Antimicrobial resistance in pathogens causing nosocomial bloodstream infections in university hospitals in Egypt

Saied, Tamer; Elkholy, Amany; Hafez, Soad; Basim, Hadia; Wasfy, Momtaz O.; El‐Shoubary, Waleed; Samir, Ahmed; Pimentel, Guillermo; Talaat, Maha

doi:10.1016/j.ajic.2011.04.009

Cited by 55 publications

(44 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Inappropriate use of these agents is associated with allergic reactions, toxicity, super infection, and more importantly development of antimicrobial resistance [1]. The excessive and inappropriate use of antibiotics adds an unnecessary economic burden to health care system and coincides with increase in drug resistant organisms [2]. It has been observed in many studies that patients with drug resistant organisms require longer hospitalization and had increased risk of mortality [2].…”

Section: Introductionmentioning

confidence: 99%

“…The excessive and inappropriate use of antibiotics adds an unnecessary economic burden to health care system and coincides with increase in drug resistant organisms [2]. It has been observed in many studies that patients with drug resistant organisms require longer hospitalization and had increased risk of mortality [2]. Rational drug therapy is defined as the use of drugs only when there is specific need.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Trends of Empiric Antibiotic Usage in a Secondary Care Hospital, Karachi, Pakistan

Ali

Ahmed

Lohana

2013

International Journal of Pediatrics

View full text Add to dashboard Cite

Objectives. (1) To determine the indications, frequency, and types of antibiotics used in hospitalized paediatric patients at tertiary care hospital and (2) to evaluate whether the prescribed antibiotics were based on the isolation of organism and their sensitivity. Study Design. Descriptive observational hospital based study. Results. A total of 131 patients were included over 6 months of study period, in whom antibiotics were prescribed at the time of admission. The majority were between 1 and 5 years of age. M : F ratio was 1 : 1. Fever was the commonest symptom (in 84% of cases) followed by gastroenteritis. Blood culture was done in 114 cases (87%) and was positive only in 10 (8.8%). The commonest organism isolated from blood was Salmonella Typhi. Ceftriaxone was found to be the most frequently prescribed antibiotic as an empirical therapy. 102 (77.86%) patients received Ceftriaxone, followed by ampicillin. The antibiotics were probably used on the basis of clinical condition rather than the result of blood culture, as yield of blood culture was quite low. Conclusion. Our study showed an unjustified use of antibiotics regardless of the admission and discharge diagnosis in acute febrile illnesses. Further on, inappropriate practice of using Ceftriaxone was noted in LRTI and pneumonia. Efforts are needed to educate physicians about the rational use of antibiotics.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Trends of Empiric Antibiotic Usage in a Secondary Care Hospital, Karachi, Pakistan

Ali

Ahmed

Lohana

2013

International Journal of Pediatrics

View full text Add to dashboard Cite

show abstract

“…[12][13][14] During the last decade, while IPC activities were progressing in Egypt, it was deemed important to implement a standardized national HAI surveillance program to define the magnitude and scope of HAIs in the country and to allow for interhospital comparisons of HAI rates. Therefore, a plan to implement a nationwide HAI surveillance program in intensive care units (ICUs) was developed with support from several partners: the U.S. Centers for Disease Control and Prevention's (CDC's) Global Disease Detection (GDD) Program in Egypt, the U.S.…”

mentioning

confidence: 99%

National surveillance of health care–associated infections in Egypt: Developing a sustainable program in a resource-limited country

Talaat

El-Shokry

El-Kholy

et al. 2016

American Journal of Infection Control

Self Cite

View full text Add to dashboard Cite

show abstract

“…[7] Antibiotics are used to patients with sepsis in the majority class of cephalosporin that is as much as 42.58%, quinolones at 17.48%, as much as 10.77% carbapenem, aminoglycoside as much as 9.33%, imidazoles as much as 8.85%, others as much as 6, 22%, and macrolides The treatment of de-escalation of antibiotics is one solution that is expected to be used in the treatment of patients with sepsis. From the research results, it was found that patients who receive treatment deescalation therapy were 28.4% and that no de-escalation was 71.6%.…”

Section: Resultsmentioning

confidence: 99%

Antibiotics Administration to Enhance the Success of Therapy in Sepsis Patients

Budi

Ikawati

Dwiprahasto

et al. 2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: Sepsis is reported to cause 9.3% death from the total 250,000 patients in the United States. De-escalation of antibiotics is expected to increase the effectiveness of therapy, to decrease in the level of antibiotic resistance and to reduce mortality in sepsis patients. The purpose of this study was to describe the frequency and characteristics of de-escalation of antibiotics in patients with sepsis and its influence on the patient. Methods:The study was conducted retrospectively with purposive sampling in hospitalized patients in a hospital in Yogyakarta, to the patients whose age are above 15 years, in the month of January to December 2015. Totally, 162 patients were included, in demographic, antibiotic regimens, duration of antibiotic treatment, de-escalation of antibiotics treatment, the culture results, mortality, and Length of Stay (LoS). Result:The result showed that 116 patients were without de-escalation of antibiotics where the majority of cases is the absence of changes in the types of antibiotics that are given from the start of the therapy until the treatment is completed. The age of the most sepsis patients treated is about 46-60 years (36.4%), LoS was 6-10 days highest (27.2%), the number of patients received antibiotics for hospitalized majority 1-2 types of antibiotics (46.9%), originally most of the patients' room are as many as those from emergency unit 63.6%, clinical outcomes patients who were recovered as many as 46.3%, the most comorbidities that frequently appear in sepsis patients is pneumonia is 616.6% cases. Patients who were examined culture is 29%. Conclusion:Giving antibiotics are appropriate and adequate to prevent the possibility of resistance and death, and the de-escalation strategy is a strategy that is safely used to treat patients with sepsis.

show abstract

Antimicrobial resistance in pathogens causing nosocomial bloodstream infections in university hospitals in Egypt

Cited by 55 publications

References 27 publications

Trends of Empiric Antibiotic Usage in a Secondary Care Hospital, Karachi, Pakistan

Trends of Empiric Antibiotic Usage in a Secondary Care Hospital, Karachi, Pakistan

National surveillance of health care–associated infections in Egypt: Developing a sustainable program in a resource-limited country

Antibiotics Administration to Enhance the Success of Therapy in Sepsis Patients

Contact Info

Product

Resources

About