Antimicrobial Prophylaxis in
Urologic Surgery:
Does It Give Some Benefit?

Rió, G. Del; Dalet, F; Chéchile, G

doi:10.1159/000474318

Cited by 18 publications

(3 citation statements)

References 7 publications

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“…The rationale behind the effect of immunosuppression on wound infection and healing could be attributed to less inflammatory responses to microorganisms and to the lengthening of the healing process induced by steroids. 11,12 Beyond immunosuppression, renal transplant recipients may run a greater risk for developing SIIs, due to preexisting medical conditions such as diabetes mellitus (DM) and end-stage renal disease. The incision made in renal transplant recipients is assumed to be contaminated because the urinary bladder is opened to perform the ureterocystostomy anastomosis, and urine spillage after bladder opening could increase the risk of wound infections in patients undergoing kidney transplant.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Moris

Davakis²,

Kakavia³

et al. 2017

Exp Clin Transplant

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Objectives: Surgical incision infections, along with urinary tract infections, are among the most common infective complications after kidney transplant. The aim of this retrospective study is to evaluate the incidence and predisposing factors of surgical incision infection development in renal transplant recipients. Further evaluation of these findings in a prospective study is needed to avoid potential bias.

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Section: Introductionmentioning

confidence: 99%

Untitled

Moris

Davakis²,

Kakavia³

et al. 2017

Exp Clin Transplant

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“…With the use of multidose prophylaxis, the emergence of antimicrobial agent-resistant bacteria related to the use of prophylactic ceftriaxone could be reason for concern. Data suggest that prolonged (Ͼ48-h) postoperative prophylaxis is responsible for modification of susceptibility to antimicrobial agents (7,8), but no deleterious effect caused by an appropriate short-course prophylactic regimen has been reported. Such data should preclude the use of multiple-dose antibiotic regimens, and a consistent effort should be made to use short-course or single-dose prophylaxis whenever possible.…”

mentioning

confidence: 99%

“…In urologic surgery, a single dose of antibiotic for prophylaxis has been shown to offer at least the same advantages as multiple-dose therapy in terms of clinical efficacy. In addition, the single-dose therapy selected for both the resistant strains and the numerous microbial associations in lesser proportions (8).…”

mentioning

confidence: 99%

Concentrations of ceftriaxone (1,000 milligrams intravenously) in abdominal tissues during open prostatectomy

Martin

Viviand

Cottin

et al. 1996

Antimicrob Agents Chemother

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Ceftriaxone concentrations in abdominal tissues were evaluated at different stages of open prostatectomy. Ceftriaxone was administered as antibiotic prophylaxis, and 15 consecutive patients were given a single dose of ceftriaxone (1,000 mg intravenously in 1 min) 30 min before surgery. Ceftriaxone concentrations in tissue were determined at three stages of the surgical procedure; upon the opening of the abdominal cavity, during the prostatectomy, and upon the closure of the abdominal cavity. Samples of the following tissues or sample were assayed: epiploic and abdominal-wall fat; Retzius' space, bladder, and prostate tissue; and urine. During the different stages of the surgical procedure, for all patients, and in the different tested tissues, ceftriaxone concentrations greater than or equal to the cutoff point (4 micrograms/g of tissue) were measured. The highest concentrations were obtained in the bladder (43 +/- 18 micrograms/g) and in the prostate (35 +/- 18 micrograms/g). In fatty tissues, concentrations were between 13 +/- 5 and 22 +/- 8 micrograms/g. All patients (15 of 15) had ceftriaxone levels in tissue greater than the MICs for the potential pathogens (Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis). In conclusion, during open prostatectomy and after the use of a single dose of ceftriaxone (1,000 mg), high antibiotic levels were obtained throughout the surgical procedure in the tissues potentially involved in postoperative infection.

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