Antimicrobial resistance and molecular subtypes of Salmonella enterica serovar Typhi isolates from Kolkata, India over a 15 years period 1998–2012

Das, Surojit; Samajpati, Sriparna; Ray, Ujjwayini; Roy, Indranil

doi:10.1016/j.ijmm.2016.11.006

Cited by 28 publications

(22 citation statements)

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“…Single and/or double point mutations in QRDRs of DNA gyrase and topoisomerase IV genes were found in the study isolates, which was reported earlier from Kolkata (34). The pair of S.…”

Section: Discussionsupporting

confidence: 73%

Report of Relapse Typhoid Fever Cases from Kolkata, India: Recrudescence or Reinfection?

2018

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“…Single and/or double point mutations in QRDRs of DNA gyrase and topoisomerase IV genes were found in the study isolates, which was reported earlier from Kolkata (34). The pair of S.…”

Section: Discussionsupporting

confidence: 73%

Report of Relapse Typhoid Fever Cases from Kolkata, India: Recrudescence or Reinfection?

2018

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“…Typhi limits the treatment options. In spite of suggested regional decreases in the levels of antibiotic resistance ( 6 – 8 ), the first cases of S . Typhi isolates showing multidrug resistance (MDR) (defined as co-occurring resistance to ampicillin [amp], chloramphenicol [chl], and co-trimoxazole [sxt]) were reported in the early 1970s ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Salmonella enterica Serovar Typhi in Bangladesh: Exploration of Genomic Diversity and Antimicrobial Resistance

Tanmoy

Westeel

Bruyne³

et al. 2018

mBio

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Typhoid fever, caused by Salmonella enterica serovar Typhi, is responsible for an estimated burden of approximately 17 million new episodes per year worldwide. Adequate and timely antimicrobial treatment invariably cures typhoid fever. The increasing antimicrobial resistance (AMR) of S. Typhi severely limits the treatment options. We studied whole-genome sequences (WGS) of 536 S. Typhi isolates collected in Bangladesh between 1999 and 2013 and compared those sequences with data from a recent outbreak in Pakistan and a laboratory surveillance in Nepal. The analysis suggests that multiple ancestral origins of resistance against ciprofloxacin and ceftriaxone are present in three countries. Such independent genetic events and subsequent dissemination could enhance the risk of a rapid global spread of these highly resistant clones. Given the current treatment challenges, vaccination seems to be the most appropriate short-term intervention to reduce the disease burden of typhoid fever at a time of increasing AMR.

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“…Integrons are potentially capable to transmit drug resistance to other S. enterica isolates or to other bacteria. Since integron represents the main vehicle of antibiotic resistance, their presence in S. Typhi indicates uninterrupted transfer of drug resistance genes from one organism to another irrespective of their species which are worrisome with respect to the spread of AMR [27].…”

Section: Discussionmentioning

confidence: 99%

First description of class 1 integron in typhoidal Salmonella isolated from clinical and lettuce samples in Burkina Faso.

Somda¹,

Bonkoungou²,

Traoré³

et al. 2019

Preprint

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Background: In Burkina Faso, dirty water, in particular those of the stoppings and the gutter are used for irrigation of vegetables. The aim of this study is to contribute to the knowledge on the molecular level of Salmonella circulating in the hospitals and environment next to hospitals in Burkina Faso. Methods: Salmonella isolated from diarrhea stools between 2009 to 2015 and lettuce samples isolated in 2014 in Burkina Faso were characterized by simple Polymerase Chain Reaction using specific primers. Sequencing was performed using the BigDye terminator protocol on the ABI PRISM 310. The sequences obtained corresponding were searched using the BlastN program.Results: Out of 100 Salmonella isolated, 53% were from human and 47% from lettuce samples. Globally, the highest prevalence was observed with invA, misL, pipD, orfL and spvR genes in 97%, 96%; 74%; and 21%. Forty of these isolates carried class 1 integron, 31 from clinical samples and 9 from lettuce samples. Sequencing showed different gene with aadA1 in 13/15 strains, aadA7 and aac(3)-Id in 2/15 strains. Eight percent (8/100) of Salmonella harbored gyrB and parE genes. Sequencing showed no mutation in these genes. Three distinct Pulsed-Field Gel Electrophoresis (PFGE) types were observed from clinical samples with 90-95% similarity in each case. All Salmonella from lettuce had similar pulsotypes. Conclusion: This study showed that lettuce is a potential source of transmission of Salmonella causing diarrhea among human in Burkina Faso.

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Antimicrobial resistance and molecular subtypes of Salmonella enterica serovar Typhi isolates from Kolkata, India over a 15 years period 1998–2012

Cited by 28 publications

References 50 publications

Report of Relapse Typhoid Fever Cases from Kolkata, India: Recrudescence or Reinfection?

Report of Relapse Typhoid Fever Cases from Kolkata, India: Recrudescence or Reinfection?

Salmonella enterica Serovar Typhi in Bangladesh: Exploration of Genomic Diversity and Antimicrobial Resistance

First description of class 1 integron in typhoidal Salmonella isolated from clinical and lettuce samples in Burkina Faso.

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