Antimicrobial resistance among Brazilian Corynebacterium diphtheriae strains

Pereira, Geraldo; Pimenta, Fabricia Pires; Santos, Fátima Rejane Wink dos; Damasco, Paulo Vieira; Júnior, Raphael Hirata; Mattos‐Guaraldi, Ana Luíza

doi:10.1590/s0074-02762008000500019

Cited by 43 publications

(37 citation statements)

References 20 publications

(26 reference statements)

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“…Based on the study, clinician must reconsider the use of resistant to b-lactams antibiotic if the clinical condition of patient with systemic infection does not improve after being treated with b-lactams antibiotics. (6) According to CLSI document M45-A2 guideline, the microdilution broth method is recommended in C. diphtheriae susceptibility testing. We already conducted our research with this method by using an automated reading incubation system (ARIS) (Thermo Scientific, Massachusetts, USA) to determine dentification and antimicrobial susceptibility testing of C. diphtehriae, nevertheless there are several limitations of the sensititre ARIS.…”

Section: Resultsmentioning

confidence: 99%

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Antibiotic Susceptibility Pattern of Corynebacterium diphtheriae Isolated from Outbreaks in Indonesia 2010-2015

Sariadji¹,

Sunarno²,

Puspandari³

et al. 2018

Indones Biomed J

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BACKGROUND: Diptheria cases are treated with both anti-diphtheria serum (ADS) and antibiotics. Penicillin and erythromycin are the primary choices for any Corynebacterium diphtheriae (C. diphtheriae) infection. Antibiotic susceptibility pattern of C. diphtheriae has not been reported in Indonesia since 1982. The improper use of antibiotics, as well as, the consumption of antibiotics without prescription, will increase the resistance of C. diphtheriae. This study aims to determine the susceptibility pattern and the effectiveness of C. diphtheriae to several antibiotics.METHODS: A total of 57 C. diphtheriae isolates were recultured by using Blood Agar (BA) and Cystine Tellurite Blood Agar (CTBA). Afterward, these isolates were identified by using API Coryne. The antibiotic susceptibility pattern was determined by using Kirby Bauer Method based on CLSI M45-A2.RESULTS: These studies revealed that as the primary choice of diphtheria cases, 10.5% of C. diphtheriae isolates were resistant to Penicillin and 5.3% were resistant to erythromycin. Seven isolates (12%) showed resistance to more than one antibiotics, such as tetracycline and clindamycin, vancomycin and clindamycin, penicillin and tetracycline, also penicillin and vancomycin. Moreover, 4 isolates (7%) were resistant to 3-5 antibiotics. All isolates were susceptible to moxifloxacin and linezolid.CONCLUSION: Some C. diphtheriae isolates were resistant to penicillin and erythromycin, which are known as the primary choice for the treatment of C. diphtheriae infection. Even though, all isolates susceptible to moxifloxacin and linezolid.KEYWORDS: Corynebacterium diphtheriae, resistance, antimicrobial

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Section: Resultsmentioning

confidence: 99%

“…However, it has been reported that there are C. diphtheriae which resistant to penicillin, oxacillin, erythromycin, rifampicin, tetracycline and clindamycin. (4)(5)(6). Another problem that has been identified in the treatment of diphtheria is the increase of multidrug resistance C. diphtheriae.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic Susceptibility Pattern of Corynebacterium diphtheriae Isolated from Outbreaks in Indonesia 2010-2015

Sariadji¹,

Sunarno²,

Puspandari³

et al. 2018

Indones Biomed J

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“…Antimicrobial resistance against either penicillin or erythromycin, the two antibiotics of choice in eliminating diphtheria-causing corynebacteria, has been described both in C. diphtheriae-albeit very rarely (Coyle et al 1979;Dixon 1984;Engler et al 2001b;Kneen et al 1998;Mina et al 2011;Pereira et al 2008;von Hunolstein et al 2002) and C. ulcerans (Schuhegger et al 2009;Tiwari et al 2008). Therefore, antibiotic sensitivity testing is highly recommended.…”

Section: Antimicrobial Resistance Testingmentioning

confidence: 99%

Detection Methods for Laboratory Diagnosis of Diphtheria

Berger

Hogardt

Konrad

et al. 2013

Corynebacterium Diphtheriae and Related Toxigenic Species

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Although diphtheria has to be diagnosed primarily on clinical symptoms, the rapid and reliable detection and identification of the potentially toxigenic Corynebacterium species, C. diphtheriae, C. ulcerans and C. pseudotuberculosis, is essential for the definite diagnosis and management of diphtheria with respect to both the individual patient and the public health measures to be undertaken. Laboratory confirmation of suspected diphtheria has to aim for the isolation of the etiologic pathogen (including species identification and antibiotic susceptibility testing) as well as for differentiation of toxigenic from non-toxigenic strains (by using tox gene detection and toxigenicity testing). The recent introduction of the Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) into the microbiological algorithm of laboratory diagnosis of diphtheria allows the specific and escalating identification of the three potentially toxigenic Corynebacterium species from growing colonies. Finally, molecular typing techniques may be applied to explore the clonal relatedness of clinical isolates and their potential routes of transmission. The most relevant laboratory procedures fulfilling these requirements (microbiological culture, conventional biochemical tests, molecular methods for species identification and toxigenicity testing) will be presented here.

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“…As a consequence of the decreased prevalence of diphtheria, there has been a recent surge in NTCD infections, especially invasive diseases including IE, in countries such as Brazil [14], France [8,15], India [11], Poland [9], the United Kingdom [6], the United States [4,12], and New Zealand [7].…”

Section: Discussionmentioning

confidence: 99%

“…Penicillin and gentamicin are known to act synergistically, and the NTCD endocarditis treatment with both the antibiotics may have contributed to the favorable outcome in this study. However, multidrugresistant C. diphtheriae strains have also been isolated [14], and NTCD strains resistant to penicillin and third-generation cephalosporins have been reported in patients with IE [10]. Since the mortality rate attributed to Corynebacterium endocarditis is high (43.4%) [22], effective and prompt patient-specific management, including clinical expertise, advanced cardiac imaging, and antibiotic therapy may also have contributed to better outcomes.…”

Section: Discussionmentioning

confidence: 99%

Late-onset prosthetic valve endocarditis caused by nontoxigenic Corynebacterium diphtheriae

El‐Hazmi

2015

J Infect Dev Ctries

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In developed countries, Corynebacterium diphtheriae infection is rare due to efficient immunization programs. However, cases of nontoxigenic strains of C. diphtheriae infections, including endocarditis, have been reported recently. Although the incidence remains low, these infections are associated with high morbidity and mortality. This report describes the first and atypical case of bacteremia and endocarditis caused by nontoxigenic C. diphtheriae var. gravis after introduction of immunization in the Kingdom of Saudi Arabia (KSA).

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Antimicrobial resistance among Brazilian Corynebacterium diphtheriae strains

Cited by 43 publications

References 20 publications

Antibiotic Susceptibility Pattern of Corynebacterium diphtheriae Isolated from Outbreaks in Indonesia 2010-2015

Antibiotic Susceptibility Pattern of Corynebacterium diphtheriae Isolated from Outbreaks in Indonesia 2010-2015

Detection Methods for Laboratory Diagnosis of Diphtheria

Late-onset prosthetic valve endocarditis caused by nontoxigenic Corynebacterium diphtheriae

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