Antimicrobial properties of hydrophobic compounds in garlic: Allicin, vinyldithiin, ajoene and diallyl polysulfides (Review)

Nakamoto, Masato; Kunimura, Kayo; Suzuki, Junichiro; Kodera, Yoshihisa

doi:10.3892/etm.2019.8388

Cited by 89 publications

(84 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consequently, QS is considered a promising target for new antibiofilm agents. Moreover, QS inhibitors (enzymes and auto-inducing peptides) or RNA-III-inhibiting peptides [ 65 ], halogenated furanone compounds [ 73 ], quercetin [ 74 ], curcumin [ 33 ], and even ginseng extract or garlic extract [ 75 , 76 ] contribute to overcoming the bacterial resistance in biofilm.…”

Section: Characterization Of Bacterial Biofilmsmentioning

confidence: 99%

Bacteriophage-Derived Depolymerases against Bacterial Biofilm

et al. 2021

View full text Add to dashboard Cite

In addition to specific antibiotic resistance, the formation of bacterial biofilm causes another level of complications in attempts to eradicate pathogenic or harmful bacteria, including difficult penetration of drugs through biofilm structures to bacterial cells, impairment of immunological response of the host, and accumulation of various bioactive compounds (enzymes and others) affecting host physiology and changing local pH values, which further influence various biological functions. In this review article, we provide an overview on the formation of bacterial biofilm and its properties, and then we focus on the possible use of phage-derived depolymerases to combat bacterial cells included in this complex structure. On the basis of the literature review, we conclude that, although these bacteriophage-encoded enzymes may be effective in destroying specific compounds involved in the formation of biofilm, they are rarely sufficient to eradicate all bacterial cells. Nevertheless, a combined therapy, employing depolymerases together with antibiotics and/or other antibacterial agents or factors, may provide an effective approach to treat infections caused by bacteria able to form biofilms.

show abstract

Section: Characterization Of Bacterial Biofilmsmentioning

confidence: 99%

Bacteriophage-Derived Depolymerases against Bacterial Biofilm

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Allicin(diallyl thiosulfinate) possess a documented anti-fungal, antiviral, anti-parasitic and anti-bacterial activity [35,37] . It has been reported to exhibit a broad-spectrum antimicrobial activity, even against multidrug-resistant bacteria [38][39][40] .…”

Section: Introductionmentioning

confidence: 99%

“…Allicin can cross cell membranes and combine with sulfur-containing molecular groups in proteins. Consequently, there is oxidation of glutathione with the induction of microbial apoptosis [37,39,41] .…”

Section: Introductionmentioning

confidence: 99%

“…Tomex plus (TP) is an Egyptia nmade, commercially available enteric-coated tablet of dried garlic powder extract with allicin. Allicin is considered to be a potent prebiotic [20,37,39] that is sold under different brand names. Many brands of garlic are manufactured as enteric-coated tablets to prevent its` disintegration in the stomach.…”

Section: Introductionmentioning

confidence: 99%

“…Many brands of garlic are manufactured as enteric-coated tablets to prevent its` disintegration in the stomach. The enzyme alliinase -required for allicin release from garlicis inactive at pH 3.5 or lower [36,37,40] .Additionally, besides being rich in allicin, TP also contains many essentials micronutrients, like vitamin A, C and E and zinc. Jointly, these micronutrients play a pivotal role in maintaining the functional integrity of mucosal cells, collagen and Lymphocytes and protect cell membranes from damage caused by free radicals, as well [44] .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical and Microbiological Evaluation of the Effect of Heat Killed Lactobacillus Acidophilus and Garlic Extract on Candida Albicans in a Group of Elderly Denture Wearers

Abdelhameed

Abdullah

2021

Egyptian Dental Journal

View full text Add to dashboard Cite

Continuous denture wearing, lack of adequate hygiene and infection with Candida albicans (C. albicans) are among the etiological factors of Denture stomatitis (DS). The management of DS ranges from the implementation of oral hygiene measures and removal of predisposing factors to the use of antifungals, depending on the severity of inflammation. Aim of the study:This study aimed to evaluate the short-term effect of heat killed lactobacillus acidophilus -Lacteol Fort® (LF)-as a probiotic and garlic extract -Tomex Plus® (TP)-as a prebiotic on salivary C. albicans counts and biofilm-forming ability, in elderly denture wearers with DS.Methods: This was a single-center, single-blind, randomized pilot clinical trial. 27 complete denture wearers were randomly allocated into 3 groups; group I (control), group II (LF) and group III (TP). Each group was clinically assessed for DS and microbiologically evaluated for salivary C. albicans counts at baseline and after 15 days. The biofilm-forming ability of salivary C. albicans was assessed, as well, for each group at the end of the experimental period.Results: Clinical assessment revealed a reduction in the total erythematous area dimension from 3.00 ± 0.40 mm for group II (LF) and from 3.20 ± 0.54 mm for group III (TP) to ≤2 mm for either group after treatment. Microbiological evaluation showed that C. albicans counts and biofilm-forming ability were significantly lowered in groups II (LF) and III (TP). Conclusion:LF and TP were both found to be effective in reducing DS associated inflammation, C. albicans counts and biofilm-forming ability.

show abstract

Plant‐derived virulence arresting drugs as novel antimicrobial agents: Discovery, perspective, and challenges in clinical use

Lu,

Wang,

Wang

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

Antimicrobial resistance (AMR) emerges as a severe crisis to public health and requires global action. The occurrence of bacterial pathogens with multi‐drug resistance appeals to exploring alternative therapeutic strategies. Antivirulence treatment has been a positive substitute in seeking to circumvent AMR, which aims to target virulence factors directly to combat bacterial infections. Accumulated evidence suggests that plant‐derived natural products, which have been utilized to treat infectious diseases for centuries, can be abundant sources for screening potential virulence‐arresting drugs (VADs) to develop advanced therapeutics for infectious diseases. This review sums up some virulence factors and their actions in various species of bacteria, as well as recent advances pertaining to plant‐derived natural products as VAD candidates. Furthermore, we also discuss natural VAD‐related clinical trials and patents, the perspective of VAD‐based advanced therapeutics for infectious diseases and critical challenges hampering clinical use of VADs, and genomics‐guided identification for VAD therapeutic. These newly discovered natural VADs will be encouraging and optimistic candidates that may sustainably combat AMR.

show abstract

Antimicrobial properties of hydrophobic compounds in garlic: Allicin, vinyldithiin, ajoene and diallyl polysulfides (Review)

Cited by 89 publications

References 47 publications

Bacteriophage-Derived Depolymerases against Bacterial Biofilm

Bacteriophage-Derived Depolymerases against Bacterial Biofilm

Clinical and Microbiological Evaluation of the Effect of Heat Killed Lactobacillus Acidophilus and Garlic Extract on Candida Albicans in a Group of Elderly Denture Wearers

Plant‐derived virulence arresting drugs as novel antimicrobial agents: Discovery, perspective, and challenges in clinical use

Contact Info

Product

Resources

About