Antimicrobial Resistance in Salmonella Isolated from Food Workers and Chicken Products in Japan

Abstract

Salmonella is an enteric bacterial pathogen that causes foodborne illness in humans. Third-generation cephalosporin (TGC) resistance in Salmonella remains a global concern. Food workers may represent a reservoir of Salmonella, thus potentially contaminating food products. Therefore, we aimed to investigate the prevalence of Salmonella in food workers and characterize the isolates by serotyping and antimicrobial susceptibility testing. Salmonella was isolated from 583 (0.079%) of 740,635 stool samples collected from food workers between January and December 2018, and then serotyped into 76 Salmonella enterica serovars and 22 untypeable Salmonella strains. High rates of antimicrobial resistance were observed for streptomycin (51.1%), tetracycline (33.1%), and kanamycin (18.4%). Although isolates were susceptible to ciprofloxacin, 12 (2.1%) strains (one S. Infantis, one S. Manhattan, two S. Bareilly, two S. Blockley, two S. Heidelberg, two S. Minnesota, one S. Goldcoast, and one untypeable Salmonella strain) were resistant to the TGC cefotaxime, all of which harbored β-lactamase genes (blaCMY-2, blaCTX-M-15, blaCTX-M-55, and blaTEM-52B). Moreover, 1.3% (4/309) of Salmonella strains (three S. Infantis and one S. Manhattan strains) isolated from chicken products were resistant to cefotaxime and harbored blaCMY-2 or blaTEM-52B. Thus, food workers may acquire TGC-resistant Salmonella after the ingestion of contaminated chicken products and further contaminate food products.

Antimicrobial resistance profiles of <i>Campylobacter jejuni</i> and <i>Salmonella</i> spp. isolated from enteritis patients in Japan

“…We recently reported that 1.3% (4/309) of Salmonella isolates (three S. Infantis and one S. Manhattan strains) isolated from chicken products sampled between January 2018 and October 2021 were resistant to cefotaxime and harbored blaCMY-2 or blaTEM-52B [31].…”

“…Infantis and one S . Manhattan strains) isolated from chicken products sampled between January 2018 and October 2021 were resistant to cefotaxime and harbored bla CMY-2 or bla TEM-52B [ 31 ]. In the present study, cefotaxime resistance was very low (2.0%, 2/102), and both the TGC-resistant Salmonella isolates were S .…”

“…Schwarzengrund and S . Infantis are the two most prevalent serotypes in chicken meat in Japan, and more than 65% of them are multidrug-resistant [ 22 , 31 , 37 ]. S. Thompson, S .…”

Serotype Distribution and Antimicrobial Resistance Profile of Salmonella Isolated from Traditional Chicken Doner Kebabs in Türkiye

“…isolates they obtained from chicken meat in Romania were resistant to ciprofloxacin and tetracycline, 5 to chloramphenicol, and 2 to ampicillin. Sasaki et al (2021) reported that 100% of the 114 Salmonella spp. isolates they obtained from local and imported chicken meats in Iraq were resistant to ampicillin, 80% to tetracycline, 10% to gentamicin, and 30% to ciprofloxacin.…”

International travel as a risk factor for carriage of extended-spectrum β-lactamase-producing Escherichia coli in a large sample of European individuals - The AWARE Study

“…Antibiotic therapy is also a risk factor for carriage of AR by individuals. Other potential risk factors include travels to high-risk areas for AR , nutrition (28,29), health status (21,25), and occupation (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45). However, most of the studies examining potential risk factors focus on high-risk populations such as travelers (8,10,14,18,20,25,26,46), healthcare workers and patients (39,44,45,47,48), swimmers (49)(50)(51), farmers (32)(33)(34)(35)37,38,40,42,43), and slaughterhouse workers (31), and often using small convenience samples of e.g.…”