Liu et al, 2001;Park et al, 2005;Inácio et al, 2006;Kim et al, 2007).…”

Section: Interactions With Plant Pathogenic Fungimentioning

confidence: 99%

Fungal endophytes and their interaction with plant pathogens: a review

Zabalgogeazcoa

2008

Span. j. agric. res.

136

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Endophytes are fungi which infect plants without causing symptoms. Fungi belonging to this group are ubiquitous, and plant species not associated to fungal endophytes are not known. In addition, there is a large biological diversity among endophytes, and it is not rare for some plant species to be hosts of more than one hundred different endophytic species. Different mechanisms of transmission, as well as symbiotic lifestyles occur among endophytic species. Latent pathogens seem to represent a relatively small proportion of endophytic assemblages, also composed by latent saprophytes and mutualistic species. Some endophytes are generalists, being able to infect a wide range of hosts, while others are specialists, limited to one or a few hosts. Endophytes are gaining attention as a subject for research and applications in Plant Pathology. This is because in some cases plants associated to endophytes have shown increased resistance to plant pathogens, particularly fungi and nematodes. Several possible mechanisms by which endophytes may interact with pathogens are discussed in this review.

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“…and Alternaria sp.) showed significant antimicrobial activity (Wang et al, 2007). Phongpaichit et al (2006) isolated 377 fungi and their fermentation broths were tested for antimicrobial activity.…”

Section: Antimicrobial Assaymentioning

confidence: 99%

Biological activities of the fermentation extract of the endophytic fungus Alternaria alternata isolated from Coffea arabica L.

Fernandes

Silva

Pfenning

et al. 2009

Braz. J. Pharm. Sci.

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A total of 22 endophytic fungi isolated from coffee (Coffea arabica L.) were cultivated in vitro and their crude extracts tested. The screening was carried out using the agar diffusion method against Staphylococcus aureus, Escherichia coli and Candida albicans. The most effective isolate was Alternaria alternata, and subsequently, its extract was assayed. The total phenolic content was 3.44 μg GAE/mg of the crude extract. For the antibacterial and antifungal activity assays, minimum inhibitory concentrations (MIC) and minimum bactericidal and fungicidal concentrations (MBC and MFC) were determined. The ranges of MIC values were 50-100 μg/mL for S. aureus and 400-800 μg/mL for E. coli. The extract did not show activity in the tested concentrations for C. albicans. The fungal crude extract was assayed for antioxidant activities. Its ability to scavenge DPPH radicals and antioxidant activity by β-carotene/ linoleic acid system oxidation was not significant. In addition, antitumor activity was studied using the MTT assay. At a dilution of 400 μg/mL, the extract displayed a cytotoxic activity of approximately 50% towards HeLa cells in vitro. The results indicate that endophytic fungi could be a promising source of bioactive compounds and warrant further study.Uniterms: Endophytic fungi. Bioactive compounds. Alternaria alternata/extract/antioxidant activity.Total de 22 fungos endofíticos isolados de café (Coffea arabica L.) foi cultivado in vitro e seus extratos testados. A triagem foi conduzida pelo método de difusão em agar contra bactérias Gram-positiva, Gram-negativa e uma levedura. O isolado mais efetivo foi Alternaria alternata e, subsequentemente, seu extrato foi analisado. O conteúdo de fenólicos totais do extrato bruto foi de 3,44 μg EAG/mg de extrato. Para os testes de atividade antimicrobiana, a concentração inibitória mínima (CIM) e concentração bactericida e fungicida mínima (CBM e CFM) contra Staphylococcus aureus, Escherichia coli e Candida albicans foram determinadas. Resultados da CIM variaram entre 50-100 μg/mL para S. aureus e 400-800 μg/mL para E. coli. O extrato bruto não apresentou atividade nas concentrações testadas para C. albicans. Foram analisadas as atividades antioxidantes do extrato bruto. Sua habilidade para seqüestrar radicais DPPH e a atividade antioxidante pela oxidação do sistema β-caroteno/ácido linoléico não foram significativas. Além disso, a atividade antitumoral foi estudada pelo teste do MTT. À diluição de 400 μg/mL, o extrato apresentou atividade de aproximadamente 50% sobre as células HeLa in vitro. Os resultados indicam que fungos endófitos poderiam ser uma fonte promissora de compostos bioativos necessitando de estudos futuros.Unitermos: Fungos endofíticos. Compostos bioativos. Alternaria alternata/extrato/atividade antioxidante.

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Antimicrobial potentials of endophytic fungi residing in Quercus variabilis and brefeldin A obtained from Cladosporium sp.

Cited by 149 publications

References 17 publications

A cultured endophyte community is associated with the plant Clerodendrum inerme and antifungal activity

A cultured endophyte community is associated with the plant Clerodendrum inerme and antifungal activity

Fungal endophytes and their interaction with plant pathogens: a review

Biological activities of the fermentation extract of the endophytic fungus Alternaria alternata isolated from Coffea arabica L.

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