Antimicrobial resistance (AMR) and plant-derived antimicrobials (PDAms) as an alternative drug line to control infections

Srivastava, J. N.; Chandra, Harish; Nautiyal, A. R.; Kalra, Swinder Jeet Singh

doi:10.1007/s13205-013-0180-y

Cited by 93 publications

(65 citation statements)

References 86 publications

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“…Unfortunately, this is true only for the developed part of the world. Despite being rich in natural resources, the underdeveloped countries such as India, China, and North East of Central Africa could not make the proper use of resources because of poor economy and higher population growth rate . Initiatives taken by world countries to improve quality of life and the life expectancy in the developing world led the production of synthetic antibiotics.…”

Section: Risk Associated With Microbial Resistancementioning

confidence: 99%

Understanding the Development of Environmental Resistance Among Microbes: A Review

Srivastava¹,

Chandra

Singh

et al. 2016

CLEAN Soil Air Water

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Indiscriminate industrial development and increased human population have altered the environmental conditions all over the world, creating challenges for various life forms on earth. Environmental pollutants such as toxic metals and hazardous organic compounds are fatal for life and the most concerned global issue of the debates. Microbes are integrated part of all ecosystems and without the microbial activity, sustainability of ecosystems is impossible. Environmental pollutants exert huge selection pressure on environmental microbial community and eventually cause the evolution of genetically stable determinants. Scientific contributions in the last two decades has strengthened our knowledge of extensively drug resistant variants of microbes, intrinsic and acquired resistance among microbes, and the exchange of the genetic information between them. Understanding of environmental resistance among microbes, scientific researches directly link two different field viz., medical and environmental microbiology. Bacterial species such as Acinetobacter baumannii, Bacillus cereus, and Escherichia coli are reported to have resistance against both, the toxic metals and antibiotics. This paper reviews the development of environmental resistance among microbes having resistance to antibiotics along with the gist of associated environmental risk.

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Section: Risk Associated With Microbial Resistancementioning

confidence: 99%

Understanding the Development of Environmental Resistance Among Microbes: A Review

Srivastava¹,

Chandra

Singh

et al. 2016

CLEAN Soil Air Water

Self Cite

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“…Two-thirds of deaths from infections in 2010 were reported to be caused by around 20 species, mainly bacteria and viruses (Dye, 2014). Novel, effective and affordable drugs are needed to combat infectious diseases especially in developing countries of the world; where up to one-half of deaths are due to infectious diseases (Awouafack et al, 2013;Srivastava et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant and antimicrobial activities of Pistacia lentiscus, Phyllanthus anderssonii and Cinnamomum verum crude extracts and fractions

Alhadi¹,

Hamdi²,

Ayoub³

et al. 2018

J. Med. Plants Res.

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In this study, phytochemical screening, antioxidant and antimicrobial activities of ethanolic (80%) extracts from leaf and stem of Pistacia lentiscus and Phyllanthus anderssonii and leaf of Cinnamomum verum and their fractions were evaluated. Antimicrobial activity was performed by disc diffusion method. The antioxidant activity was determined by stable 1, 1-diphenyl-2-picryl hydrazyl (DPPH) free radical method. Fractionation improved the antimicrobial activity of P. lentiscus and C. verum. The ethyl acetate fraction of P. lentiscus leaf showed higher activity against Bacillus subtilis (

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“…Infectious diseases caused by AMR microbes and the treatment are the serious problems in the field of medical science today world over. The development of an alternative drug line to treat such infectious diseases is urgently required [6]. Developing world, especially the countries of Southeast Asia, Western and Central Africa, India, and Pakistan are the most vulnerable to various infectious pandemic diseases [7].…”

Section: Introductionmentioning

confidence: 99%

Gas Chromatography-Mass Spectrometry Analysis and in Vitro Antimicrobial Screening of Wedelia Glauca (Ortega) O. Hoffm. Ex Hicken

Krishnavignesh

Mahalakshmipriya²,

Ramesh³

2017

Asian J Pharm Clin Res

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Objective: Continued resistance toward the antibiotics urges us to explore newer antibiotics. Plants are being the safer source of antibiotics with lesser or no side effects. This study was designed to study the presence of phytochemical constituents and antibacterial activity of leaf and flower extracts of Wedelia glauca against urinary tract infection causing pathogens. Methods:The plant leaves were extracted with five different solvents based on the polarity. The extraction was done using soxhalation. Antimicrobial activity was determined by agar well diffusion method for both the sample and standard. The acetone plant extract was subjected to gas chromatography-mass spectrometry (GC-MS) analysis for screening phytoconstituents.Results: Preliminary phytochemical screening revealed the presence of diverse phytoconstituents in the plant. The different extracts exhibited a considerable antimicrobial potential. Among the solvents used acetone extract showed comparably better antimicrobial activity with 100% of inhibition rate with the maximum zone of inhibition of 1.6±0.77 mm against Staphylococcus sp. and Aspergillus sp. at the concentration of 5 mg. GC-MS analysis provided 8 major peaks which revealed the existence of a variety of bioactive compounds which may attribute to the efficacy of the plant. Conclusion:W. glauca leaf and flower extracts displayed a broad spectrum of antibacterial and antifungal activity and can be considered as a potential source of newer antibiotic compounds.

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Antimicrobial resistance (AMR) and plant-derived antimicrobials (PDAms) as an alternative drug line to control infections

Cited by 93 publications

References 86 publications

Understanding the Development of Environmental Resistance Among Microbes: A Review

Understanding the Development of Environmental Resistance Among Microbes: A Review

In vitro antioxidant and antimicrobial activities of Pistacia lentiscus, Phyllanthus anderssonii and Cinnamomum verum crude extracts and fractions

Gas Chromatography-Mass Spectrometry Analysis and in Vitro Antimicrobial Screening of Wedelia Glauca (Ortega) O. Hoffm. Ex Hicken

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