Antibiotics Administration to Enhance the Success of Therapy in Sepsis Patients

Abstract

Objective: Sepsis is reported to cause 9.3% death from the total 250,000 patients in the United States. De-escalation of antibiotics is expected to increase the effectiveness of therapy, to decrease in the level of antibiotic resistance and to reduce mortality in sepsis patients. The purpose of this study was to describe the frequency and characteristics of de-escalation of antibiotics in patients with sepsis and its influence on the patient. Methods:The study was conducted retrospectively with purposive sampling in hospitalized patients in a hospital in Yogyakarta, to the patients whose age are above 15 years, in the month of January to December 2015. Totally, 162 patients were included, in demographic, antibiotic regimens, duration of antibiotic treatment, de-escalation of antibiotics treatment, the culture results, mortality, and Length of Stay (LoS). Result:The result showed that 116 patients were without de-escalation of antibiotics where the majority of cases is the absence of changes in the types of antibiotics that are given from the start of the therapy until the treatment is completed. The age of the most sepsis patients treated is about 46-60 years (36.4%), LoS was 6-10 days highest (27.2%), the number of patients received antibiotics for hospitalized majority 1-2 types of antibiotics (46.9%), originally most of the patients' room are as many as those from emergency unit 63.6%, clinical outcomes patients who were recovered as many as 46.3%, the most comorbidities that frequently appear in sepsis patients is pneumonia is 616.6% cases. Patients who were examined culture is 29%. Conclusion:Giving antibiotics are appropriate and adequate to prevent the possibility of resistance and death, and the de-escalation strategy is a strategy that is safely used to treat patients with sepsis.

Mortality Prevention in Septic Mice With Multiple Organ Dysfunction Syndrome: The Optimal Dose of Intraperitoneal Heat Shock Protein 70

“…De-escalation or streamlining of empirical antimicrobial therapy on the basis of culture results and elimination of redundant combination therapy can more effectively target the causative pathogen, resulting in decreased antimicrobial exposure and substantial cost savings. Hence, de-escalation strategy can be used to treat patients with sepsis [9,10]. However, there are some challenges in implementing de-escalation.…”