Antimicrobial resistance of <i>Staphylococcus aureus</i> isolated from impetigo patients between 1994 and 2000

Nishijim, Setsuko; Ohshima, S.; Higashida, Toshiaki; Nakaya, Hideo; Kurokawa, Ichiro

doi:10.1046/j.1365-4362.2003.01616.x

Cited by 10 publications

(6 citation statements)

References 7 publications

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“…In the present study, the frequency of S. aureus causing skin infection is more than CNS, 65.35% and 34.7%, respectively. This is in line with the previous findings of Nishijim et al (12) and Schmidt et al (13). In total, sixty out of 75 (80%) isolated Staphylococci were biofilm producers.…”

Section: Discussionsupporting

confidence: 94%

Some Virulence Factors of Staphylococci Isolated From Wound and Skin Infections in Shahrekord, IR Iran

Ebrahimi‬¹,

Ghasemi²,

Ghasemi³

2014

Jundishapur J Microbiol

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Background:Staphylococci release a large number of enzymes. Some of these, such as coagulase, beta- lactamase, hemolysins and biofilms are considered indices of pathogenicity.Objectives:The aim of the current study was based on the isolation and identification of Staphylococcus aureus and coagulase negative Staphylococci (CNS) strains from various skin lesions and examining their biofilms, beta- lactamase, hemolysins production and antibiotic resistance pattern.Materials and Methods:Sixty one infected wounds and 39 skin infections samples were collected and examined. After the culture and identification, examination for production of hemolysins, beta- lactamase, biofilm and susceptibility toward 9 antimicrobials was performed.Results:Out of 75 isolated Staphylococci, sixty (80%) were biofilm producers. Two overall prevalence of 28.5% and 100% of ß-lactamase production were recorded for isolated S. aureus and CNS, respectively. Twenty out of 49 (40.8%), the same number of α- and β- hemolytic S. aureus, were isolated while six (12.24%) were ∂ -hemolysin producers. Twenty two of Twenty six (84.6%) isolates of CNS, were hemolysin producers that all were ∂ type. The S. aureus isolates from wound infections, show a high sensitivity pattern to all examined antibiotics, this sensitivity pattern for isolates from skin dermatitis is relatively low, though.Conclusions:High percentage of hemolysins, biofilm and beta lactamase production by isolated Staphylococci, suggests an important role of these virulence factors in the pathogenesis of isolated Staphylococci from dermatitis lesions. The S. aureus isolates from wound infections, show a high sensitivity pattern to all examined antibiotics. Only ciprofloxacin was found to be active against all isolates from dedermatitis lesions.

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Section: Discussionsupporting

confidence: 94%

Some Virulence Factors of Staphylococci Isolated From Wound and Skin Infections in Shahrekord, IR Iran

Ebrahimi‬¹,

Ghasemi²,

Ghasemi³

2014

Jundishapur J Microbiol

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“…Impetigo is a highly contagious infection of the superficial epidermis and is commonly caused by exfoliative toxins (ETs) of S. aureus [ 19 ]. The ratio of MRSA among S. aureus isolates from patients with impetigo between 1994 and 2000 was below 20% in Japan [ 20 ]. However, the ratio of MRSA has recently increased to 20 ~ 50% in Japan [ 21 – 24 ].…”

Section: Introductionmentioning

confidence: 99%

Predominant Dissemination of PVL-Negative CC89 MRSA with SCCmecType II in Children with Impetigo in Japan

Kikuta

Shibata

Nakata³

et al. 2011

International Journal of Pediatrics

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Background. The ratio of CA-MRSA in children with impetigo has been increasing in Japan. Methods. Antimicrobial susceptibilities of 136 S. aureus isolates from children with impetigo were studied. Furthermore, molecular epidemiological analysis and virulence gene analysis were performed. Results. Of the 136 S. aureus isolates, 122 (89.7%) were MSSA and 14 (10.3%) were MRSA. Of the 14 MRSA strains, 11 belonged to CC89 (ST89, ST91, and ST2117) and carried diverse types of SCCmec: type II (IIb: 3 strains; unknown subtype: 4 strains), type IVa (2 strains), and unknown type (2 strains). The remaining three strains exhibited CC8 (ST-8)-SCCmec type VIa, CC121 (ST121)-SCCmec type V, and CC5 (ST5)-nontypeable SCCmec element, respectively. None were lukS-PV-lukF-PV gene positive. Gentamicin- and clarithromycin-resistant strains were frequently found in both MRSA and MSSA. Conclusions. PVL-negative CC89-SCCmec type II strains are the most predominant strains among the CA-MRSA strains circulating in the community in Japan.

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“…Since gentamicin has been used generally in Japan for many years, it is commonly accepted that the use of antibiotics promotes bacterial substitution and leads to the appearance of drug‐resistant bacterial strains (24). It is likely that the frequent use of topical gentamicin has induced the appearance of bacterial strains resistant to gentamicin (24, 25).…”

Section: Discussionmentioning

confidence: 99%

Topical Antibiotic Treatment of Impetigo with Tetracycline

Kuniyuki

Nakano

Maekawa

et al. 2005

The Journal of Dermatology

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Forty-nine children aged 0.2-13 years with bullous and eroded lesions, from which Staphylococcus aureus was isolated, were diagnosed with impetigo and entered into a randomized, open-labeled trial of topical oxytetracycline hydrochloride (tetracycline) compared with a combination of topical tetracycline and oral antibiotics. After one week of topical tetracycline treatment, 22 of the 28 patients were clinically cured, and the remaining six patients had improved. In the other treatment group, 14 patients of 21 were clinically cured and 7 patients improved by the combination of topical tetracycline and oral antibiotics. There were no significant differences between the two groups. Therefore, the present study suggests that topical tetracycline treatment is effective for the treatment of impetigo.

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Antimicrobial resistance of Staphylococcus aureus isolated from impetigo patients between 1994 and 2000

Abstract: Clindamycin has shown excellent activity against most S. aureus isolates between 1994 and 2000. The incidence of methicillin-resistant S. aureus was always below 20%.

Cited by 10 publications

References 7 publications

Some Virulence Factors of Staphylococci Isolated From Wound and Skin Infections in Shahrekord, IR Iran

Some Virulence Factors of Staphylococci Isolated From Wound and Skin Infections in Shahrekord, IR Iran

Predominant Dissemination of PVL-Negative CC89 MRSA with SCCmecType II in Children with Impetigo in Japan

Topical Antibiotic Treatment of Impetigo with Tetracycline

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