Antimicrobial Resistance and Respiratory Infections

Guitor, Allison K; Wright, Gerard D.

doi:10.1016/j.chest.2018.06.019

Cited by 71 publications

(48 citation statements)

References 105 publications

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“…First, stimulation of innate immunity by synergistic agonist combinations is a potential tool for prevention of infectious diseases. This approach becomes more and more relevant because of the growing problem of infections caused by antibiotic‐resistant bacterial strains, necessitating the development of treatment and prevention strategies that would complement or substitute for traditional antibiotics. Second, simultaneous blockade of synergistically acting receptors and/or signaling pathways could ameliorate excessive inflammatory response in ongoing sepsis.…”

Section: Potential Clinical Relevance Of Nod‐tlr Synergymentioning

confidence: 99%

Synergistic interactions between NOD receptors and TLRs: Mechanisms and clinical implications

Pashenkov

Murugina

Будихина

et al. 2018

Journal of Leukocyte Biology

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Interactions between pattern recognition receptors (PRRs) shape innate immune responses to particular classes of pathogens. Here, we review interactions between TLRs and nucleotide‐binding oligomerization domain 1 and 2 (NOD1 and NOD2) receptors, two major groups of PRRs involved in innate recognition of bacteria. Most of experimental data both in vitro and in vivo suggest that NODs and TLRs synergize with each other at inducing the production of cytokines and antimicrobial peptides. Molecular mechanisms of this synergy remain poorly understood, although several scenarios can be proposed: (i) direct interactions of signaling pathways downstream of NODs and TLRs; (ii) mutual transcriptional regulation of unique components of NOD‐dependent and TLR‐dependent signaling pathways; and (iii) interactions at the post‐transcriptional level. Potential practical implications of NOD‐TLR synergy are dual. In sepsis, where synergistic effects probably contribute to excessive proinflammatory cytokine production, blockade of NOD1, and/or NOD2 in addition to TLR4 blockade may be required to achieve therapeutic benefit. On the other hand, synergistic combinations of relatively small doses of NOD and TLR agonists administered before infection could be used to boost innate resistance against bacterial pathogens.

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Section: Potential Clinical Relevance Of Nod‐tlr Synergymentioning

confidence: 99%

Synergistic interactions between NOD receptors and TLRs: Mechanisms and clinical implications

Pashenkov

Murugina

Будихина

et al. 2018

Journal of Leukocyte Biology

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“…As a consequence, antibiotic resistance is a significant problem, even though it is not generalizable to all bacteria and antibiotics; in fact, penicillin resistance with Streptococcus pyogenes has not been described, and resistance with other antibiotics is absent or low. Instead, resistance with H. influenzae and S. pneumoniae is more problematic with some antibiotics and not with others, and the prevalence of resistance varies geographically [20][21][22]. Moreover, bacteria create a biofilm, such as thinly layered colonies, which cause antibiotic unsuccess and need surgery [23,24].…”

Section: Introductionmentioning

confidence: 99%

Local Bacteriotherapy – a promising preventive tool in recurrent respiratory infections

Ciprandi

Mantia

Damiani³

et al. 2020

Expert Review of Clinical Immunology

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Introduction: Children with recurrent respiratory infections (RRI) represent a social issue for the economic burden and the negative family impact. Local Bacteriotherapy is an attractive therapeutic strategy that could be potentially effective in preventing infections. The current article remarks on the existing evidence of preventing RRI by Local Bacteriotherapy. Areas covered: The literature search methodology was based on the articles cited by PubMed from 1980 to 2020. Respiratory infections include rhino-pharyngitis, otitis media, rhinosinusitis, pharyngotracheitis, bronchitis, and pneumonia. Several studies were performed to investigate the effects of Local Bacteriotherapy in children with RRI. Both intranasal and oral Local Bacteriotherapy were evaluated. The findings showed that Local Bacteriotherapy significantly reduced the number of RI episodes, their severity, the use of antibiotics, and school absences. Expert opinion: Local Bacteriotherapy is a promising approach to RRI prevention and could be a profitable strategy to contrast infections in the future.

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“…Localized, systemic, and chronic infection diseases are mainly caused by critical propagation of antibiotic/antifungal resistant strains [1], which can result in the formation of a viable biofilm and promote by this way higher resistance to conventional chemotherapeutic treatments [2]. Moreover, clinical and microbiological studies have suggested important deficiencies of the first-line antimicrobial agents selected as therapeutic tools [3,4]. Results from dangerous clinical infections are (but not limited to) surgical wound illnesses, inflammations, immunological diseases, and even dental pathologies that in certain cases conclude mortal sepsis [5].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and In Situ Antifungal and Cytotoxicity Evaluation of Ascorbic Acid-Capped Copper Nanoparticles

Beltrán-Partida

Valdez‐Salas

Valdez-Salas

et al. 2019

Journal of Nanomaterials

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The design route, synthesis, and characterization of spherical copper nanoparticles with antifungal potential are reported in the present work. Copper nanoparticles were synthesized by a novel, inexpensive, and eco-friendly chemical reduction method using ascorbic acid as a reductant and stabilizer under reflux conditions. The characterization results showed the formation of homogeneous, dispersed, and stable spherical ascorbic acid-capped copper nanoparticles (CuNPs) with a diameter of 250 nm. The CuNPs exhibited sustained antifungal activity against Candida albicans (C. albicans) after 24 h and even 48 h of incubation. Using enhanced dark-field microscopy, we presented the in situ interaction between CuNPs and C. albicans. Here, part of the interaction of CuNPs among the C. albicans, studied without the use of any chemical and/or physical fixing method, is discussed. The results indicate that part of the antifungal mechanism involves a promoted adhesion of CuNPs onto the cell wall and a massive accumulation of CuNPs into the fungal cells, concluding in cellular leakage. The cytotoxicity (viability) evaluations indicated that our CuNPs were more biocompatible after comparison to the Cu precursor and triclosan (a commercial antifungal drug). The synthesized CuNPs will open up a new road for their possible use as a potent antimicrobial agent for clinical and industrial applications.

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Antimicrobial Resistance and Respiratory Infections

Cited by 71 publications

References 105 publications

Synergistic interactions between NOD receptors and TLRs: Mechanisms and clinical implications

Synergistic interactions between NOD receptors and TLRs: Mechanisms and clinical implications

Local Bacteriotherapy – a promising preventive tool in recurrent respiratory infections

Synthesis, Characterization, and In Situ Antifungal and Cytotoxicity Evaluation of Ascorbic Acid-Capped Copper Nanoparticles

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