Antimicrobial properties of graphene-like nanoparticles: coating effect on Staphylococcus aureus

Olivi, Massimiliano; Alfè, Michela; Gargiulo, Valentina; Valle, Francesco; Mura, Francesco; Giosia, Matteo Di; Rapino, Stefania; Palleschi, Claudio; Uccelletti, Daniela; Fiorito, Silvana

doi:10.1007/s11051-016-3673-x

Cited by 41 publications

(18 citation statements)

References 38 publications

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“…Among them is bacterial wrapping: this mechanism characterizes the interaction, for example, of graphene nanoplatelets with bacteria, as shown in Figure 2. The D-nanostructure adheres to the bacterium surface and induces mechanical stress [64][65][66]. Several results report on the important role of 2D basal planes rather than edges in antimicrobial properties, in which completely flat Langmuir-Blodgett films act against bacterial cells having few contacts with sheet edges [67,68].…”

Section: Graphene-based Nanomaterials As Novel Antimicrobial Drugsmentioning

confidence: 99%

Surface Disinfections: Present and Future

Saccucci

Bruni

Uccelletti

et al. 2018

Journal of Nanomaterials

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The propagation of antibiotic resistance increases the chances of major infections for patients during hospitalization and the spread of health related diseases. Therefore finding new and effective solutions to prevent the proliferation of pathogenic microorganisms is critical, in order to protect hospital environment, such as the surfaces of biomedical devices. Modern nanotechnology has proven to be an effective countermeasure to tackle the threat of infections. On this note, recent scientific breakthroughs have demonstrated that antimicrobial nanomaterials are effective in preventing pathogens from developing resistance. Despite the ability to destroy a great deal of bacteria and control the outbreak of infections, nanomaterials present many other advantages. Moreover, it is unlikely for nanomaterials to develop resistance due to their multiple and simultaneous bactericidal mechanisms. In recent years, science has explored more complex antimicrobial coatings and nanomaterials based on graphene have shown great potential in antibacterial treatment. The purpose of this article is to deepen the discussion on the threat of infections related to surface disinfection and to assess the state of the art and potential solutions, with specific focus on disinfection procedures using nanomaterials.

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Section: Graphene-based Nanomaterials As Novel Antimicrobial Drugsmentioning

confidence: 99%

Surface Disinfections: Present and Future

Saccucci

Bruni

Uccelletti

et al. 2018

Journal of Nanomaterials

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“…Two different composite morphologies have been explored and a dependence of the photocatalytic activity has been assessed, revealing an enhanced photocatalytic activity, with respect to the neat TiO 2 , attributed to the broader variety of stable free-radical species generated, at a given photocatalyst morphology, within the delocalized π-electron systems [98]. The antibacterial properties of GL layers also open new possibilities in their exploitation for the fabrication of new biocompatible materials [99].…”

Section: Experimental and Discussionmentioning

confidence: 99%

Graphene-Like Layers from Unconventional Carbon Sources: New Perspectives on Hybrid Materials and π-system Synergisms

Capua

Gargiulo

AlfГЁ

2016

Eurasian Chem. Tech. J.

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We developed a new approach for producing graphene-like (GL) materials through a two-steps oxidation/reduction method starting from a nanostructured (high surface) carbon black, a versatile carbonaceous material prone to be structurally and chemically modified in quite mild wet conditions. Atomic Force Microscopy and zetapotential measurements allowed to model the assembling mechanisms and the role of hydrophobic interactions, demonstrating the possibility to easily tune the surface morphology. GL materials have been then employed in a large variety of hybrid materials for innovative applications, and characterized by chemical, electrical, structural and spectroscopic techniques. With Metal-Organic Frameworks, GL produced conducting composites with electrical conductivity tunable by changing the concentration of the parent materials; Eumelanin/GL and TiO 2 -nanoparticles/GL were also studied for photocatalysis and biosensors applications.

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“…The imaging survey by FE-SEM and AFM microscopies revealed the instauration of an intimate contact between the cells and the GL layers: cells appeared almost covered by the nanomaterial and no mechanical damage of the bacteria was observed confirming the preservation and the integrity of the plasma membrane. These experimental evidences suggested that the GL antimicrobical properties were based mainly on the interaction between GL layers and bacteria surfaces [32], then acting as bacteriostatic agent more than cells toxic agent. Fig.…”

Section: Graphene-like (Gl) Layers and Ultrathin (Gl) Films [24-27]mentioning

confidence: 97%

“…Thanks to their peculiar characteristics, GL layers are also particularly suitable to homogenously coat non-planar surfaces, including particles (TiO 2 , Silica, Al 2 O 3 ) and living cells [32]. The interest in contacting living cells with graphene and GRMs relies in their proven potential antimicrobial and scavenging activities.…”

Section: Graphene-like (Gl) Layers and Ultrathin (Gl) Films [24-27]mentioning

confidence: 99%

“…The interest in contacting living cells with graphene and GRMs relies in their proven potential antimicrobial and scavenging activities. GL layers have been found to act as inhibitor toward the planktonic growth of S.aureus cells also hindering the formation of S.aureus biofilms [32]. The presence of GL in the of S.aureus cells culture media induces a severe decrease of colony forming units (CFU).…”

Section: Graphene-like (Gl) Layers and Ultrathin (Gl) Films [24-27]mentioning

confidence: 99%

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An Old but Lively Nanomaterial: Exploiting Carbon Black for the Synthesis of Advanced Materials

Alfè

Gargiulo

Capua

2019

Eurasian Chem. Tech. J.

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Carbon black (CB) is an old-concept but versatile carbonaceous material prone to be structurally and chemically modified under quite mild wet conditions. Recently, we exploited the potentiality of CB for the production of a highly varied array of advanced materials with applications in energetics, water remediation and sensoristic. The proposed approaches are devised to meet specific needs: low production costs, scalable synthetic approaches, flexibility i.e. easy tuning of chemico-physical properties of the carbon-based advanced materials. Two main approaches have been exploited: modification of CB at the surface and highly CB de-structuration. The former approach allows obtaining highly homogenous CB-modified nanoparticles (around 160 nm) with tunable surface properties (hydrophilicity, typology of functional groups and surface charge density, pore size distribution), supports for ionic liquid (SILP) and composites (carbon-iron oxide). The latter approach exploiting a top-down demolition of CB produces a highly versatile graphene related material (GRM), made up by stacked short graphene-like layers (GL) particularly suitable for advanced composites synthesis and ultrathin carbon-based films production.

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Antimicrobial properties of graphene-like nanoparticles: coating effect on Staphylococcus aureus

Cited by 41 publications

References 38 publications

Surface Disinfections: Present and Future

Surface Disinfections: Present and Future

Graphene-Like Layers from Unconventional Carbon Sources: New Perspectives on Hybrid Materials and π-system Synergisms

An Old but Lively Nanomaterial: Exploiting Carbon Black for the Synthesis of Advanced Materials

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