Antimicrobial properties of model drugs in the systemic concept of health

Abstract

Keywords: KTIOL Drug Microorganism Resistance E. сoli Antimicrobial HealthIntroduction. We analyzed the antimicrobial efficacy of the investigated preparations of the KTIOL-BF series on standard culture of microorganisms: S. aureus, Escherichia coli, P. aeruginosa and S. saprophyticus.Materials and methods. The model preparations of the KTIOL-BF series (biofunctional) are studied. The preparations are based on vegetable and animal extracts containing iodine solution or do not contain it. As controls, preparations of povidone iodine and chlorophyll are used. The antimicrobial properties of the samples of the preparations were determined by the modified diffusion method ("wall" method) for increasing the upper range of evaluation.Results and discussion. The scientific basis of this study is the systematic concept of health, developed on the basis of the KTIOL-I ecological-technological system and the physiologically functional system KTIOL-II. The preparation on the basis of herbal extract provided the initial good antimicrobial effect on all microorganisms studied. Introduction to the preparation based on extracts of plants and on the basis of plant and animal extracts with solution of nanosized particles of colloidal silver up to 35 wt. % slightly reduced the antimicrobial effect of the samples relative to S. aureus and S. saprophyticus. The sample on the basis of plant and animal extracts showed a good antimicrobial effect on microorganisms S. Saprophyticus, E. coli, P. aeruginosa. Two samples showed a good antimicrobial effect on all studied microorganisms.Model samples of the preparation on the basis of two-phase plant modified enzymes produced a very good integral antimicrobial effect on all microorganisms studied. Of these, two samples based on extracts of plants and on the basis of plant and animal extracts showed high antimicrobial effects on the E. coli strain (30 mm growth retardation diameter).The possibility of high antimicrobial action on E. coli strain (30 mm diameter growth delay) has been confirmed. This is due to the complex action of these two samples on the study of gram-positive and gram-negative strains of microorganisms.Conclusions. The possibility of high antimicrobial activity of samples on the basis of two-phase plant extract and on the basis of plant extract and iodine solution on strain Escherichia coli was revealed and confirmed. The same specimens showed high and good antimicrobial properties, both in other strains, and in an integral manner.

Antimicrobial and antifungal activity of model drugs on the basis of food plant extracts in the systemic concept of health

“…Innovative pharmacokinetic products, drugs based on medicinal and food plants and auxiliary active ingredients are presented in [1,4,9,12].…”

“…Systemic concept of health (The systems KTIOL ® : 10 Basic Provisions for Prevention, Recovery, Treatment, and Rehabilitation). The study of antimicrobial and antifungal model samples of drugs is based on the theory and practice of using KTIOL-I and KTIOL-II systems [1,3,4,8,9,12].…”