Antimicrobial Properties of Plectranthus ornatus Extracts, 11-acetoxyhalima-5, 13-dien-15-oic Acid Metabolite and its Derivatives

Rijo, Patrícia; Rodrı́guez, Benjamı́n; Duarte, Aida; Simões, Fátima

doi:10.2174/2210316311101010057

Cited by 11 publications

(23 citation statements)

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“…This analysis revealed the presence of compounds like diterpenes, triterpenes, and flavonoids, which are known to exhibit antimicrobial activities that inhibit bacterial growth (Table IV). Therefore, we can assume that the antimicrobial activity observed in crude extracts may well be associated with these types of compounds (Figure 3) (Rijo et al 2011, Roberto et al 2007.…”

Section: ˗1mentioning

confidence: 97%

Antibiotic activity of Plectranthus ornatus Codd., a Traditional Medicinal Plant

Nascimento

Albuquerque

Oliveira

et al. 2017

An. Acad. Bras. Ciênc.

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The dichloromethane extract of Plectranthus ornatus Codd., a tradicional medicinal plant, showed antibiotic activity with minimum inhibitory concentration (MIC) values of 0.4 mg.mL -1 and 100 percent of biofilm inhibition against Staphylococcus aureus strains isolated from animals with mastitis infections. Based on these antibacterial activities, in addition to ethnopharmacological reports from healing men and farmers in Brazil, an herbal soap was produced from this active extract and was tested both in vitro and in vivo. In vivo assays conducted on these herbal soaps led to results similar to those previously conducted with the active extract. These results indicated the great potential of this plant for use as an excipient by preparing herbal antibacterial soaps as an alternative veterinary medicine aimed at controlling bovine mastitis infections on small Brazilian farms.

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Section: ˗1mentioning

confidence: 97%

Antibiotic activity of Plectranthus ornatus Codd., a Traditional Medicinal Plant

Nascimento

Albuquerque

Oliveira

et al. 2017

An. Acad. Bras. Ciênc.

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“…In developing countries, it is estimated that about 80% of the population rely on traditional medicine for their primary health care. Therefore, there is a need to screen medicinal plants for potential bioactive compounds of therapeutic value and as sources of lead compounds in (2,3) drug development . The Plectranthus genus belongs to the Lamiaceae family and has about 350 species that are distributed in tropical and subtropical regions of Asia, Africa, Australia, Madagascar, India and the Pacific Islands.…”

Section: Introductionmentioning

confidence: 99%

“…Phytochemical studies using some species of Plectranthus revealed the presence of a large number of diterpenes and triterpenes. The terpenoids are considered to be the main responsible compounds for the antimicrobial and antioxidant activities presented by (3) Plectranthus species . Antioxidants mitigate the harmful effect of free radicals, which damage human cells under 'oxidative stress' conditions.…”

Section: Introductionmentioning

confidence: 99%

“…Nos países em desenvolvimento estima-se que cerca de 80% da população dependa da medicina tradicional para os cuidados primários de saúde. Sendo assim, surge a necessidade de fazer uma triagem das plantas medicinais para obtenção de potenciais compostos bioativos de valor terapêutico e como fontes de compostos protótipo no (2,3) desenvolvimento de fármacos . O género Plectranthus pertencente à família Lamiaceae tem cerca de 350 espécies que são distribuídas em regiões tropicais e subtropicais da Ásia, África, Austrália, Madagáscar, Índia e Ilhas do Pacífico.…”

Section: Introductionunclassified

“…gama de doenças Estudos fitoquímicos que utilizam algumas espécies de Plectranthus revelaram a presença de um grande número de diterpenos e triterpenos. Os terpenóides são considerados os principais compostos responsáveis pelas actividades antimicrobiana e (3) antioxidante presentes nas espécies de Plectranthus . Os antioxidantes atenuam os efeitos nocivos dos radicais livres, que danificam as células humanas sob condições de "stress oxidativo".…”

Section: Introductionunclassified

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Screening of antioxidant and antimicrobial activities on Plectranthus spp. extracts

Rijo

Batista

Matos

et al. 2018

BBR

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J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c a Screening of antioxidant and antimicrobial activities on Plectranthus spp. extracts Pesquisa das actividades antioxidante e antimicrobiana em extractos de plantas do género Plectranthus__________________________________________________________________________________ AbstractThe use of medicinal plants is a widespread tendency in folk medicine. The Lamiaceae family contains several genera such as sage (Salvia), basil (Ocimum) and mint (Mentha) with a rich diversity of ethnobotanical uses. This study presents the in vitro antibacterial and antioxidant activities evaluation of five species extracts of the Plectranthus genus: P. hadiensis (vr), P. madagascarensis, P. neochilus, P. verticillatus e P. barbatus. Aqueous and acetonic extracts were obtained by five different methods: infusion, decoction, ultrasounds, microwave and maceration (10% w / v of dry plant). The highest amount of dry extract was obtained by the infusion method for Plectranthus barbatus (22,0 ± 1,0 to 33,0 ± 3,0 mg/mL). The extracts obtained were tested for their antimicrobial activity against three Gram-positive bacteria and two Gram-negative bacteria using the well diffusion method. Only the acetonic extracts of P. madagascarensis, P. hadiensis (vd) and P. verticillatus showed antibacterial activity and this was exclusively against Gram-positive bacteria. The highest antimicrobial activity was exhibited by P. madagascarensis extract with inhibition zones ranging from 23 to 36 mm. The antioxidant activity of the extracts was qualitatively determined using the 2,2-diphenyl-l-picrylhydrazyl (DPPH) radical assay in tlc and yielded positive results for the majority of the extracts studied.Keywords: Plectranthus, antioxidant activity, antimicrobial activity. ___________________________________________________________________________________________________ Resumo ___________________________________________________________________________________________

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Diterpenoids from Leaves of Cultivated Plectranthus ornatus

et al. 2020

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Two new diterpenoid derivatives 7α,12β,17-triacetoxy-6β,19-dihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione (1) and 6β-acetoxy-3β,7α,12α-trihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione (2) along with 11 (3–13) miscellaneous compounds were isolated from the leaves of Plectranthus ornatus Codd. Their structures were elucidated by spectroscopic analysis and gauge independent atomic orbitals 13C NMR calculations. The isolated compounds were screened for their effects on intestinal motility using guinea-pig ileum and duodenum and by their cytotoxicity against 4 human cancer cell lines (HCT-116, SF-295, PC-3, and HL-60). Compounds 6 and 9 were moderately cytotoxic against HL-60, whereas 6 and 13 were more active on SF-295 and HCT-116.

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Antimicrobial Properties of Plectranthus ornatus Extracts, 11-acetoxyhalima-5, 13-dien-15-oic Acid Metabolite and its Derivatives

Cited by 11 publications

References 0 publications

Antibiotic activity of Plectranthus ornatus Codd., a Traditional Medicinal Plant

Antibiotic activity of Plectranthus ornatus Codd., a Traditional Medicinal Plant

Screening of antioxidant and antimicrobial activities on Plectranthus spp. extracts

Diterpenoids from Leaves of Cultivated Plectranthus ornatus

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